Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates Arginine Vasopressin Release in Conscious Rats

1993 ◽  
Vol 57 (6) ◽  
pp. 1092-1096 ◽  
Author(s):  
Takashi Murase ◽  
Kunïkazu Kondo ◽  
Kazuo Otake ◽  
Yutaka Oiso
Keyword(s):  
Adenylate Cyclase ◽  
Arginine Vasopressin ◽  
Vasopressin Release ◽  
Conscious Rats ◽  
Pituitary Adenylate Cyclase

Centrally administered galanin inhibits osmotically stimulated arginine vasopressin release in conscious rats

1991 ◽  
Vol 128 (2) ◽  
pp. 245-248 ◽  
Author(s):  
Kunikazu Kondo ◽  
Takashi Murase ◽  
Kazuo Otake ◽  
Masafumi Ito ◽  
Yutaka Oiso
Keyword(s):  
Arginine Vasopressin ◽  
Vasopressin Release ◽  
Conscious Rats

scholarly journals Role of Endogenous Nociceptin in the Regulation of Arginine Vasopressin Release in Conscious Rats

Endocrinology ◽  
2000 ◽  
Vol 141 (12) ◽  
pp. 4466-4471 ◽  
Author(s):  
Satoshi Kakiya ◽  
Takashi Murase ◽  
Hiroshi Arima ◽  
Hisashi Yokoi ◽  
Yasumasa Iwasaki ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Vasopressin Release ◽  
Conscious Rats

scholarly journals Centrally Administered Tuberoinfundibular Peptide of 39 Residues Inhibits Arginine Vasopressin Release in Conscious Rats

Endocrinology ◽  
2003 ◽  
Vol 144 (7) ◽  
pp. 2791-2796 ◽  
Author(s):  
Yoshihisa Sugimura ◽  
Takashi Murase ◽  
Seiji Ishizaki ◽  
Kazushige Tachikawa ◽  
Hiroshi Arima ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Maximum Effect ◽  
Intracerebroventricular Injection ◽  
Inhibitory Effects ◽  
Endogenous Ligand ◽  
Vasopressin Release ◽  
Conscious Rats ◽  
Tuberoinfundibular Peptide ◽  
The Brain ◽  
Opioid Systems

Abstract Tuberoinfundibular peptide of 39 residues (TIP39) is a recently discovered neuropeptide identified on the basis of its ability to activate the PTH2 receptor, and it is thought to be the brain PTH2 receptor’s endogenous ligand. The PTH2 receptor is highly expressed in the hypothalamus, suggesting a role in the modulation of neuroendocrinological functions. PTHrP, which also belongs to the PTH-related peptides family, stimulates arginine vasopressin (AVP) release. In the present study, therefore, we investigated the effect of centrally administered TIP39 on AVP release in conscious rats. Intracerebroventricular administration of TIP39 (10–500 pmol/rat) significantly suppressed the plasma AVP concentration in dehydrated rats, and the maximum effect was obtained 5 min after administration (dehydration with 100 pmol/rat TIP39, 4.32 ± 1.17 pg/ml; vs. control, 8.21 ± 0.70 pg/ml). The plasma AVP increase in response to either hyperosmolality [ip injection of hypertonic saline (HS), 600 mosmol/kg] or hypovolemia [ip injection of polyethylene glycol (PEG)] was also significantly attenuated by an intracerebroventricular injection of TIP39 (HS with 100 pmol/rat TIP39, 2.65 ± 0.52 pg/ml; vs. HS alone, 4.69 ± 0.80 pg/ml; PEG with 100 pmol/rat TIP39, 4.10 ± 0.79 pg/ml; vs. PEG alone, 6.19 ± 0.34 pg/ml). Treatment with naloxone [1.5 mg/rat, sc injection], a nonselective opioid receptor antagonist, significantly reversed the inhibitory effects of TIP39 on AVP release. These results suggest that central TIP39 plays an inhibitory role in the osmoregulation and baroregulation of AVP release and that intrinsic opioid systems are involved in its mechanism.

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP)-like immunoreactivity in human hypothalamus: co-localization with arginine vasopressin

1994 ◽  
Vol 50 (3) ◽  
pp. 267-275 ◽  
Author(s):  
Kazuhiro Takahashi ◽  
Kazuhito Totsune ◽  
Osamu Murakami ◽  
Fumitoshi Satoh ◽  
Masahiko Sone ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Arginine Vasopressin ◽  
Human Hypothalamus ◽  
Pituitary Adenylate Cyclase

scholarly journals Centrally administered neuropeptide FF inhibits arginine vasopressin release in conscious rats.

Endocrinology ◽  
1996 ◽  
Vol 137 (5) ◽  
pp. 1523-1529 ◽  
Author(s):  
H Arima ◽  
T Murase ◽  
K Kondo ◽  
Y Iwasaki ◽  
Y Oiso
Keyword(s):  
Arginine Vasopressin ◽  
Vasopressin Release ◽  
Conscious Rats ◽  
Neuropeptide Ff

The expression of pituitary adenylate cyclase-activating polypeptide (PACAP) mRNA in rat brain: possible role of endogenous PACAP in vasopressin release

1995 ◽  
Vol 185 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Takashi Murase ◽  
Kunikazu Kondo ◽  
Hiroshi Arima ◽  
Yasumasa Iwasaki ◽  
Masafumi Ito ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Rat Brain ◽  
Vasopressin Release ◽  
Pituitary Adenylate Cyclase

Facilitatory effect of pituitary adenylate cyclase activating polypeptide on micturition in normal, conscious rats

Neuroscience ◽  
1995 ◽  
Vol 66 (4) ◽  
pp. 1009-1014 ◽  
Author(s):  
O. Ishizuka ◽  
P. Alm ◽  
B. Larsson ◽  
A. Mattiasson ◽  
K.-E. Andersson
Keyword(s):  
Adenylate Cyclase ◽  
Facilitatory Effect ◽  
Conscious Rats ◽  
Pituitary Adenylate Cyclase
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