Semi-Late Onset and Rapidly Progressive Case of Lafora’s Disease with Predominant Cognitive Symptoms

1989 ◽  
Vol 29 (6) ◽  
pp. 333-338 ◽  
Author(s):  
Pierre Genton ◽  
Michel Borg ◽  
Piernanda Vigliano ◽  
Jean-François Pellissier ◽  
Joseph Roger
Keyword(s):  
Late Onset ◽  
Cognitive Symptoms ◽  
Lafora's Disease

Vitamin D Levels, APOE Allele, and MRI Volumetry Assessed by NeuroQuant in Norwegian Adults with Cognitive Symptoms

2021 ◽  
Vol 79 (1) ◽  
pp. 311-321
Author(s):  
Jelena Zugic Soares ◽  
Renate Pettersen ◽  
Jūratė Šaltytė Benth ◽  
Karin Persson ◽  
Carsten Strobel ◽  
...  
Keyword(s):  
Vitamin D ◽  
Late Onset ◽  
Apoe Genotype ◽  
Serum Levels ◽  
Grey Matter Volume ◽  
Cognitive Symptoms ◽  
Cross Sectional ◽  
Brain Volumes ◽  
Vitamin D Levels ◽  
Mri Volumetry

Background: Allele ɛ4 of the apolipoprotein (APOE ∈4) gene is the strongest known genetic risk factor for late-onset sporadic Alzheimer’s disease. A possible relationship between vitamin D and APOE is not yet clear. Objective: In this exploratory, cross-sectional study, we examined the association between serum levels of 25-hydroxyvitamin D [25(OH)D] and brain volumes and the associations of both serum levels of 25(OH)D and APOE polymorphism to brain volumes in 127 persons (mean age 66 years) with cognitive symptoms. Methods: All subjects were examined with fully automated software for MRI volumetry, NeuroQuant. Results: After adjustment for relevant covariates, higher serum 25(OH)D levels were associated with greater volumes of cortical gray matter on both left (p = 0.02) and right (p = 0.04) sides. When both 25(OH)D levels and APOE genotype were used as the main covariates, no significant associations were found between vitamin D level and brain volume in any of the 11 brain regions. In adjusted models, only homozygous but not heterozygous APOE ∈4 allele carriers had significantly larger inferior lateral ventricles (p = 0.003) and smaller hippocampal volume (p = 0.035) than those without ɛ4. Homozygous APOE ∈4 carriers also had significantly higher vitamin D levels (p = 0.009) compared to persons without the APOE ∈4 allele. Conclusion: Higher vitamin D levels might have a preserving effect on cortical grey matter volume.

O3-11-01: Non-cognitive symptoms in early- and late-onset dementia

2015 ◽  
Vol 11 (7S_Part_5) ◽  
pp. P243-P244
Author(s):  
Shilpa Sadanand ◽  
Prafulla Shivakumar ◽  
Srikala Bharath ◽  
Rakesh Balachandar ◽  
Palanimuthu Thangaraju Sivakumar ◽  
...  
Keyword(s):  
Late Onset ◽  
Cognitive Symptoms ◽  
Late Onset Dementia

Late-onset Lafora's disease with typical intraneuronal inclusions

Neurology ◽  
1993 ◽  
Vol 43 (6) ◽  
pp. 1246-1246 ◽  
Author(s):  
M. A. Kaufman ◽  
A. J. Dwork ◽  
N. J. Willson ◽  
S. John ◽  
J. D. Liu
Keyword(s):  
Late Onset ◽  
Lafora's Disease

Seizures Can Precede Cognitive Symptoms in Late-Onset Alzheimer's Disease

2011 ◽  
Vol 27 (4) ◽  
pp. 737-742 ◽  
Author(s):  
Agnese Picco ◽  
Silvana Archetti ◽  
Michela Ferrara ◽  
Dario Arnaldi ◽  
Alessandra Piccini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Onset ◽  
Cognitive Symptoms

Apolipoprotein E: non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease

1997 ◽  
Vol 63 (2) ◽  
pp. 273b-273b ◽  
Author(s):  
C. BALLARD ◽  
H. MASSEY ◽  
H. LAMB ◽  
C. MORRIS; ◽  
C. HOLMES ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Apolipoprotein E ◽  
Late Onset ◽  
Cognitive Symptoms

scholarly journals A new case of late onset Lafora's disease without generalised seizures

1999 ◽  
Vol 66 (1) ◽  
pp. 114a-116a ◽  
Author(s):  
A FERNANDEZ-BARREIRO ◽  
J S. GUILLEN ◽  
P C. VERA ◽  
J M. FERNANDEZ ◽  
J B E. SORIANO ◽  
...  
Keyword(s):  
Late Onset ◽  
Lafora's Disease

Late-Onset Anaphylaxis to Omalizumab Reported

2006 ◽  
Vol 37 (6) ◽  
pp. 6
Author(s):  
PATRICE WENDLING
Keyword(s):  
Late Onset
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