Prevalence of Hepatitis E Virus IgG Antibody in Japanese Patients with Hemophilia

Intervirology ◽  
2008 ◽  
Vol 51 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Hidenori Toyoda ◽  
Takashi Honda ◽  
Kazuhiko Hayashi ◽  
Yoshiaki Katano ◽  
Hidemi Goto ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Japanese Patients ◽  
Hepatitis E ◽  
Igg Antibody

scholarly journals Hepatitis E virus infection results in acute graft failure after liver transplantation: a case report

2014 ◽  
Vol 8 (02) ◽  
pp. 245-248 ◽  
Author(s):  
Xiangyan Liu ◽  
Tian Shen ◽  
Zhuoyi Wang ◽  
Li Zhuang ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Failure ◽  
Hepatitis E Virus ◽  
Total Bilirubin Level ◽  
Normal Liver ◽  
Hepatitis E ◽  
Igg Antibody ◽  
Liver Support ◽  
Severe Jaundice ◽  
Acute Graft

Hepatitis E virus (HEV) infection in most individuals is known as a self-limiting, acute, icteric hepatitis, but evidence shows HEV is responsible for choric hepatitis and rapid progressed liver cirrhosis in immuno-compromised patients. We present the case of a patient whose diagnosis of acute graft failure was due to a HEV infection 7 years after his first liver transplantation because of Wilson’s disease. The process showed severe jaundice with fatigue, poor appetite and continually rising serum aminopherase. The blood serum was found positive for the anti-HEV IgG antibody but negative for anti-HEV IgM or other infections. Cholangiole cholestasis was detected in graft biopsy. Triple hepato-protective drugs (Transmetil, Polyene Phosphatidylcholine, and Compound Ammonium Glycyrrhetate S) alongside five times Artificial Liver Support System (ALSS) did not improve the patient’s condition, but the total bilirubin level rose to more than 900umol/L. So re-transplantation was performed. Blood testing shows normal liver enzymes and bilirubin with persisting anti-HEV IgG antibody positive at the 3-month follow-up.

scholarly journals Association of poor virus specific immunoglobulin G antibody responses with higher viral load is seen in Bangladeshi pregnant women having acute Hepatitis E Genotype 1 infection

2020 ◽  
Author(s):  
Rosy Sultana ◽  
Md Tarikul Islam ◽  
Golam Sarower Bhuyan ◽  
Farjana Akther Noor ◽  
Suprovath Kumar Sarker ◽  
...  
Keyword(s):  
Viral Load ◽  
Acute Hepatitis ◽  
Pregnant Women ◽  
South Asian ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Genotype 1 ◽  
Asian Countries ◽  
Igg Antibody ◽  
Acute Hepatitis E

AbstractAlthough Hepatitis E viral illness is usually self-limiting, higher rates of morbidity and mortality are frequently observed during pregnancy in South Asian countries including Bangladesh. Of the four common variants, hepatitis E virus genotype 1 is mainly prevalent in South Asian countries. Pregnant women usually suffer from a state of immunosuppression. It is yet to be known whether virus specific immunoglobulin G (IgG) immune responses have any association with the vulnerability of pregnant women to acute hepatitis with E virus. The study aimed to compare the viral load and IgG responses of hepatitis E-infected pregnant women with that of non-pregnant women with same infection. Real Time –quantitative reverse transcription Polymerase Chain Reaction and Sanger sequencing were performed to determine the viral load and genotype, respectively, whereas Enzyme Linked Immunosorbent Assay method was used to determine hepatitis E virus specific serum IgG antibody index along with IgG avidity index. Although significant negative correlations were observed between log viral copy number and log IgG antibody index in the late acute phases of jaundice for both pregnant (r= −0.7971, p=0.0002) and non-pregnant women (r= −0.9117, p=0.0002), serum log viral copy number of pregnant women was significantly higher than that of the non-pregnant counterpart (p=0.0196) in the late acute stage of jaundice. In addition, log hepatitis E virus IgG antibody index of pregnant women was significantly lower than the non-pregnant women in the late phase of jaundice induced by hepatitis E virus (p=0.0303). Moreover, pregnant women with acute hepatitis E had higher cross-reactive IgG than in the non-pregnant women (p=0.0017). All the patients got infected with hepatitis E virus were in Genotype 1 variety. The study demonstrates that virus-specific poor IgG responses might be responsible for vulnerability of pregnant women to acute hepatitis with hepatitis E virus.Author SummaryAcute hepatitis caused by hepatitis E virus (HEV) Genotype 1 is a public health problem in Asian countries and especially it poses a potential health threat to pregnant women causing 19% to 25% mortality, particularly in South Asian countries including Bangladesh. The study aimed to explore whether HEV IgG immune responses were compromised during pregnancy, which might contribute to higher viral load and disease severity. Accordingly, pregnant and non-pregnant women with acute hepatitis (clinically presented with nausea, loss of appetite and /or jaundice) were enrolled from different tertiary care hospitals in Dhaka city. All these patients were screened and hepatitis E were differentiated from other hepatitis (caused by A, B, C) using Enzyme Linked Immunosorbent Assay (ELISA) methods. HEV IgG antibody/avidity indices and viral loads were measured using ELISA and real time quantitative polymerase chain reaction (RT-qPCR), respectively. The study showed that pregnant women with acute hepatitis E had lower IgG indices with higher viral load than their non-pregnant counterpart. Overall, the study revealed that virus-specific poor IgG responses might render pregnant women vulnerable to acute hepatitis E of varying degree of severity which might be associated with higher viral load.

