Strategies for Conditional Two-Locus Nonparametric Linkage Analysis

2008 ◽  
Vol 66 (3) ◽  
pp. 138-156
Author(s):  
Lars Ängquist ◽  
Ola Hössjer ◽  
Leif Groop
Keyword(s):  
Linkage Analysis ◽  
Nonparametric Linkage Analysis

scholarly journals Performance of the nonparametric linkage analysis using GENEHUNTER for a complicated genetic disease

1999 ◽  
Vol 17 (S1) ◽  
pp. S611-S614 ◽  
Author(s):  
Qimei He ◽  
Barabara Berger Nemesure ◽  
Nancy Role Mendell
Keyword(s):  
Linkage Analysis ◽  
Genetic Disease ◽  
Nonparametric Linkage Analysis

Nonparametric Linkage Analysis Between Schizophrenia and Candidate Genes of Dopaminergic and Serotonergic Systems

CNS Spectrums ◽  
2004 ◽  
Vol 9 (4) ◽  
pp. 302-308
Author(s):  
Alda M. Ambrósio ◽  
James L. Kennedy ◽  
Fabio Macciardi ◽  
Isabel Coelho ◽  
Maria J. Soares ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Candidate Genes ◽  
Dopamine Receptor ◽  
Serotonin Receptor ◽  
Major Effect ◽  
Portuguese Population ◽  
Nonparametric Linkage Analysis ◽  
Linkage Score ◽  
Dopamine Receptor Genes

ABSTRACTBackground:Alterations in dopaminergic and serotonergic systems have been implicated in the pathophysiology of schizophrenia for many years. This study was performed to assess the possible involvement of the dopamine receptor genes D2 (DRD2), D3, D4, serotonin receptor genes 1Dα, 1Dβ, and 2A in the etiology of schizophrenia.Methods:We examined 33 multiplex schizophrenic families from Portugal.Results:Linkage analysis performed by GENE-HUNTER showed nonsignificant linkage for these genes. A maximum nonparametric linkage score of 1.635 (P=.032) at DRD2 gene was observed, and this finding suggests DRD2 gene for further studies.Conclusion:the polymorphisms studied at dopamine receptor genes D3, D4, serotonin receptor genes 1Dα, 1Dβ, and 2A do not have a major effect in susceptibility to schizophrenia in a Portuguese population.

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