Involvement of 5-Lipoxygenase Pathway in Norepinephrine Stimulation of Rat Pineal Melatonin Synthesis

1987 ◽  
Vol 46 (5) ◽  
pp. 412-416 ◽  
Author(s):  
Maria I. Vacas ◽  
Maria I. Keller-Sarmiento ◽  
Graciela S. Etchegoyen ◽  
Elba N. Pereyra ◽  
Martha F. Gimeno ◽  
...  
Keyword(s):  
Lipoxygenase Pathway ◽  
Pineal Melatonin ◽  
Melatonin Synthesis ◽  
Stimulation Of

Monosodium glutamate administration early in life alters pineal melatonin nocturnal profile in adulthood

2021 ◽  
Vol 4 (1) ◽  
pp. 99-114
Author(s):  
Janaína B Garcia ◽  
Fernanda G Do Amaral ◽  
Daniela C Buonfiglio ◽  
Rafaela FA Vendrame ◽  
Patrícia L Alves ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Pineal Gland ◽  
Serum Insulin ◽  
Monosodium Glutamate ◽  
Female Rats ◽  
Pineal Melatonin ◽  
Melatonin Synthesis ◽  
Male And Female Rats ◽  
Melatonin Production

The pineal gland synthesizes melatonin exclusively at night, which gives melatonin the characteristic of a temporal synchronizer of the physiological systems. Melatonin is a regulator of insulin activities centrally and also peripherally and its synthesis is reduced in diabetes.  Since monosodium glutamate (MSG) is often used to induce the type 2 diabetic and metabolic syndrome in animal models, the purpose of this work is to evaluate the potential effects of MSG given to neonates on the pineal melatonin synthesis in different aged male and female rats. Wistar rats were subcutaneously injected with MSG (4mg/g/day) or saline solution (0.9%) from the second to eighth post-natal day. The circadian profiles both melatonin levels and AANAT activity were monitored at different ages. Body weight, naso-anal length, adipose tissues weight, GTT, ITT and serum insulin levels were also evaluated. Typical obesity with the neonatal MSG treatment was observed, indicated by a great increase in adipose depots without a concurrent increase in body weight. MSG treatment did not cause hyperglycemia or glucose intolerance, but induced insulin resistance. An increase of melatonin synthesis at ZT 15 with phase advance was observed in in some animals. The AANAT activity was positively parallel to the melatonin circadian profile. It seems that MSG causes hypothalamic obesity which may increase AANAT activity and melatonin production in pineal gland. These effects were not temporally correlated with insulin resistance and hyperinsulinemia indicating the hypothalamic lesions, particularly in arcuate nucleus induced by MSG in early age, as the principal cause of the increase in melatonin production.

Effect of cocaine on rat pineal melatonin synthesis in vivo and in vitro

1990 ◽  
Vol 34 (2) ◽  
pp. 185-191 ◽  
Author(s):  
Gregory F. Oxenkrug ◽  
Ljubisa J. Dragovic ◽  
Bernard H. Marks ◽  
Arthur Yuwiler
Keyword(s):  
Pineal Melatonin ◽  
Melatonin Synthesis

Electric field exposure alters serum melatonin but not pineal melatonin synthesis in male rats

1994 ◽  
Vol 15 (5) ◽  
pp. 427-437 ◽  
Author(s):  
L. J. Grota ◽  
R. J. Reiter ◽  
P. Keng ◽  
S. Michaelson
Keyword(s):  
Electric Field ◽  
Male Rats ◽  
Field Exposure ◽  
Pineal Melatonin ◽  
Melatonin Synthesis

scholarly journals One millisecond of light suffices to suppress nighttime pineal melatonin synthesis in rats

1989 ◽  
Vol 98 (3) ◽  
pp. 297-298 ◽  
Author(s):  
L. Vollrath ◽  
A. Seidel ◽  
A. Huesgen ◽  
B. Manz ◽  
K. Pollow ◽  
...  
Keyword(s):  
Pineal Melatonin ◽  
Melatonin Synthesis
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