Cyclic Nucleotides in Progressive Muscular Dystrophy

1979 ◽  
Vol 18 (5) ◽  
pp. 356-360 ◽  
Author(s):  
Shozo Kito ◽  
Miyuki Yamamoto ◽  
Eiko Itoga ◽  
Takenobu Kishida
Keyword(s):  
Muscular Dystrophy ◽  
Cyclic Nucleotides ◽  
Progressive Muscular Dystrophy

Biochemical changes in progressive muscular dystrophy. XII. Cyclic nucleotides in lymphoid and nonlymphoid organs of dystrophic mice

1986 ◽  
Vol 64 (12) ◽  
pp. 1339-1348 ◽  
Author(s):  
Manohar Thakur ◽  
Mikael Sebag ◽  
Uma Srivastava
Keyword(s):  
Skeletal Muscle ◽  
Muscular Dystrophy ◽  
Cyclic Nucleotides ