Influence of Dopamine on the Altered Release of Prolactin, Luteinizing Hormone, and Follicle-Stimulating Hormone Induced by Interleukin-2 in vitro

1992 ◽  
Vol 56 (6) ◽  
pp. 871-880 ◽  
Author(s):  
Sharada Karanth ◽  
Umeko Marubayashi ◽  
Samuel M. McCann
Keyword(s):  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Interleukin 2 ◽  
Stimulating Hormone

scholarly journals The ratio of exogenous Luteinizing hormone to Follicle stimulating hormone administered for controlled ovarian stimulation is associated with oocytes’ number and competence

2020 ◽  
Vol 40 (1) ◽  
Author(s):  
Dragos Albu ◽  
Alice Albu
Keyword(s):  
Luteinizing Hormone ◽  
Ovarian Stimulation ◽  
Follicle Stimulating Hormone ◽  
Fertilization Rate ◽  
Controlled Ovarian Stimulation ◽  
Human Menopausal Gonadotropin ◽  
Male Factor ◽  
Entire Study ◽  
Stimulating Hormone

Abstract We performed a retrospective study aiming to study the relationship between the ratio of the exogenous luteinizing hormone to follicle stimulating hormone (LH/FSH) administrated for controlled ovarian stimulation (COS) and the number and competence of the oocytes retrieved for in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Eight hundred sixty-eight consecutive infertile patients (mean age 34.54 ± 4.01 years, mean anti-Müllerian hormone (AMH) 2.94 ± 2.07 ng/ml) treated with long agonist protocol and a mixed gonadotropin protocol (human menopausal gonadotropin in association with recombinant FSH (recFSH)) who performed IVF/ICSI between January 2013 and February 2016, were included. Patients with severe male factor were excluded. LH/FSH was calculated based on total doses of the two gonadotropins. We found, after adjustment for confounders, a positive relationship between LH/FSH and the retrieved oocytes’ (β = 0.229, P<0.0001) and zygotes’ number (β = 0.144, P<0.0001) in the entire study group and in subgroups according to age (<35 and ≥35 years) and ovarian reserve (AMH < 1.1 and ≥ 1.1 ng/ml). The fertilization rate was positively associated with LH/FSH in patients with LH/FSH in the lowest three quartiles (below 0.77) (β = 0.096, P=0.034). However, patients in the fourth quartile of LH/FSH had a lower fertilization rate as compared with patients in quartiles 1–3 which, after adjustment for covariates, was only marginally negatively related with LH/FSH (β = −0.108, P=0.05). In conclusion, our results suggest that the adequate LH/FSH administrated during COS can improve the oocytes’ and zygotes’ number in IVF/ICSI cycles, but also the fertilization rate when a certain proportion of LH/FSH is not exceeded.

Inhibition of release of a novel pituitary polypeptide, 7B2, follicle-stimulating hormone, and luteinizing hormone from rat anterior pituitary cells in vitro by human β-inhibin

1986 ◽  
Vol 64 (9) ◽  
pp. 1259-1262 ◽  
Author(s):  
John S. D. Chan ◽  
Jie-Ying Deng ◽  
Anoop K. Brar ◽  
Nabil G. Seidah ◽  
Michel Chrétien
Keyword(s):  
Luteinizing Hormone ◽  
Anterior Pituitary ◽  
Polyclonal Antibodies ◽  
Follicle Stimulating Hormone ◽  
Feedback Mechanism ◽  
Pituitary Cells ◽  
Anterior Pituitary Cells ◽  
Specific Radioimmunoassay ◽  
Stimulating Hormone

We have recently purified a novel pituitary polypeptide designated 7B2. By raising polyclonal antibodies to a synthetic 7B2 fragment in rabbits, we have developed a sensitive and specific radioimmunoassay for this novel polypeptide, and it has been used for the study of the release of immunoreactive 7B2 from rat anterior pituitary cells in vitro. In addition, immunocytochemical study shows that 7B2 is present in the gonadotropin cells of rat anterior pituitary. The aim of the present studies is to investigate the effect of human β-inhibin, testosterone, and combined testosterone plus human β-inhibin on the induced release of immunoreactive 7B2, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) in rat anterior pituitary cell culture in vitro. Our results show that both human β-inhibin and testosterone effectively suppress the stimulatory effect of luteinizing hormone-releasing hormone (LHRH) on immunoreactive 7B2, FSH, and LH release. The present data indicate that the regulation of secretion of 7B2 and pituitary gonadotropins may be under a similar type of feedback mechanism.

OESTROGEN SYNTHESIS IN RAT OVARIES IN VITRO: EFFECTS OF ENDOGENOUS AND EXOGENOUS GONADOTROPHINS

1972 ◽  
Vol 53 (3) ◽  
pp. 397-406 ◽  
Author(s):  
BRENDA ROBINSON ◽  
R. E. OAKEY
Keyword(s):  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Oestrous Cycle ◽  
The Other ◽  
Ovarian Vein ◽  
Hormone Activity ◽  
In Vitro Effects ◽  
Stimulating Hormone

SUMMARY The rate of synthesis of [14C]oestrone and [14C]oestradiol-17β from [14C]testosterone in vitro by ovaries from rats at different stages of the oestrous cycle was measured. The rate of [14C]oestrogen synthesis was highest in ovaries taken from rats in pro-oestrus and lowest in ovaries taken from rats early in the dioestrous phase of the cycle. Rates of synthesis in ovaries obtained from rats in the late dioestrous stage were intermediate between the rates of the other groups. The rates of [14C]oestrogen synthesis at these periods of the cycle paralleled the concentrations of oestrogens in ovarian vein plasma reported by other authors. Gonadotrophin preparations with either luteinizing hormone activity or both follicle-stimulating hormone and luteinizing hormone activities had no effect on [14C]oestrogen synthesis by rat ovaries in vitro at any of these stages of the oestrous cycle.

Sign in / Sign up

Export Citation Format

Share Document