Short Inescapable Stress Produces Long-Lasting Changes in the Brain-Pituitary-Adrenal Axis of Adult Male Rats

1993 ◽  
Vol 58 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Hielke H. van Dijken ◽  
Dimphena C.E. de Goeij ◽  
Win Sutanto ◽  
Jan Mos ◽  
Ron de Kloet ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
Adrenal Axis ◽  
The Brain ◽  
Pituitary Adrenal Axis

scholarly journals Effects of Acupuncture, RU-486 on the Hypothalamic-Pituitary-Adrenal Axis in Chronically Stressed Adult Male Rats

Endocrinology ◽  
2015 ◽  
Vol 156 (10) ◽  
pp. 3649-3660 ◽  
Author(s):  
Ladan Eshkevari ◽  
Susan E. Mulroney ◽  
Rupert Egan ◽  
Lixing Lao
Keyword(s):  
Cold Stress ◽  
Adult Male ◽  
Stress Responses ◽  
Male Rats ◽  
Control Group ◽  
Ru 486 ◽  
Adrenal Axis ◽  
Stomach Meridian ◽  
Anxious Behavior ◽  
Pituitary Adrenal Axis

We have recently reported that pretreatment with electroacupuncture (EA) at stomach meridian point 36 (St36) prevents the chronic cold-stress increase in the hypothalamus-pituitary-adrenal axis (HPA), an action that may be under central control. Given that treatment for stress-related symptoms usually begins after onset of the stress responses, the objectives of the present study were to determine the efficacy of EA St36 on HPA hormones when EA St36 is given after stress was initiated, if the results are long lasting, and if blocking the glucocorticoid receptor (GR) using RU-486 had the same effects as EA St36. Adult male rats were placed in 4 groups of animals, 3 of which were exposed to cold and 1 of which was a nontreatment control group. After exposure to the cold stress, 2 groups were treated with either EA St36 or sham-EA, repeated over 10 days. The increase in ACTH and corticosterone observed in stress-only rats was prevented in EA St36 animals, and the effects remained intact 4 days after withdrawal of EA but continuation of cold stress. When the GR was blocked with RU-486, the efficacy of EA St36 remained unchanged. GR blockade did significantly elevate ACTH, which is not seen with EA St36, suggesting that EA St36 does act centrally. The elevated HPA hormones in stress-only rats were associated with a significant increase in depressive and anxious behavior; this was not observed in the stressed EA St36 animals. The results indicate that EA specifically at St36 vs sham-EA is effective in treating chronic poststress exposure.

scholarly journals Strain Difference in Pituitary-adrenal Axis between Wistar-Imamichi and Long Evans Adult Male Rats

2003 ◽  
Vol 52 (5) ◽  
pp. 437-439 ◽  
Author(s):  
Atsushi TOHEI ◽  
Yasuyuki MOGI ◽  
Hiroe KON ◽  
Ryoji HOKAO ◽  
Motoo SHINODA
Keyword(s):  
Adult Male ◽  
Strain Difference ◽  
Male Rats ◽  
Adrenal Axis ◽  
Long Evans ◽  
Pituitary Adrenal Axis

scholarly journals The effects of chronic SRIH-14 and octreotide administration on the pituitary-adrenal axis in adult male rats

10.4081/1187 ◽  
2009 ◽  
Vol 52 (1) ◽  
pp. 61
Author(s):  
S Trifunovic ◽  
B Filipovic ◽  
V Ajdžanovic ◽  
B Å oÅ¡ic-Jurijevic ◽  
M Manojlovic-Stojanoski ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

Altered Control of the Hypothalamo-Pituitary-Adrenal Axis in Adult Male Rats Exposed Perinatally to Food Deprivation and/or Dehydration

2002 ◽  
Vol 76 (4) ◽  
pp. 243-253 ◽  
Author(s):  
Naima Sebaai ◽  
Jean Lesage ◽  
Didier Vieau ◽  
Abdelilah Alaoui ◽  
Jean Paul Dupouy ◽  
...  
Keyword(s):  
Food Deprivation ◽  
Adult Male ◽  
Male Rats ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis
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