Sleep-Associated Augmentation and Synchronization of Luteinizing Hormone Pulses in Adult Men

1991 ◽  
Vol 54 (3) ◽  
pp. 192-195 ◽  
Author(s):  
Lorenz Fehm ◽  
Jens Clausing ◽  
Werner Kern ◽  
Reinhard Pietrowsky ◽  
Jan Born
1970 ◽  
Vol 46 (2) ◽  
pp. 229-236 ◽  
Author(s):  
N. SCIARRA ◽  
U. LEONE

SUMMARY The daily urinary excretion of luteinizing hormone (LH) was determined in 15 boys, aged 5–11 yr., and in 15 adult men, aged 18–65 yr., by an immunological method using the haemagglutination inhibition system. The hormone was detected in every subject investigated. The mean value for urinary LH excretion in boys was equivalent to 3·4 i.u./24 hr. (range 1·3–6·5) and was 29·3 i.u./24 hr. in adults (range 15·4–44·6). The mean adult: child ratio was 8·6. There was a significant increase in LH output with age in both the boys and the men; the rate of this increase was the same in both groups. However, there was a sharp rise in hormone output at about the onset of puberty.


1962 ◽  
Vol 39 (4) ◽  
pp. 539-546 ◽  
Author(s):  
Leif Wide ◽  
Carl Gemzell

ABSTRACT An immunological method to assay human pituitary luteinizing hormone (HPLH) in urine is described. It is based on the fact that HPLH crossreacts with human chorionic gonadotrophin (HCG) in an haemagglutination inhibition reaction between HCG-coated blood cells and rabbit HCG-antisera. During the menstrual cycle the excretion of HPLH reached a peak of 200–400 U per liter at the time of ovulation. In the urine of post-menopausal women the concentration of HPLH was between 100 and 400 U per liter. In the urine of adult men the concentration of HPLH was between 50 and 160 U per liter.


1988 ◽  
Vol 67 (4) ◽  
pp. 832-838 ◽  
Author(s):  
DONALD K. CLIFTON ◽  
SEZER AKSEL ◽  
WILLIAM J. BREMNER ◽  
ROBERT A. STEINER ◽  
MICHAEL R. SOULES

1978 ◽  
Vol 47 (2) ◽  
pp. 447-452 ◽  
Author(s):  
ROBERT T. RUBIN ◽  
RUSSELL E. POLAND ◽  
IRVING SOBEL ◽  
BARBARA B. TOWER ◽  
WILLIAM D. ODELL

2004 ◽  
Vol 84 (3-4) ◽  
pp. 279-291 ◽  
Author(s):  
K.E Fike ◽  
F.N Kojima ◽  
B.R Lindsey ◽  
E.G.M Bergfeld ◽  
J.A Quintal-Franco ◽  
...  

1984 ◽  
Vol 107 (3) ◽  
pp. 289-294 ◽  
Author(s):  
Vanna Montanini ◽  
Marco Francesco Celani ◽  
Gian Franco Baraghini ◽  
Cesare Carani ◽  
Paolo Marrama

Abstract. The responses of biologically active LH (BIO-LH) and immunoreactive LH (RIA-LH) to acute stimulation with LRH (0.1 mg iv) were studied in 8 pubertal boys (9–15 years, 2nd–4th Tanner's stage), and in 10 healthy adult men (20–46 years). Serum levels of BIO-LH were assessed by an in vitro bioassay method based upon testosterone production by mechanically dispersed mouse Leydig cell preparations. In pubertal boys the mean BIO-LH/RIA-LH (B/I) ratio of basally secreted LH was significantly lower than in adult men (1.2 ± 0.2 (sem) and 2.2 ± 0.2 respectively, P < 0.01). After acute administration of LRH the mean B/I ratio of circulating LH showed a significant increase from the basal value in pubertal boys (2.6 ± 0.2, P < 0.01 vs basal values), whereas no significant difference in LH B/I ratios were demonstrated throughout the study period in adult men (2.1 ± 0.1, P = NS vs basal values). In agreement with this finding, the mean relative maximum response for BIO-LH (BIO-LH Δ%) was higher in pubertal boys than in adult men (1702.7 ± 500.3 and 499.6 ± 65.4% respectively, P < 0.05), whereas the mean RIA-LH Δ% was similar in both groups (609.1 ± 85.1 and 534.1 ± 75.5% respectively, P = NS). No significant differences were shown in the BIO-LH Δ area between pubertal boys (4.9 ± 0.9 area units × 103) and adult men (6.7 ± 1.2 area units × 103, P = NS), whereas the mean RIA-LH Δ area was significantly lower in the former group (1.9 ± 0.4 area units × 103 vs 3.2 ± 0.5 area units × 103, P < 0.05). Our study emphasizes that the pubertal pituitary possesses a greater responsiveness for BIO-LH than the adult pituitary, and that in pubertal boys acute stimulation with LRH evokes the release of a more bioactive form of LH.


1988 ◽  
Vol 159 (4) ◽  
pp. 898-903 ◽  
Author(s):  
Mary C. Martin ◽  
Scott E. Monroe ◽  
Richard I. Weiner ◽  
Robert B. Jaffe

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