Catalase, Superoxide Dismutase and Glutathione Peroxidase Activity in Neutrophils of Sham-Operated and Olfactory-Bulbectomised Rats following Chronic Treatment with Desipramine and Lithium Chloride

1994 ◽  
Vol 30 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Cai Song ◽  
A.A. Killeen ◽  
B.E. Leonard
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Lithium Chloride ◽  
Peroxidase Activity ◽  
Chronic Treatment ◽  
Glutathione Peroxidase Activity

scholarly journals Effects of estrogens and androgens on erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase activities during the menstrual cycle

2000 ◽  
Vol 167 (3) ◽  
pp. 447-452 ◽  
Author(s):  
C Massafra ◽  
D Gioia ◽  
C De Felice ◽  
E Picciolini ◽  
V De Leo ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Menstrual Cycle ◽  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Free Testosterone ◽  
Cycle Phase ◽  
Activity Levels ◽  
Glutathione Peroxidase Activity ◽  
Antioxidant Enzyme System ◽  
Peroxidase Enzyme

The effects of physiological changes in estrogens and androgens on the erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase enzyme activities during the menstrual cycle were investigated in healthy eumenorrheic women. Blood samples were taken on alternate days from twelve normally cyclic women (age range: 20 to 27 years; mean age: 24.1 years) from the first day of one menstrual cycle until the first day of the subsequent one. Plasma was analyzed for FSH, LH, estradiol, progesterone, testosterone, free testosterone and androstenedione concentrations. Erythrocyte superoxide dismutase, catalase and glutathione peroxidase activities were evaluated on the same days and cycle length was standardized on the basis of the preovulatory estradiol peak. Significant cyclic phase-related changes were observed in glutathione peroxidase (P<0.05), with higher glutathione peroxidase activity levels from the late follicular to the early luteal phase compared with those found in the early follicular phase (P<0.001 and P<0.002 respectively). A significant positive correlation was observed between mean estradiol and glutathione peroxidase cycle-related variations (r=0.80, P<0.001), whereas no significant cycle phase-dependent changes were seen in superoxide dismutase and catalase. No effect of progesterone and androgens on the erythrocyte antioxidant enzyme system was documented. The findings indicate that physiological ovarian estradiol production during the menstrual cycle may have an important role in regulating erythrocyte glutathione peroxidase activity.

Oxyradical-induced antioxidant and lipid changes in cultured human cardiomyocytes

1994 ◽  
Vol 266 (6) ◽  
pp. H2204-H2211
Author(s):  
R. K. Li ◽  
N. Shaikh ◽  
R. D. Weisel ◽  
W. G. Williams ◽  
D. A. Mickle
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Tetralogy Of Fallot ◽  
Peroxidase Activity ◽  
Membrane Lipid ◽  
Alpha Tocopherol ◽  
Low Oxygen ◽  
Conjugated Diene ◽  
Glutathione Peroxidase Activity ◽  
Human Cardiomyocytes

Because the chronically cyanotic myocardium is thought to be more susceptible to oxyradical injury than the noncyanotic myocardium during cardiovascular surgery, we studied the oxyradical susceptibility of human ventricular cardiomyocytes cultured at high and low oxygen tension (PO2) levels. Passage 4 tetralogy of Fallot cardiomyocytes were cultured at PO2 levels of 150 and 40 mmHg for 14 days and then exposed for 10 min to superoxide radicals. The cellular levels of ATP, phospholipid fatty acids, phospholipid conjugated dienes, alpha-tocopherol, and activities of superoxide dismutase, catalase, and glutathione peroxidase were measured. ATP levels decreased more markedly in the low-PO2 group. Although the decrease in alpha-tocopherol levels was similar for both groups, phospholipid conjugated diene formation and phospholipid unsaturated fatty acid loss was greater in the low-PO2 cells. Glutathione peroxidase activity was rapidly inhibited. Superoxide dismutase activity was unaffected, and catalase activity was inhibited by no more than 50%. Although extracellular superoxide dismutase with catalase did not inhibit phospholipid conjugated diene formation and phospholipid breakdown, extracellular glutathione peroxidase with reduced glutathione did limit phospholipid damage. With the occurrence of membrane lipid peroxidation, the decreased glutathione peroxidase activity in the cyanotic tetralogy of Fallot myocardium determines cardiomyocyte membrane susceptibility to oxidant injury.

scholarly journals Relationship among intracellular superoxide dismutase activity, glutathione peroxidase activity, motility and morphology in human semen

2019 ◽  
Vol 112 (3) ◽  
pp. e263-e264
Author(s):  
Luchezar Vasilev Jelezarski ◽  
Dimitar Parvanov ◽  
Vilyana Georgieva ◽  
Rumiana Ganeva ◽  
Georgi Stamenov Stamenov
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Superoxide Dismutase Activity ◽  
Human Semen ◽  
Glutathione Peroxidase Activity

Superoxide dismutase and glutathione peroxidase activity in hypertensive women

2000 ◽  
Vol 151 (1) ◽  
pp. 61-62
Author(s):  
M Krstevska ◽  
S Dzhekova-Stojkova ◽  
G Bosilkova ◽  
L Trpchevska
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Glutathione Peroxidase Activity
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