The Role of Pheromones in the Regulation of Estrous Cycle Duration in the Guinea Pig

1976 ◽  
Vol 20 (2) ◽  
pp. 97-109 ◽  
Author(s):  
L. Jesel ◽  
Cl. Aron
Keyword(s):  
Guinea Pig ◽  
Estrous Cycle ◽  
Cycle Duration

scholarly journals Role of chloride channels in bradykinin-induced guinea pig airway vagal C-fibre activation

2005 ◽  
Vol 566 (1) ◽  
pp. 205-212 ◽  
Author(s):  
Min-Goo Lee ◽  
Donald W. MacGlashan ◽  
Bradley J. Undem
Keyword(s):  
Guinea Pig ◽  
Chloride Channels ◽  
C Fibre

scholarly journals Role of endothelial cell hyperpolarization in EDHF-mediated responses in the guinea-pig carotid artery

2000 ◽  
Vol 129 (6) ◽  
pp. 1103-1112 ◽  
Author(s):  
J -F Quignard ◽  
M Félétou ◽  
G Edwards ◽  
J Duhault ◽  
A H Weston ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Carotid Artery ◽  
Guinea Pig

Role of hepatic γ-glutamyltransferase in the degradation of circulating glutathione: Studies in the intact guinea pig perfused liver

Hepatology ◽  
1990 ◽  
Vol 11 (5) ◽  
pp. 843-849 ◽  
Author(s):  
Hernan Speisky ◽  
Nick Shackel ◽  
George Varghese ◽  
Denis Wade ◽  
Yedy Israel
Keyword(s):  
Guinea Pig ◽  
Perfused Liver

The role of prostaglandins in cholinergic neurotransmission in the guinea pig

1975 ◽  
Vol 34 (1) ◽  
pp. 39-47 ◽  
Author(s):  
William J. Hall ◽  
Padraic O'Neill ◽  
John D. Sheehan
Keyword(s):  
Guinea Pig ◽  
Cholinergic Neurotransmission

scholarly journals Key Role of Capsular Polysaccharide in the Induction of Systemic Infection and Abortion by Hypervirulent Campylobacter jejuni

2017 ◽  
Vol 85 (6) ◽  
Author(s):  
Orhan Sahin ◽  
Samantha A. Terhorst ◽  
Eric R. Burrough ◽  
Zhangqi Shen ◽  
Zuowei Wu ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Campylobacter Jejuni ◽  
Capsular Polysaccharide ◽  
Systemic Infection ◽  
The United States ◽  
Content Type ◽  
Model Following ◽  
Capsule Production ◽  
Guinea Pig Model

ABSTRACT Campylobacter jejuni is a zoonotic pathogen, and a hypervirulent clone, named clone SA, has recently emerged as the predominant cause of ovine abortion in the United States. To induce abortion, orally ingested Campylobacter must translocate across the intestinal epithelium, spread systemically in the circulation, and reach the fetoplacental tissue. Bacterial factors involved in these steps are not well understood. C. jejuni is known to produce capsular polysaccharide (CPS), but the specific role that CPS plays in systemic infection and particularly abortion in animals remains to be determined. In this study, we evaluated the role of CPS in bacteremia using a mouse model and in abortion using a pregnant guinea pig model following oral challenge. Compared with C. jejuni NCTC 11168 and 81-176, a clone SA isolate (IA3902) resulted in significantly higher bacterial counts and a significantly longer duration of bacteremia in mice. The loss of capsule production via gene-specific mutagenesis in IA3902 led to the complete abolishment of bacteremia in mice and abortion in pregnant guinea pigs, while complementation of capsule expression almost fully restored these phenotypes. The capsule mutant strain was also impaired for survival in guinea pig sera and sheep blood. Sequence-based analyses revealed that clone SA possesses a unique CPS locus with a mosaic structure, which has been stably maintained in all clone SA isolates derived from various hosts and times. These findings establish CPS as a key virulence factor for the induction of systemic infection and abortion in pregnant animals and provide a viable candidate for the development of vaccines against hypervirulent C. jejuni.

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