The Severe Cognitive Impairment Rating Scale – An Instrument for the Assessment of Cognition in Moderate to Severe Dementia Patients

2008 ◽  
Vol 25 (4) ◽  
pp. 321-328 ◽  
Author(s):  
J.Y. Choe ◽  
J.C. Youn ◽  
J.H. Park ◽  
I.S. Park ◽  
J.W. Jeong ◽  
...  
2008 ◽  
Author(s):  
J. Y. Choe ◽  
J. C. Youn ◽  
J. H. Park ◽  
I. S. Park ◽  
J. W. Jeong ◽  
...  

Dementia ◽  
2017 ◽  
Vol 18 (4) ◽  
pp. 1466-1478 ◽  
Author(s):  
Anja Terkamo-Moisio ◽  
Anna-Maija Pietilä ◽  
Juho T Lehto ◽  
Olli-Pekka Ryynänen

Objectives Despite the increasing prevalence of dementia, little is known about individuals’ attitudes towards euthanasia on patients with dementia or cognitive impairment. Methods Nurses (n = 1003) and representatives of the general public (n = 2796), recruited via social media and the Finnish Nurses Association, completed an electronic questionnaire in 2014. Results Euthanasia due to severe dementia was approved by 54.6% of nurses and 64.4% of the general public. Depending on the age of the patient, between 50.0% and 54.7% of nurses and between 58.3% and 60.9% of the general public supported euthanasia on patients with severe cognitive impairment. Discussion The attitudes towards euthanasia due to dementia or cognitive impairment are slightly more accepting among the general public than among nurses. Apart from religiosity, none of the background factors were found to be reliable predictors of individuals’ attitudes. Additional research is needed to describe the underlying reasons for the attitudes.


The aim of this study was to investigate the correlation between the severity of cognitive impairment in Alzheimer’s disease (AD) and vascular dementia (VD) and the serum antioxidant status of uric acid (UA), albumin (ALB) and bilirubin (BIL) in female patients. The cross-sectional study included 90 subjects, aged ≥65, divided into three groups: 30 patients with AD, 30 patients with VD and 30 control subjects. For cognitive assessment, all participants underwent the Montreal Cognitive Assessment (MoCA). Serum concentrations of ALB, UA and BIL were determined spectrophotometrically. The AD patients had a significant decrease of UA and increase of serum BIL. Upon stratification according to the degree of cognitive impairment, lower UA concentrations were found in patients with severe cognitive impairment, whereas increased BIL was found in patients with moderate cognitive impairment. Patients with VD were characterized by hypoalbuminemia and upon stratification this finding was evident among patients with severe cognitive impairment. The MoCA score correlated positively with BIL in AD patients. The obtained data supports the protective role of serum antioxidants in the pathogenesis of dementia. Further on, we suggest further longitudinal research to confirm the combined use of these parameters as potential biomarkers in AD and VD.


2020 ◽  
Vol 35 ◽  
pp. 153331752093978
Author(s):  
Hannah M. O’Rourke ◽  
Kimberly D. Fraser ◽  
Wendy Duggleby

Little is known about how individual behavioral and psychological symptoms of dementia (BPSD) impact the person with dementia. This cross-sectional, retrospective study examined the association between one BPSD, aggressive behavior, and a patient-identified outcome, sadness, among people with moderate and severe dementia (n = 5001) using clinical administrative Resident Assessment Instrument 2.0 data. For people with moderate or severe cognitive impairment, the odds of sadness were significantly higher if verbal aggression was exhibited 4 to 6 (adjusted odds ratio [aOR] = 2.85, P < .001) or 1 to 3 (aOR = 2.28, P < .001) times per week, or daily (aOR = 1.77, P = .003). People with severe cognitive impairment and who displayed physical aggression either daily (OR = 2.16, P = .002) or 1 to 3 times per week (OR = 1.45, P = .023) also had an increased odds of sadness. Aggression may harm the person with dementia’s mental well-being, depending on the level of cognitive impairment, and type and frequency of aggression. Prospective studies can build on these correlational findings.


