Effect of Pimozide on Positive and Negative Symptoms in Schizophrenic Patients: Are Negative Symptoms State Dependent?

1987 ◽  
Vol 18 (3) ◽  
pp. 113-117 ◽  
Author(s):  
Daniel P. van Kammen ◽  
Daniel W. Hommer ◽  
Kenneth L Malas
Keyword(s):  
Negative Symptoms ◽  
State Dependent ◽  
Schizophrenic Patients ◽  
Positive And Negative Symptoms

Negative Symptoms at Discharge and Outcome in Schizophrenia

1995 ◽  
Vol 166 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Hai-Gwo Hwu ◽  
Happy Tan ◽  
Chu-Chang Chen ◽  
Ling-Ling Yeh
Keyword(s):  
Clinical Outcome ◽  
Social Functioning ◽  
Symptom Score ◽  
Negative Symptoms ◽  
Positive Symptom ◽  
Positive Symptoms ◽  
Symptom Scores ◽  
Schizophrenic Patients ◽  
Positive And Negative Symptoms

BackgroundThe clinical significance in schizophrenia of positive and negative symptoms at discharge was assessed.MethodOf schizophrenic patients fulfilling DSM–III criteria, 113 were recruited for this study. Personal, social and psychopathological data were collected and all cases were followed up at one and two years after discharge.ResultsThe presence of positive symptoms (64 cases), without concomitant negative symptoms, did not predict the follow-up social function and positive symptom score. Conversely, the presence of negative symptoms (31 cases) predicted worse social functioning (P < 0.05 to P < 0.005) and higher positive symptom scores (P < 0.01) at follow-up using MANOVA. Eighteen cases (15.9%) had neither positive nor negative symptoms and had the best clinical outcome.ConclusionsNegative, but not positive, symptoms assessed at discharge are an important predictor of poor outcome. In addition, negative symptoms may themselves expose a biological vulnerability to the presence of positive symptoms.

Positive and Negative Symptoms in Psychiatry

1986 ◽  
Vol 148 (5) ◽  
pp. 587-589 ◽  
Author(s):  
Michael R. Trimble
Keyword(s):  
Negative Symptoms ◽  
Geographical Location ◽  
Personal Communication ◽  
Thought Disorder ◽  
Positive Symptom ◽  
Positive Symptoms ◽  
Market Research Company ◽  
Research Company ◽  
Schizophrenic Patients ◽  
Positive And Negative Symptoms

The terms positive and negative symptoms have slipped into the language of contemporary psychiatry with comparative ease. It is not uncommon for these expressions to be used with little explanation, both at meeting and in written communications, with the implicit understanding that their meaning is understood and that somehow they are of value to our knowledge of psychopathology. However, that there are no clear guide-lines at present for our use of these terms is shown from a recent survey of psychiatrists' opinions from a market research company (Martin Hamblin Research-Personal Communication). As part of a series of questions asked to many psychiatrists of differing age, geographical location, and status, they were asked about the meaning of these terms, positive and negative symptoms and the proportion of schizophrenic patients having them. Of the categories quoted by Crow (1980–81) as positive symptoms, 68% considered that delusions were positive symptoms, 63% hallucinations, and only 35% thought disorder. In contrast, 18% thought that behaviour disturbance was a positive symptom, a similar figure (15%) being given for passivity feelings. Considerable variation was noted, however, with hallucinations being considered positive by only 33% of London psychiatrists, thought disorder by only 11% of those qualified 16–25 years, and one-quarter of all registrars and psychiatrists from Midland Health Districts considered passivity feelings to fall into this category. Even greater disagreement was recorded for negative symptoms. Thus, the symptom most often associated with this category was apathy, by 52% of respondents. Only 26% considered that withdrawal was a negative symptom, the percentage data for lack of motivation and blunting of affect being 37% and 15% respectively.

Three Syndromes in Chronic Schizophrenia

1989 ◽  
Vol 155 (S7) ◽  
pp. 119-122 ◽  
Author(s):  
P.F. Liddle ◽  
Thomas R.E. Barnes ◽  
D. Morris ◽  
S. Haque
Keyword(s):  
Cognitive Impairment ◽  
Clinical Features ◽  
Negative Symptoms ◽  
Chronic Schizophrenia ◽  
Brain Abnormalities ◽  
Brain Abnormality ◽  
Schizophrenic Patients ◽  
Extensive Body ◽  
Positive And Negative Symptoms

In recent years, exploration of the distinction between positive and negative symptoms of schizophrenia has provided a fruitful basis for attempts to relate the clinical features of schizophrenia to the accumulating evidence of brain abnormalities in schizophrenic patients. By 1982, there was an extensive body of evidence supporting the hypothesis that negative schizophrenic symptoms, such as poverty of speech and flatness of affect, were associated with substantial brain abnormalities, such as increased ventricular to brain ratio, and extensive cognitive impairment (Crow, 1980; Andreasen & Olsen, 1982). However, at that stage there were several fundamental unanswered questions about the nature of negative symptoms, and their relationship to indices of brain abnormality. This paper presents some findings of a series of studies initiated in 1982 to seek answers to some of these questions.

