Morphology and Epidermal Thickness of Normal Skin Imaged by Optical Coherence Tomography

Dermatology ◽  
2008 ◽  
Vol 217 (1) ◽  
pp. 14-20 ◽  
Author(s):  
Mette Mogensen ◽  
Hanan A. Morsy ◽  
Lars Thrane ◽  
Gregor B.E. Jemec
Keyword(s):  
Optical Coherence Tomography ◽  
Normal Skin ◽  
Optical Coherence ◽  
Epidermal Thickness

In vivodetermination of epidermal thickness using high-definition optical coherence tomography

2014 ◽  
Vol 170 (3) ◽  
pp. 737-739 ◽  
Author(s):  
T. Gambichler ◽  
K. Valavanis ◽  
I. Plura ◽  
D. Georgas ◽  
P. Kampilafkos ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Epidermal Thickness ◽  
High Definition

scholarly journals Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis

2013 ◽  
Vol 306 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Olubukola Babalola ◽  
Andrew Mamalis ◽  
Hadar Lev-Tov ◽  
Jared Jagdeo
Keyword(s):  
Optical Coherence Tomography ◽  
Normal Skin ◽  
Skin Fibrosis ◽  
Optical Coherence

scholarly journals Use of Vibrational Optical Coherence Tomography to Characterize Skin Lesions and a Congenital Nevus

2019 ◽  
Vol 2 (4) ◽  
pp. 109-118
Author(s):  
H Silver Frederick ◽  
◽  
G Shah Ruchit ◽  
Kelkar Nikita ◽  
◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Near Infrared ◽  
Normal Skin ◽  
Skin Lesions ◽  
Melanocytic Nevus ◽  
Infrared Light ◽  
Optical Coherence ◽  
Congenital Nevus

We have used vibrational optical coherence tomography (VOCT) to image and measure the mechanical properties of normal skin and skin lesions. It is observed that in a congenital nevus and normal skin, the cellular epidermis is qualitatively not as bright as in skin lesions including basal cell carcinoma, actinic keratosis and a melanocytic nevus. Melanin and cytochrome c oxidase are reported to attenuate the reflection of near-infrared light at a wavelength of 810 nm and therefore may explain the reduced reflection of light in a congenital nevus and normal skin under conditions where cytochrome c oxidase levels would be expected to be high. Our results suggest that the melanin and cytochrome c oxidase levels found in congenital nevus and skin lesions may influence the observed pixel density observed in OCT images. For this reason, a correction for the content of these components in the skin must be considered before quantitative pixel measurements can be correctly interpreted. Additional measurements of pixel density along with the moduli of cellular and collagenous components in skin and skin lesions are needed to further interpret the significance of “virtual biopsies” made using VOCT.

LIGHT-INDUCED FLUORESCENCE SPECTROSCOPY AND OPTICAL COHERENCE TOMOGRAPHY OF BASAL CELL CARCINOMA

2009 ◽  
Vol 02 (03) ◽  
pp. 261-268 ◽  
Author(s):  
EKATERINA BORISOVA ◽  
ELFRIDA CARSTEA ◽  
LUMINITA CRISTESCU ◽  
ELMIRA PAVLOVA ◽  
NIKOLAY HADJIOLOV ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Fluorescence Spectroscopy ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Normal Skin ◽  
Biological Tissues ◽  
Skin Lesions ◽  
Optical Coherence

Many up-to-date optical techniques have been developed and applied recently in clinical practice for obtaining qualitatively and quantitatively new data from the investigated lesions. Due to their high sensitivity in detection of small changes, these techniques are widely used for detection of early changes in biological tissues. Light-induced fluorescence spectroscopy (LIFS) is one of the most promising techniques for early detection of cutaneous neoplasia. Increasing number of recent publications have suggested that optical coherence tomography (OCT) also has potential for non-invasive diagnosis of skin cancer. This recent work is a part of clinical trial procedure for introduction of LIFS technique into the common medical practice in National Oncological Medical Center in Bulgaria for diagnosis of non-melanoma skin cancer. We focus our attention here on basal cell carcinoma lesions and their specific features revealed by LIFS and OCT analysis. In this paper we prove the efficiency of using the combined LIFS-OCT method in skin lesions studies by integrating the complimentary qualities of each particular technique. For LIFS measurements several excitation sources, each emitting at 365, 385 and 405 nm maxima are applied. An associated microspectrometer detects in vivo the fluorescence signals from human skin. The main spectral features of the lesions and normal skin are discussed and their possible origins are indicated. OCT images are used to evaluate the lesion thickness, structure and severity stage, when possible. The obtained results could be used to develop a more complete picture of optical properties of these widely spread skin disorders. At the same time, our studies show that the combined LIFS-OCT method could be introduced in clinical algorithms for early tumor detection and differentiation between normal/benign/malignant skin lesions.

scholarly journals In vivo response of GsdmA3Dfl/+ mice to topically applied anti-psoriatic agents: effects on epidermal thickness, as determined by optical coherence tomography and H&E staining

2011 ◽  
Vol 20 (3) ◽  
pp. 269-272 ◽  
Author(s):  
Mohd Hanif Zulfakar ◽  
Aneesh Alex ◽  
Boris Povazay ◽  
Wolfgang Drexler ◽  
Christopher P. Thomas ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Epidermal Thickness
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