Synergistic Interaction between Opioid Receptor Blockade and Alpha-Adrenergic Stimulation on Luteinizing Hormone-Releasing Hormone (LHRH) Secretion in vitro

1990 ◽  
Vol 51 (2) ◽  
pp. 131-138 ◽  
Author(s):  
Richard W. Clough ◽  
Gloria E. Hoffman ◽  
Celia D. Sladek
Keyword(s):  
Luteinizing Hormone ◽  
Opioid Receptor ◽  
Synergistic Interaction ◽  
Receptor Blockade ◽  
Adrenergic Stimulation ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone

Involvement of H1 Histamine Receptor in Basal and Estrogen-Stimulated Luteinizing Hormone-Releasing Hormone Secretion in Rats in vitro

1987 ◽  
Vol 45 (3) ◽  
pp. 191-196 ◽  
Author(s):  
Akira Miyake ◽  
Shirou Ohtsuka ◽  
Takamichi Nishizaki ◽  
Keiichi Tasaka ◽  
Toshihiro Aono ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Hormone Secretion ◽  
Histamine Receptor ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone

scholarly journals In Vitro Fertilization Using Luteinizing Hormone-Releasing Hormone Injections Resulted in Healthy Triplets without Increased Attack Rates in a Hereditary Angioedema Case

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Ceyda Tunakan Dalgıç ◽  
Fatma Düşünür Günsen ◽  
Gökten Bulut ◽  
Emine Nihal Mete Gökmen ◽  
Aytül Zerrin Sin
Keyword(s):  
Luteinizing Hormone ◽  
Hereditary Angioedema ◽  
Triplet Pregnancy ◽  
C1 Inhibitor Deficiency ◽  
Autosomal Dominant Disorder ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Pregnancy And Delivery ◽  
Prophylactic Use

Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The management of pregnant patients with C1-INH-HAE is a challenge for the physician. Intravenous plasma-derived nanofiltered C1-INH (pdC1INH) is the only recommended option throughout pregnancy, postpartum, and breastfeeding period. In order to increase pregnancy rates, physicians use fertilization therapies increasing endogen levels of estrogens. Therefore, these techniques can provoke an increase in the number and severity of edema attacks in C1-INH-HAE. Our patient is a 32-year-old female, diagnosed with C1-INH-HAE type 1 since 2004. She had been taking danazol 50–200 mg/day for 9 years. Due to her pregnancy plans in 2013, danazol was discontinued. PdC1INH was prescribed regularly for prophylactic purpose. Triplet pregnancy occurred by in vitro fertilization using luteinizing hormone-releasing hormone (LHRH) injections. In our patient, LHRH injections were done four times without causing any severe attack during in vitro fertilization. Angioedema did not worsen during pregnancy and delivery due to the prophylactic use of intravenous pdC1INH in our patient. According to the attack frequency and severity, there was no difference between the three pregnancy trimesters. To our knowledge, this is the first published case of C1-INH-HAE receiving in vitro fertilization therapies without any angioedema attacks during pregnancy and delivery and eventually having healthy triplets with the prophylactic use of intravenous pdC1INH.

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