Pre- and Postnatal Influence of an Estrogen Antagonist and an Androgen Antagonist on Differentiation of the Sexually Dimorphic Nucleus of the Preoptic Area in Male and Female Rats

1986 ◽  
Vol 42 (5) ◽  
pp. 443-448 ◽  
Author(s):  
Klaus D. Döhler ◽  
Art Coquelin ◽  
Fred Davis ◽  
Melissa Hines ◽  
James E. Shryne ◽  
...  
Keyword(s):  
Preoptic Area ◽  
Female Rats ◽  
Sexually Dimorphic ◽  
Male And Female ◽  
Male And Female Rats ◽  
Estrogen Antagonist ◽  
Sexually Dimorphic Nucleus

Perinatal Androgenization Prevents Age-Related Neuron Loss in the Sexually Dimorphic Nucleus of the Preoptic Area in Female Rats

2004 ◽  
Vol 26 (1) ◽  
pp. 54-60 ◽  
Author(s):  
Shaw-Lang Yang ◽  
Yu-Yang Chen ◽  
Ya-Lun Hsieh ◽  
Su-Hwa Jin ◽  
Hseng-Kuang Hsu ◽  
...  
Keyword(s):  
Preoptic Area ◽  
Female Rats ◽  
Sexually Dimorphic ◽  
Neuron Loss ◽  
Age Related ◽  
Sexually Dimorphic Nucleus

scholarly journals Blockage of the Neonatal Leptin Surge Affects the Gene Expression of Growth Factors, Glial Proteins, and Neuropeptides Involved in the Control of Metabolism and Reproduction in Peripubertal Male and Female Rats

Endocrinology ◽  
2015 ◽  
Vol 156 (7) ◽  
pp. 2571-2581 ◽  
Author(s):  
Virginia Mela ◽  
Francisca Díaz ◽  
Ana Belen Lopez-Rodriguez ◽  
María Jesús Vázquez ◽  
Arieh Gertler ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Pubertal Development ◽  
Trophic Factors ◽  
Female Rats ◽  
Sexually Dimorphic ◽  
Mrna Levels ◽  
Long Term Effects ◽  
Male And Female ◽  
Male And Female Rats ◽  
Subcutaneous Adipose

Leptin (Lep) is important in the development of neuroendocrine circuits involved in metabolic control. Because both Lep and metabolism influence pubertal development, we hypothesized that early changes in Lep signaling could also modulate hypothalamic (HT) systems involved in reproduction. We previously demonstrated that a single injection of a Lep antagonist (Antag) on postnatal day (PND)9, coincident with the neonatal Lep peak, induced sexually dimorphic modifications in trophic factors and markers of cell turnover and neuronal maturation in the HT on PND13. Here, our aim was to investigate whether the alterations induced by Lep antagonism persist into puberty. Accordingly, male and female rats were treated with a pegylated super Lep Antag from PND5 to PND9 and killed just before the normal appearance of external signs of puberty (PND33 in females and PND43 in males). There was no effect on body weight, but in males food intake increased, subcutaneous adipose tissue decreased and HT neuropeptide Y and Agouti-related peptide mRNA levels were reduced, with no effect in females. In both sexes, the Antag increased HT mRNA levels of the kisspeptin receptor, G protein-coupled recepter 54 (Gpr54). Expression of the Lep receptor, trophic factors, and glial markers were differently affected in the HT of peripubertal males and females. Lep production in adipose tissue was decreased in Antag-treated rats of both sexes, with production of other cytokines being differentially regulated between sexes. In conclusion, in addition to the long-term effects on metabolism, changes in neonatal Lep levels modifies factors involved in reproduction that could possibly affect sexual maturation.

γ-Aminobutyric acid regulation of neurohypophysial hormone secretion in male and female rats

1989 ◽  
Vol 121 (2) ◽  
pp. 343-349 ◽  
Author(s):  
E. Saridaki ◽  
D. A. Carter ◽  
S. L. Lightman
Keyword(s):  
Hormone Secretion ◽  
Model Systems ◽  
Female Rats ◽  
Aminobutyric Acid ◽  
Male Rats ◽  
Sexually Dimorphic ◽  
Male And Female ◽  
Endogenous Gaba ◽  
Male And Female Rats

ABSTRACT The role of γ-aminobutyric acid (GABA) in the control of oxytocin and arginine vasopressin (AVP) release from the posterior pituitary was investigated using the GABA agonist muscimol and the GABA antagonists bicuculline and picrotoxin. Two perifusion model systems were studied using (a) intact isolated posterior pituitaries (IPP) and (b) neurosecretosomes from both male and female rats. In experiments on tissue from male rats, the stimulated release of oxytocin and AVP in both models was inhibited by muscimol, an effect which was reversed in the presence of bicuculline. Bicuculline alone increased the release of oxytocin only. Although similar responses to muscimol or bicuculline were seen in neurosecretosomes from female animals, neither agent affected oxytocin and AVP release from the intact IPP. Picrotoxin had a similar effect to bicuculline on oxytocin in isolated posterior pituitaries from male as well as female rats, although at the neurosecretosome level a paradoxical inhibition was observed. These results provide evidence for an endogenous GABA receptor mechanism at the level of the neurosecretory terminals in both male and female rats. The sexually dimorphic IPP response suggests a second more complex mechanism involving either pituicytenerve terminal interactions and/or a secondary role of other neurotransmitters in the GABA regulation of neurohypophysial hormones. Journal of Endocrinology (1989) 121, 343–349

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