Characterization of Receptors for Angiotensin-Induced Drinking and Blood Pressure Responses in Conscious Rats using Angiotensin Analogs Extended at the N-Terminal

1986 ◽  
Vol 42 (4) ◽  
pp. 289-295 ◽  
Author(s):  
Hiroshi Kawabe ◽  
Ahsan Husain ◽  
Mahesh C. Khosla ◽  
Robert R. Smeby ◽  
F. Merlin Bumpus ◽  
...  
1996 ◽  
Vol 59 (6) ◽  
pp. 1137-1145 ◽  
Author(s):  
H. Liu ◽  
M.L. Terrell ◽  
J.Y. Summy-Long ◽  
M. Kadekaro

1993 ◽  
Vol 74 (5) ◽  
pp. 2086-2091
Author(s):  
K. J. Slavik ◽  
J. LaPointe

The purpose of this investigation was to examine the underlying cause for the resting bradycardia and lower resting blood pressure demonstrated in conscious rats that performed 12 wk of treadmill exercise conditioning. The influence of inhibitory dopamine (DA2) receptors and alpha 2-adrenoceptors, which are known to mediate bradycardia and hypotension, was assessed in exercise-conditioned (EC) and nonexercised conditioned (NC) rats. To accomplish this, preferential DA2 and alpha 2-agonists and antagonists were administered at rest to conscious rats after they participated in an exercise conditioning program. The results obtained with the DA2 antagonist metoclopramide (15 mg/kg ip) alone suggest that there is physiological activation of cardiovascular DA2 receptors in EC rats but not in NC rats. Furthermore, the results obtained with the DA2 agonist bromocriptine (1.5 mg/kg ip) suggest that the DA2 receptor-mediated bradycardia and hypotension are greater in EC rats than in NC rats. In addition, heart rate and blood pressure responses to the alpha 2-agonist clonidine (0.1 mg/kg ip) and antagonist yohimbine (1 mg/kg ip) were not different between EC and NC rats. These data suggest that enhanced DA2 receptor influence accounts, in part, for the resting bradycardia and lower resting blood pressure demonstrated in EC rats after 12 wk of exercise conditioning.


1990 ◽  
Vol 162 (3) ◽  
pp. 203-212 ◽  
Author(s):  
MINORU YASUJIMA ◽  
KEISHI ABE ◽  
MASAYA TANNO ◽  
MASAHIRO KOHZUKI ◽  
MASAYUKI KANAZAWA ◽  
...  

2009 ◽  
Vol 23 (2) ◽  
pp. 77-84 ◽  
Author(s):  
Matthew C. Whited ◽  
Kevin T. Larkin

Sex differences in cardiovascular reactivity to stress are well documented, with some studies showing women having greater heart rate responses than men, and men having greater blood pressure responses than women, while other studies show conflicting evidence. Few studies have attended to the gender relevance of tasks employed in these studies. This study investigated cardiovascular reactivity to two interpersonal stressors consistent with different gender roles to determine whether response differences exist between men and women. A total of 26 men and 31 women were assigned to either a traditional male-oriented task that involved interpersonal conflict (Conflict Task) or a traditional female-oriented task that involved comforting another person (Comfort Task). Results demonstrated that women exhibited greater heart rate reactions than men independent of the task type, and that men did not display a higher reactivity than women on any measure. These findings indicate that sex of participant was more important than gender relevance of the task in eliciting sex differences in cardiovascular responding.


1996 ◽  
Author(s):  
James A. McCubbin ◽  
John F. Wilson ◽  
Jeffrey J. Sherman ◽  
Jane A. Norton ◽  
George Colclough

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