Axonal Transport of Horseradish Peroxidase in the Experimental Tethered Spinal Cord

1989 ◽  
Vol 15 (6) ◽  
pp. 296-301 ◽  
Author(s):  
Takaharu Fuse ◽  
John W. Patrickson ◽  
Shokei Yamada
Keyword(s):  
Spinal Cord ◽  
Horseradish Peroxidase ◽  
Axonal Transport ◽  
Tethered Spinal Cord

Effects of Vincristine on Endothelial Microtubules in the Spinal Cord

1976 ◽  
Vol 34 ◽  
pp. 58-59
Author(s):  
John L. Beggs ◽  
John D. Waggener ◽  
Wanda Miller
Keyword(s):  
Spinal Cord ◽  
Biological Activity ◽  
Horseradish Peroxidase ◽  
Transport Mechanism ◽  
Vasogenic Edema ◽  
Vesicular Transport ◽  
Close Proximity

Microtubules (MT) are versatile organelles participating in a wide variety of biological activity. MT involvement in the movement and transport of cytoplasmic components has been well documented. In the course of our study on trauma-induced vasogenic edema in the spinal cord we have concluded that endothelial vesicles contribute to the edema process. Using horseradish peroxidase as a vascular tracer, labeled endothelial vesicles were present in all situations expected if a vesicular transport mechanism was in operation. Frequently,labeled vesicles coalesced to form channels that appeared to traverse the endothelium. The presence of MT in close proximity to labeled vesicles sugg ested that MT may play a role in vesicular activity.

scholarly journals The Role of Axonal Transport in Neurodegenerative Disease Spread: A Meta-Analysis of Experimental and Clinical Poliomyelitis Compares with Amyotrophic Lateral Sclerosis

1991 ◽  
Vol 18 (S3) ◽  
pp. 435-438 ◽  
Author(s):  
Benjamin Rix Brooks
Keyword(s):  
Spinal Cord ◽  
Axonal Transport ◽  
Neuronal Degeneration ◽  
Meta Analysis ◽  
Gender Effects ◽  
The Other ◽  
Disease Spread ◽  
Local Spread ◽  
Other Hand ◽  
Bulbar Onset

ABSTRACT:ALS symptom spread results from local spread of the neuronal degeneration because contiguous areas are more quickly involved than non-contiguous areas. Local spread to contiguous areas of motor neuron dysfunction is faster at the brainstem, cervical and lumbar regions than spread to non-continguous areas. The time for caudal-rostral symptomatic spread of ALS to involve a distant region is a function of the distance of that region from the site of onset. The time for spread to the bulbar region is shorter following arm onset than leg onset. Spread to non-contiguous areas is faster within the spinal cord than from the spinal cord to the bulbar region. These kinetics are consistent with axonal transport of the etiological agent in a manner similar to spread of poliovirus in poliomyelitis patients. Spread from the bulbar region to the spinal cord, on the other hand, occurs faster than symptom spread from the limb region to the bulbar region in limb onset patients. This rapid limb involvement following bulbar onset is more dramatic in males compared with females. Females with leg onset, on the other hand, show more rapid involvement of the opposite leg, either arm or bulbar structures than males. Gender effects may determine the course of ALS depending on the original site of onset.

An EM analysis of the synaptic connections of horseradish peroxidase-filled stalked cells and islet cells in the substantia gelatinosa of adult cat spinal cord

1980 ◽  
Vol 194 (4) ◽  
pp. 781-807 ◽  
Author(s):  
Stephen Gobel ◽  
William M. Falls ◽  
Gary J. Bennett ◽  
Mohammed Abdelmoumene ◽  
Haruhide Hayashi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Horseradish Peroxidase ◽  
Islet Cells ◽  
Substantia Gelatinosa ◽  
Synaptic Connections ◽  
Adult Cat

Spine-shortening vertebral osteotomy in a patient with tethered cord syndrome and a vertebral fracture

2008 ◽  
Vol 9 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Haruo Kanno ◽  
Toshimi Aizawa ◽  
Hiroshi Ozawa ◽  
Takeshi Hoshikawa ◽  
Eiji Itoi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Vertebral Fracture ◽  
Rare Case ◽  
Tethered Cord ◽  
Conus Medullaris ◽  
Tethered Cord Syndrome ◽  
Bone Union ◽  
Tethered Spinal Cord ◽  
Fracture Fragment ◽  
Loss Of Correction

The authors report a rare case of tethered cord syndrome with low-placed conus medullaris complicated by a vertebral fracture that was successfully treated by a spine-shortening vertebral osteotomy. The patient was a 57-year-old woman whose neurological condition worsened after a T-12 vertebral fracture because a fracture fragment and the associated local kyphotic deformity directly compressed the tethered spinal cord. An osteotomy of the T-12 vertebra was performed in order to correct the kyphosis, remove the fracture fragment, and reduce the tension on the spinal cord. Postoperative radiographs showed the spine to be shortened by 22 mm, and the kyphosis between T-11 and L-1 improved from 23° to 0°. Two years after the surgery, the patient's neurological symptoms were resolved. The bone union was complete with no loss of correction.

Parabrachial nucleus neurons projecting to the lower brain stem and the spinal cord. A study in the cat by the Fink-Heimer and the horseradish peroxidase methods

1980 ◽  
Vol 70 (2) ◽  
pp. 403-413 ◽  
Author(s):  
Yoshiki Takeuchi ◽  
Masanori Uemura ◽  
Kojyuro Matsuda ◽  
Ryotaro Matsushima ◽  
Noboru Mizuno
Keyword(s):  
Spinal Cord ◽  
Horseradish Peroxidase ◽  
Brain Stem ◽  
Parabrachial Nucleus ◽  
Lower Brain Stem
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