2020 ◽  
Vol 35 ◽  
pp. 153331752097078
Author(s):  
Yun Fah Chang ◽  
Woan Yee Loi ◽  
Pai-Yi Chiu ◽  
Huang-Nan Huang

Background/Aims: This study used HAICDDS screening questionnaire to classify the severity of dementia in Taiwan based on the clinical dementia rating scale. Methods: LDA was applied to 6,328 Taiwanese clinical patients for classification purposes. Clustering method was used to identify the associated influential symptoms for each severity level. Result: LDA shows only 36 HAICDDS questions are significant to distinguish the 5 severity levels with 80% overall accuracy and it increased to 85.83% when combining normal and MCI groups. Severe dementia patients have the most serious declination in most cognitive and functionality domains, follows by moderate dementia, mild dementia, MCI and normal patients. Conclusion: HAICDDS is a reliable and time-saved diagnosis tool in classifying the severity of dementia before undergoing a more in-depth clinical examination. The modified CDR may be indicated for epidemiological study and provide a solid foundation to develop a machine-learning derived screening instrument to detect dementia symptoms.


2015 ◽  
Vol 40 (1-2) ◽  
pp. 94-106 ◽  
Author(s):  
Hiroyuki Tanaka ◽  
Yuma Nagata ◽  
Masayasu Uematsu ◽  
Takashi Takebayashi ◽  
Keisuke Hanada ◽  
...  

Background/Aims: Existing cognitive measures for moderate-to-severe dementia have shown floor effects and an inability to assess the remaining cognitive function, especially for profound dementia. Methods: We constructed the Cognitive Test for Severe Dementia (CTSD), which consists of 13 items covering 7 cognitive domains, and examined its reliability and validity. Results: Cronbach's α in severe dementia participants was 0.896. Interrater and test-retest reliability were 0.961 and 0.969, respectively. The CTSD showed a significant correlation with 3 other measures of cognitive function (Mini-Mental State Examination, Severe Cognitive Impairment Rating Scale, and Hasegawa Dementia Scale-Revised: r values = 0.870-0.922, p values <0.001). While the other measures showed floor effects, the CTSD did not. Conclusion: The CTSD was able to sensitively capture the remaining cognitive function in severe dementia patients when compared with other cognitive tests.


2014 ◽  
Vol 26 (7) ◽  
pp. 1139-1145 ◽  
Author(s):  
Shirin Zaidi ◽  
Martin G. Kat ◽  
Jos F.M. de Jonghe

ABSTRACTBackground:Neuropsychiatric symptoms (NPS) are highly prevalent in dementia. The recently developed Neuropsychiatric Inventory – Clinician rating scale (NPI-C) includes clinical judgment and new symptom domains. Our objective was to evaluate NPI-C reliability and to compare caregiver and clinician ratings across the range of mild to severe cognitive impairment.Methods:This is a cross-sectional observational study. Participants were geriatric memory clinic patients and nursing-home residents (n = 30) with an established diagnosis of dementia or Mild Cognitive Impairment (MCI). A psychiatrist (MK) interviewed caregiver–patient dyads using the NPI-C. Neuropsychological tests and Mini-Mental State Examination (MMSE) were used to assess cognitive impairment. Two NPI-C caregiver interviews were videotaped and rated by psychologists and geriatricians. Intra-class correlations (ICCs) were used to examine inter-rater agreement. Correlation coefficients were calculated to evaluate caregiver and psychiatrist NPI-C ratings. Disagreement between caregiver and clinician was expressed in delta scores and examined across the range of mild to severe cognitive impairment, using Levene's homogeneity of variances tests.Results:Inter-rater agreement on ratings of two caregiver videos was high (ICC = 0.99–1.0). Clinician–caregiver concordance on NPI-C total severity ratings was high (r = 0.77). Variability in clinician–caregiver concordance was associated with cognitive impairment: MMSE (P = 0.02), CAMCOG-R (Cambridge Cognitive Examination-revised) total scores (P = 0.02), CAMCOG-R Memory scores (P = 0.04) and Language scores (P = 0.01).Conclusions:The NPI-C is a reliable measure of NPS in patients with MCI or dementia. Clinician–caregiver agreement on NPS severity may vary with cognitive impairment, underlining the importance of clinician-based measures of NPS.


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