Dissociative Symptoms in Schizophrenic Patients with Positive and Negative Symptoms

1997 ◽  
Vol 30 (2) ◽  
pp. 67-75 ◽  
Author(s):  
Carsten Spitzer ◽  
Hans-Joachim Haug ◽  
Harald J. Freyberger
Keyword(s):  
Negative Symptoms ◽  
Dissociative Symptoms ◽  
Schizophrenic Patients ◽  
Positive And Negative Symptoms

The Effect of Humor Intervention Program on Positive and Negative Symptoms among Schizophrenic Patients

2021 ◽  
Vol 15 (7) ◽  
pp. 2022-2028
Author(s):  
Eman Asran Mohamed ◽  
Enayat Abd El Wahab Khalil ◽  
Zeinab Abd El Halim Osman ◽  
Mona Rakhawy ◽  
Naglaa Mostafa G
Keyword(s):  
Intervention Program ◽  
Negative Symptoms ◽  
Demographic Data ◽  
Intervention Group ◽  
University Hospital ◽  
Control Group ◽  
Significant Difference ◽  
Schizophrenic Patients ◽  
And Control ◽  
Positive And Negative Symptoms

Background: Schizophrenia is a chronic disease characterized by distortions in thinking, perception, emotions, language, sense of self and behavior. Humor could be used as an alternative to conventional treatment with the goal of helping patients with schizophrenia cope with symptoms, enhance recovery through its emotional, cognitive, social and physiological effects. The aim of the study was to evaluate the effect of humor intervention program on positive and negative symptoms among schizophrenic patients. Design: Randomized control trial (RCT) design was used. Sample: Purposive sample consisted of 40) schizophrenic patients, the study group (n= 20) and control group (n= 20). The patients were selected and allocated randomly into two groups, intervention group (received the humor interventions program) and control group (received traditional care). The study conducted in the Psychiatry and Addiction Prevention "El Kasr AlAini University Hospital and al Rakhawy Hospital for Mental Health. Tools: three tools were used for data collection were; the Socio Demographic Data Sheet, Positive and Negative Syndrome Scale (PANSS) and Multidimensional Sense of Humor Scale (MSHS). Results: revealed that, there was a statistical significant difference between total score of PANSS between study and control groups post intervention. Conclusion: The present study emphasizes the importance of humor intervention program in reducing severity of symptoms of patients with schizophrenia. Key words: schizophrenia, humor intervention, positive symptoms, negative symptoms

Generality and specificity of emotion-recognition deficit in schizophrenic patients with positive and negative symptoms

1999 ◽  
Vol 87 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Manas K. Mandal ◽  
Anuradha Jain ◽  
S. Haque-Nizamie ◽  
Ute Weiss ◽  
Frank Schneider
Keyword(s):  
Emotion Recognition ◽  
Negative Symptoms ◽  
Schizophrenic Patients ◽  
Positive And Negative Symptoms

The Assessment of Negative and Positive Features in Schizophrenia

1989 ◽  
Vol 155 (S7) ◽  
pp. 41-44 ◽  
Author(s):  
Eve C. Johnstone
Keyword(s):  
Negative Symptoms ◽  
Normal Function ◽  
Thought Disorder ◽  
List Type ◽  
Type Number ◽  
Formal Thought Disorder ◽  
Clinical Correlates ◽  
Schizophrenic Patients ◽  
The Relationship ◽  
Positive And Negative Symptoms

It has become customary to classify the typical abnormalities of the mental state of schizophrenic patients into positive and negative features, with reference to behavioural excesses and deficits. Positive features are pathological by their presence and negative features represent the loss of some normal function. Positive features are generally considered to include delusions, hallucinations and positive formal thought disorder (Fish, 1962). Some studies (e.g. Johnstone et al, 1978) have also included incongruity of affect under this heading. Negative features include affective flattening, poverty of speech, retardation, apathy, lack of sociability. There is some evidence that the clinical correlates of positive and negative features may not be the same (Owens & Johnstone, 1980). Some workers (Andreasen & Olsen, 1982) but not others (Pogue-Geile & Harrow, 1984) have found that among schizophrenic patients positive and negative symptoms were negatively correlated. Although the nature of the relationship between positive and negative features is not entirely established and may not be simple (Wing, 1978) certain generalisations may be applied: (a)Positive features are characteristic of earlier and negative of later phases of the illness (Pfohl & Winokur, 1982).(b)The effects of drugs upon positive features are greater than those upon negative features. Thus neuroleptics produce more marked improvement (Johnstone et al, 1978; Angrist et al, 1980) and amphetamine more marked exacerbation (Angrist et al, 1980) of positive than of negative features.(c)Positive features have been said to be relatively variable and negative features relatively stable (Ovchinnikov, 1968; Snezhnevsky, 1968).

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