Role of Sexual Differentiation of the Hypothalamus in the Differential Effect of the Serotoninergic System on LH in Prepubertal Male and Female Rats

1987 ◽  
Vol 45 (4) ◽  
pp. 274-277 ◽  
Author(s):  
Jaime A. Moguilevsky ◽  
Maria R. Faigón ◽  
Pablo Scacchi ◽  
Berta Szwarcfarb
Keyword(s):  
Sexual Differentiation ◽  
Differential Effect ◽  
Female Rats ◽  
Serotoninergic System ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Role of the oxytocin system in amygdala subregions in the regulation of social interest in male and female rats

Neuroscience ◽  
2016 ◽  
Vol 330 ◽  
pp. 138-149 ◽  
Author(s):  
Kelly M. Dumais ◽  
Andrea G. Alonso ◽  
Remco Bredewold ◽  
Alexa H. Veenema
Keyword(s):  
Social Interest ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals 5-HT1 and 5-HT2 receptor activation reduces N-methyl-D-aspartate (NMDA)-stimulated LH secretion in prepubertal male and female rats

2003 ◽  
pp. 121-127 ◽  
Author(s):  
L Pinilla ◽  
LC Gonzalez ◽  
M Tena-Sempere ◽  
E Aguilar
Keyword(s):  
Methyl Ester ◽  
Receptor Activation ◽  
Female Rats ◽  
Receptor Subtypes ◽  
Serotoninergic System ◽  
Gonadotropin Secretion ◽  
Male And Female ◽  
Receptor Agonists ◽  
Male And Female Rats ◽  
Lh Secretion

OBJECTIVE: Excitatory amino acids and serotonin are involved in the control of gonadotropin secretion. The actions of these neurotransmitters are interconnected and recently we have reported that 5-HT(1) and 5-HT(2) receptor agonists blunted (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-stimulated GH secretion in prepubertal rats. The present experiments were carried out to analyze the effects of activation of different 5-hydroxytryptamine (5-HT) receptor subtypes on gonadotropin secretion and their role in the N-methyl-d-aspartate (NMDA)-stimulated LH release. DESIGN AND METHODS: We analyzed the gonadotropin secretion after manipulation of serotoninergic and aminoacidergic systems and their interactions in 5-, 16- and 23-day-old male and female rats. To this end, serum LH and FSH concentrations were measured in rats treated with 5-hydroxytryptophan methyl ester (5-HTP) (a precursor of 5-HT synthesis) plus Fluoxetine (Fx, a blocker of 5-HT reuptake), d,l-p-chlorophenyl-alanine methyl ester (PCPA, a blocker of 5-HT synthesis), R-(+)-8-hydroxydipropylaminotetralin hydrobromide (8-OH-DPAT, an agonist of 5-HT(1A) receptors), (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) and alpha-methyl-5-hydroxytryptamine (alpha-Me-5-HT, agonists of 5-HT(2) receptors), and 1-Phenylbiguanide (1-PHE an agonist of 5-HT(3) receptors). In addition, the effects of 8-OH-DPAT and DOI on NMDA-stimulated LH secretion were analyzed. RESULTS: Neither the activation nor blockade of the serotoninergic system modified LH secretion. Basal gonadotropin secretion remained unchanged in 23-day-old male and female rats after activation of 5-HT(1A), 5-HT(2) and 5-HT(3) receptors. The stimulatory effect of NMDA on LH secretion was blocked in both sexes after activation of the serotoninergic system, through specific 5-HT(1) and 5-HT(2) receptor agonists. CONCLUSIONS: Activation of serotoninergic receptors decreased the stimulatory effect of NMDA on LH secretion in prepubertal male and female rats.

scholarly journals Age-dependent changes in cocaine sensitivity across early ontogeny in male and female rats: possible role of dorsal striatal D2High receptors

2015 ◽  
Vol 232 (13) ◽  
pp. 2287-2301 ◽  
Author(s):  
Sanders A. McDougall ◽  
Shannon E. Eaton ◽  
Alena Mohd-Yusof ◽  
Cynthia A. Crawford
Keyword(s):  
Early Ontogeny ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Age Dependent

scholarly journals Corticosteroid-binding globulin in experimental hypothyroidism in male and female rats

2000 ◽  
Vol 46 (5) ◽  
pp. 35-39
Author(s):  
L. I. Nadolnik ◽  
N. V. Emelyanov ◽  
I. P. Pasteur ◽  
V. V. Vinogradov
Keyword(s):  
Biological Activity ◽  
Thyroid Hormones ◽  
Binding Sites ◽  
Young Male ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Corticosteroid Binding Globulin ◽  
Daily Dose

Main parameters of complex formation of corticosteroid-binding globulin (CSG) were studied in young male and female rats with hypothyrosis induced by mercasolyl in a daily dose of 6 and 30 mg/kg. No pronounced differences in CSG, typical of adult animals, were observed in young rats under conditions of thyroid function inhibition. Steroidand androgen-inhibitory and estrogen-inducing effects of hormones towards CSG did not manifest in hypothyrosis. Decrease in the level of thyroid hormones is characterized by increased affinity of CSG for glucocorticoids and a decrease in the concentration of binding sites. These data indicate that thyroid hormones are the primary regulators of CSG activity. Possibility of modifying CSG affinity and role of this factor in regulation of biological activity of glucocorticoids are discussed.

Cholestasis-associated reproductive toxicity in male and female rats: The fundamental role of mitochondrial impairment and oxidative stress

2019 ◽  
Vol 316 ◽  
pp. 60-72 ◽  
Author(s):  
Mohammad Mehdi Ommati ◽  
Omid Farshad ◽  
Hossein Niknahad ◽  
Mohammad Reza Arabnezhad ◽  
Negar Azarpira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reproductive Toxicity ◽  
Female Rats ◽  
Male And Female ◽  
Mitochondrial Impairment ◽  
Male And Female Rats ◽  
And Oxidative Stress
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