Distribution and Changes in Strength of Hand Preference of Cynomolgus Monkeys

1980 ◽  
Vol 17 (3) ◽  
pp. 209-217 ◽  
Author(s):  
Ralph A.W. Lehman
Keyword(s):  
Hand Preference ◽  
Cynomolgus Monkeys

Hexachlorobenzene toxicity in the monkey ovary: III. Ultrastructure induced by high (10 mg/kg) dose exposure

1991 ◽  
Vol 49 ◽  
pp. 130-131
Author(s):  
A. Singh ◽  
A. Dykeman ◽  
J. Jarrelf ◽  
D. C. Villeneuve
Keyword(s):  
Present Report ◽  
Reproductive Toxicity ◽  
Control Group ◽  
Primate Model ◽  
Human Follicular Fluid ◽  
Thin Sections ◽  
Cynomolgus Monkeys ◽  
Cacodylate Buffer ◽  
Induction Cycle ◽  
Comprehensive Study

Hexachlorobenzene (HCB), a persistent and mobile organochlorine pesticide, occurs in environment. HCB has been shown to be present in human follicular fluid. An objective of the present report, which is part of a comprehensive study on reproductive toxicity of HCB, was to determine the cytologic effects of the compound on ovarian follicles in a primate model.Materials and Methods. Eight Cynomolgus monkeys were housed under controlled conditions at Animal facility of Health and Welfare, Ottawa. Animals were orally administered gelatin capsules containing HCB mixed with glucose in daily dosages of 0.0 or 10 mg/kg b.w. for 90 days; the former was the control group. On the menstrual period following completion of dosing, the monkeys underwent an induction cycle of superovulation. At necropsy, one-half of an ovary from each animal was diced into ca. 2- to 3-mm cubed specimens that were fixed by immersion in 2.5% glutaraldehyde in 0.1 M cacodylate buffer (pH 7.3). Subsequent procedures followed to obtain thin sections that were examined in a Hitachi H-7000 electron microscope have been described earlier.

Hemodynamic effects of induced fetal anemia in cynomolgus monkeys

1998 ◽  
Vol 5 (1) ◽  
pp. 159A-159A
Author(s):  
W BLOCK ◽  
M OSULLIVAN ◽  
N SMITH ◽  
M DRAPER ◽  
C MIRABILE ◽  
...  
Keyword(s):  
Fetal Anemia ◽  
Hemodynamic Effects ◽  
Cynomolgus Monkeys

Effectiveness of zona pellucida protein ZPB as an immunocontraceptive antigen

Reproduction ◽  
2000 ◽  
pp. 19-32 ◽  
Author(s):  
ML Martinez ◽  
JD Harris
Keyword(s):  
Menstrual Cycle ◽  
Recombinant Protein ◽  
Antibody Titre ◽  
Zona Pellucida ◽  
Protein A ◽  
Papio Cynocephalus ◽  
Cynomolgus Monkeys ◽  
Menstrual Cycles ◽  
Normal Menstrual Cycle

Immunization of female mammals with native zona pellucida (ZP) proteins is known to cause infertility. Since each human ZP protein is now available as a purified recombinant protein, is it possible to compare the immunocontraceptive potential of each ZP protein. A breeding study was conducted in cynomolgus monkeys (Macaca fasicularis) after immunization with recombinant human ZP (rhZP) proteins (ZPA, ZPB, ZPC) separately and in combinations. This study demonstrated that immunization with recombinant human ZPB (rhZPB) protein caused cynomolgus monkeys to become infertile for 9-35 months. A second study was conducted in baboons (Papio cynocephalus), which yielded a similar result. The baboons immunized with rhZPB became infertile for 9 to > 20 months. During the time of maximum antibody titre, some animals experienced disruption of the menstrual cycle, but eventually all of the animals resumed normal menstrual cycles. Control animals and animals immunized with other rhZP proteins all became pregnant before any of the rhZPB-treated animals. This is the first study in which a recombinant ZP protein has consistently induced infertility in a primate without permanent disruption of the normal menstrual cycle.

Generation of GFP transgenic cynomolgus monkeys

2016 ◽  
Author(s):  
Yasunari Seita ◽  
Tomonori Tsukiyama ◽  
Chizuru Iwatani ◽  
Hideaki Tsuchiya ◽  
Jun Matsushita ◽  
...  
Keyword(s):  
Cynomolgus Monkeys

Changes of lymphocyte subset in pregnant cynomolgus monkeys

1995 ◽  
Vol 11 (3) ◽  
pp. 169-178
Author(s):  
Takeyuki NAGASHIMA ◽  
Akihiro KUBO ◽  
Yuichi MURAYAMA ◽  
Atsuo NOGUCHI ◽  
Keiji TERAO
Keyword(s):  
Lymphocyte Subset ◽  
Cynomolgus Monkeys
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