Cerebral Oxygen Consumption in the Rat: Pharmacological Stimulation and Suppression, Role of Catecholaminergic Mechanisms

1981 ◽  
Vol 20 (3) ◽  
pp. 215-218 ◽  
Author(s):  
R. Hemmingsen ◽  
D.I. Barry
Keyword(s):  
Oxygen Consumption ◽  
Cerebral Oxygen ◽  
Cerebral Oxygen Consumption ◽  
Pharmacological Stimulation ◽  
Catecholaminergic Mechanisms

Influence of endogenous norepinephrine on cerebral blood flow and metabolism

1976 ◽  
Vol 231 (2) ◽  
pp. 489-494 ◽  
Author(s):  
ET MacKenzie ◽  
J McCulloch ◽  
AM Harper
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Oxygen Consumption ◽  
Glucose Uptake ◽  
Cerebral Circulation ◽  
Brain Metabolism ◽  
Cerebral Metabolism ◽  
Cerebral Oxygen ◽  
Brain Norepinephrine ◽  
Cerebral Oxygen Consumption

The influence of brain norepinephrine on cerebral metabolism and blood flow was examined because exogenous norepinephrine, administered in a way that the blood-brain barrier is bypassed, has been shown to effect pronounced changes in the cerebral circulation. Reserpine (40 mug/kg, by intracarotid infusion) was administered in order to release brain norepinephrine in five anesthetized baboons. Reserpine significantly increased cerebral oxygen consumption (23%) and cerebral blood flow (50%). This response lasted for approximately 60 min. In a further five animals, effects of central beta-adrenoreceptor blockade were studied. Pro pranolol (12 mug/kg-min) produced an immediate, significant reduction in both cerebral oxygen consumption (40%) and cerebral glucose uptake (39%). Cerebral blood flow was reduced minimally. However, the responsiveness of the cerebral circulation to induced hypercapnia was severely attenuated from a gradient of 3.22 before, to 1,11 after, administration. These experiments suggest that central norepinephrine can influence the cerebral circulation primarily through noradrenergic effects on brain metabolism.

scholarly journals Acute‐stage MRI cerebral oxygen consumption biomarkers predict 24‐hour neurological outcome in a rat cardiac arrest model

2020 ◽  
Vol 33 (11) ◽  
Author(s):  
Zhiliang Wei ◽  
Qihong Wang ◽  
Hiren R. Modi ◽  
Sung‐Min Cho ◽  
Romergryko Geocadin ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Oxygen Consumption ◽  
Neurological Outcome ◽  
Acute Stage ◽  
Cerebral Oxygen ◽  
Cerebral Oxygen Consumption

Cerebral Blood Flow and Cerebral Oxygen Consumption during Nitroprusside-induced Hypotension to Less than 50 mmHg

1989 ◽  
Vol 70 (2) ◽  
pp. 255-260 ◽  
Author(s):  
Michel Pinaud ◽  
Réml Souron ◽  
Jean-Noël Lelausque ◽  
Marie-France Gazeau ◽  
Youenn Lajat ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Oxygen Consumption ◽  
Cerebral Oxygen ◽  
Induced Hypotension ◽  
Cerebral Oxygen Consumption

Effect of morphine on regional cerebral oxygen consumption and supply

1984 ◽  
Vol 291 (2) ◽  
pp. 301-308 ◽  
Author(s):  
E. Buchweitz ◽  
L. Grandison ◽  
H.R. Weiss
Keyword(s):  
Oxygen Consumption ◽  
Cerebral Oxygen ◽  
Cerebral Oxygen Consumption
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