Progestin Receptors with and without Estrogen Induction in Male and Female Hamster Brain

1987 ◽  
Vol 45 (6) ◽  
pp. 487-491 ◽  
Author(s):  
Isabel G. Fraile ◽  
Donald W. Pfaff ◽  
Bruce S. McEwen
Keyword(s):  
Male And Female ◽  
Female Hamster ◽  
Progestin Receptors ◽  
Estrogen Induction

scholarly journals Effect of Thymectomy on the Golden Hamster (Mesocricetus Auratus)

Blood ◽  
1964 ◽  
Vol 23 (3) ◽  
pp. 375-388 ◽  
Author(s):  
JOSEPH D. SHERMAN ◽  
MARVIN M. ADNER ◽  
WILLIAM DAMESHEK
Keyword(s):  
Immune Response ◽  
Antibody Production ◽  
Golden Hamster ◽  
Immune Mechanism ◽  
Wasting Disease ◽  
Male And Female ◽  
Female Hamster ◽  
Humoral Antibody ◽  
Impaired Ability ◽  
Impaired Immune Response

Abstract Thymectomy in our hamster colony produced two major changes: (1) wasting disease, and (2) impaired immune response. Wasting occurred in 36 per cent of all males of all ages and was noted even when thymectomy was performed at 4 weeks of age. Lymphoid atrophy was profound and lymphocytopenia sustained. In the non-wasted hamster, the lymphoid atrophy was less striking and there was only transient lymphocytopenia. Experiments in this study were limited to the non-wasted animals. An impaired immune response was demonstrated in both humoral antibody production and in delayed hypersensitivity (heterograft rejection). Male and female hamsters thymectomized at 2 weeks showed an impaired ability to make antibodies against HGG and exhibited prolonged survival of mouse (AJAX) skin. In animals thymectomized at 4 to 8 weeks of age, impaired humoral antibody production could not be demonstrated. Antigen administered on the day of thymectomy was not associated with impaired humoral antibody production. Splenectomy appeared to be more effective than thymectomy in the adult (8-week) hamster in inhibiting humoral antibody production. From these studies, it is evident that the thymectomized, non-wasted male and female hamster has an impaired immune mechanism for both humoral antibody production and heterologous skin rejection.

Chronic administration of melatonin induces changes in porphyrins and in the histology of male and female hamster Harderian gland: Interrelation with the gonadal status

1991 ◽  
Vol 11 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Maria J. Rodriguez-Colunga ◽  
Covadonga Fernandez ◽  
Isaac Antolin ◽  
Carmen Rodriguez ◽  
Delio Tolivia ◽  
...  
Keyword(s):  
Chronic Administration ◽  
Harderian Gland ◽  
Male And Female ◽  
Female Hamster ◽  
Gonadal Status

scholarly journals Estrogen and Progestin Receptors in the Reproductive Tract of Male and Female Primates1

1990 ◽  
Vol 42 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Robert M. Brenner ◽  
Neal B. West ◽  
Maryanne C. McClellan
Keyword(s):  
Reproductive Tract ◽  
Male And Female ◽  
Progestin Receptors

scholarly journals Characterization of rat hypothalamic progestin binding by spheroidal hydroxylapatite chromatography

1980 ◽  
Vol 186 (1) ◽  
pp. 295-300 ◽  
Author(s):  
S Thrower ◽  
L Lim
Keyword(s):  
Female Rats ◽  
Affinity Binding ◽  
Male And Female ◽  
High Affinity Binding ◽  
Progestin Receptors ◽  
High Affinity ◽  
Progestin Receptor ◽  
Male And Female Rats

The progestin-high-affinity-binding components in rat target tissues have been assayed by a simple and precise procedure by using spheroidal hydroxylapatite. The progestin ‘receptors’ in the uterus and hypothalamus of female rats are highly specific for progestins, which they bind with high affinity (Kd for [3H]progesterone in hypothalamus is 1.9 nM and in uterus is 3.7 nM). The dissociation of [3H]progesterone from receptor in vitro is rapid: t1/2 6 degrees C = 45 min in uterine cytosol; t1/2 6 degrees C = 160 min in hypothalamic cytosol. The binding is destroyed by proteinase. In the cytosol of hypothalamus and cortex of developing rats, progestin ‘receptors’ were present in both male and female rats by 2-3 days after birth; subsequent changes in concentration of these ‘receptors’ appeared to be independent of sex. Concentrations of progestin ‘receptor’ were close to adult values by 8-9 days, and thereafter changed relatively little.

Estrogen Induction of Progestin Receptors in Microdissected Hypothalamic and Limbic Nuclei of Female Guinea Pigs

1986 ◽  
Vol 43 (2) ◽  
pp. 182-188 ◽  
Author(s):  
Janice E. Thornton ◽  
Bruce Nock ◽  
Bruce S. McEwen ◽  
Harvey H. Feder
Keyword(s):  
Guinea Pigs ◽  
Progestin Receptors ◽  
Estrogen Induction
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