scholarly journals Blood Levels of Brain-Derived Neurotrophic Factor Correlate with Several Psychopathological Symptoms in Anorexia Nervosa Patients

2007 ◽  
Vol 56 (4) ◽  
pp. 185-190 ◽  
Author(s):  
Josep M. Mercader ◽  
Fernando Fernández-Aranda ◽  
Mònica Gratacòs ◽  
Marta Ribasés ◽  
Anna Badía ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Blood Levels ◽  
Psychopathological Symptoms

Circulating Brain-Derived Neurotrophic Factor as a potential biomarker in stroke: a Systematic review and Meta-analysis

2021 ◽  
Author(s):  
Helia Mojtabavi ◽  
Zoha Shaka ◽  
Sara Momtazmanesh ◽  
Atra Ajdari ◽  
Nima Rezaei
Keyword(s):  
Physical Training ◽  
Neurotrophic Factor ◽  
Neuronal Damage ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Blood Levels ◽  
Cerebrovascular Event ◽  
Medical Databases ◽  
Potential Biomarker ◽  
Significant Difference

Abstract Background Stroke, an acute cerebrovascular event, is a leading cause of disability, placing a significant psycho-socioeconomic burden worldwide. Neuroplasticity is adaptation and reorganization following neuronal damage. Brain-derived neurotrophic factor (BDNF) is a neurotrophin coordinating neuroplasticity after various neurological disorders such as stroke. Methods We conducted a systematic search in the main electronic medical databases through January 2021 and identified studies that measured blood levels of BDNF in patients with stroke. The primary aim was to compare BDNF levels between patients with stroke and healthy controls (HC). The secondary aims included investigation of (1) longitudinal changes in the BDNF levels post-stroke, (2) effects of physical training, (3) repeated transcranial magnetic stimulation (rTMS), and presence of depression on BDNF levels in patients with stroke. Results Among 6243 reviewed records from PubMed, Web of Science, and Scopus, 62 studies were eligible for inclusion. Subjects with stroke, n = 1856, showed lower BDNF levels compared to HC, n=1191 (SMD [95%CI] = -1.04 [-1.49 to -0.58]). No significant difference was detected in the level of BDNF through time points past stroke. BDNF levels were lower in the patients with depression compared to non-depressed subjects (SMD [95%CI] = -0.60 [-1.10 to -0.10]). Physical training had an immediate positive effect on the BDNF levels and not statistically significant effect in the long term; SMD [95%CI] = 0.49 [0.09 to 0.88]) and SMD [95%CI] = 0.02 [-0.43 to 0.47]). Lastly, rTMS showed no effect on the level of BDNF with 0.00 SMD. Conclusions This study confirms that stroke significantly affects the level of BDNF in various domains such as cognition, affect, and motor function. We believe that BDNF could be regarded as a valuable diagnostic biomarker for acute stroke and a potential prognostic biomarker for depression and cognitive deficits.

scholarly journals Brain-derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) study

2008 ◽  
Vol 1 (2) ◽  
pp. 130-137 ◽  
Author(s):  
Lisa A. Croen ◽  
Paula Goines ◽  
Daniel Braunschweig ◽  
Robert Yolken ◽  
Cathleen K. Yoshida ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Peripheral Blood ◽  
Brain Derived Neurotrophic Factor ◽  
Blood Levels ◽  
Early Markers

scholarly journals Peripheral blood levels of brain-derived neurotrophic factor in patients with post-traumatic stress disorder (PTSD): A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241928
Author(s):  
Helia Mojtabavi ◽  
Amene Saghazadeh ◽  
Leigh van den Heuvel ◽  
Joana Bucker ◽  
Nima Rezaei
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Neurotrophic Factor ◽  
Stress Disorder ◽  
Meta Analysis ◽  
Sandwich Elisa ◽  
Brain Derived Neurotrophic Factor ◽  
Blood Levels ◽  
Post Traumatic Stress ◽  
Post Traumatic

Background Brain-derived neurotrophic factor (BDNF) plays a crucial role in the survival, differentiation, growth, and plasticity of the central nervous system (CNS). Post-traumatic stress disorder (PTSD) is a complex syndrome that affects CNS function. Evidence indicates that changes in peripheral levels of BDNF may interfere with stress. However, the results are mixed. This study investigates whether blood levels of BDNF in patients with post-traumatic stress disorder (PTSD) are different. Methods We conducted a systematic search in the major electronic medical databases from inception through September 2019 and identified Observational studies that measured serum levels of BDNF in patients with PTSD compared to controls without PTSD. Results 20 studies were eligible to be included in the present meta-analysis. Subjects with PTSD (n = 909) showed lower BDNF levels compared to Non-PTSD controls (n = 1679) (SMD = 0.52; 95% confidence interval: 0.18 to 0.85). Subgroup meta-analyses confirmed higher levels of BDNF in patients with PTSD compared to non-PTSD controls in plasma, not serum, and in studies that used sandwich ELISA, not ELISA, for BDNF measurement. Meta-regressions showed no significant effect of age, gender, NOS, and sample size. Conclusions PTSD patients had increased serum BDNF levels compared to healthy controls. Our finding of higher BDNF levels in patients with PTSD supports the notion that PTSD is a neuroplastic disorder.

Brain derived neurotrophic factor signaling and clinical symptoms in anorexia nervosa

2017 ◽  
Vol 27 ◽  
pp. S1098-S1099
Author(s):  
F. Rybakowski ◽  
M. Skibinska ◽  
M. Dmitrzak-Weglarz ◽  
A. Slopien ◽  
M. Tyszkiewicz-Nwafor
Keyword(s):  
Anorexia Nervosa ◽  
Neurotrophic Factor ◽  
Clinical Symptoms ◽  
Brain Derived Neurotrophic Factor ◽  
Neurotrophic Factor Signaling
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