scholarly journals Hepatitis E virus infection in buffaloes in South China

2020 ◽  
Vol 72 (4) ◽  
pp. 1122-1126
Author(s):  
D. Wei ◽  
Y. Zhao ◽  
Y. Jia ◽  
X. Hao ◽  
J. Situ ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Public Health Issue ◽  
Enzyme Linked Immunosorbent Assay ◽  
Global Public Health ◽  
Igg Antibody ◽  
Nested Polymerase Chain Reaction ◽  
Genotype 4 ◽  
Yellow Cattle ◽  
Polymerase Chain

ABSTRACT Hepatitis E virus (HEV) infection is an important global public health issue. HEV infections are recognized as a zoonotic disease. Swine are believed to be the main reservoir of HEV. Recently, yaks, cows, and yellow cattle have been reported as new reservoirs of HEV. However, whether other species of cattle and buffaloes are sensitive to HEV infection is unknown. To investigate the prevalence of HEV infection in buffaloes, enzyme-linked immunosorbent assay (ELISA) and reverse transcription-nested polymerase chain reaction (RT-nPCR) were performed. Only one buffalo was positive to anti-HEV IgM antibody (1/106, 0.94%), and none were positive for anti-HEV IgG antibody. To our surprise, five serum (5/106, 4.72%) and three milk samples (3/40, 7.50%) from buffaloes were positive to HEV RNA. All strains of HEV isolated from buffaloes belong to genotype 4. Results indicate that buffaloes may be a new reservoir of HEV.

scholarly journals Genetic Heterogeneity of Hepatitis E Virus Recovered from Japanese Patients with Acute Sporadic Hepatitis

2002 ◽  
Vol 185 (9) ◽  
pp. 1342-1345 ◽  
Author(s):  
Kazuaki Takahashi ◽  
Jong‐Hon Kang ◽  
Sachiyo Ohnishi ◽  
Kunihiko Hino ◽  
Shunji Mishiro
Keyword(s):  
Genetic Heterogeneity ◽  
Hepatitis E Virus ◽  
Japanese Patients ◽  
Hepatitis E ◽  
Sporadic Hepatitis ◽  
Acute Sporadic Hepatitis

Short-term IgM and IgG Antibody Responses to Hepatitis E Virus Infection

1996 ◽  
Vol 28 (5) ◽  
pp. 439-441 ◽  
Author(s):  
Abraham Koshy ◽  
Saroj Grover ◽  
Kenneth C. Hyams ◽  
Mohamed A. Shabrawy ◽  
Alexander Pacsa ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Antibody Responses ◽  
Short Term ◽  
Igg Antibody

Serological survey on hepatitis E virus infection in an endemic area: diagnosis potential of enzyme immunoassay for detection of IgG antibody

1994 ◽  
Vol 2 (4-5) ◽  
pp. 297-304 ◽  
Author(s):  
M.S. Balayan ◽  
N.A. Zamyatina ◽  
M.I. Mikhailov ◽  
A.V. Sychev ◽  
R.K. Usmanov ◽  
...  
Keyword(s):  
Virus Infection ◽  
Enzyme Immunoassay ◽  
Hepatitis E Virus ◽  
Endemic Area ◽  
Hepatitis E ◽  
Serological Survey ◽  
Igg Antibody

scholarly journals IgG antibody response demonstrates inverse correlation with viral load in Bangladeshi women with acute hepatitis E virus genotype 1 infection

2021 ◽  
Vol 104 ◽  
pp. 482-490
Author(s):  
Rosy Sultana ◽  
Md Tarikul Islam ◽  
Golam Sarower Bhuyan ◽  
Suprovath Kumar Sarker ◽  
Farjana Akther Noor ◽  
...  
Keyword(s):  
Viral Load ◽  
Antibody Response ◽  
Acute Hepatitis ◽  
Hepatitis E Virus ◽  
Inverse Correlation ◽  
Hepatitis E ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Igg Antibody ◽  
Acute Hepatitis E

Hepatitis E Virus in LeberBiopsien von Patienten mit akuter Hepatitis unbekannter Ätiologie

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
C Dorloff ◽  
J Hemberger ◽  
M Odenthal ◽  
H Holzmann ◽  
S Aberle ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E
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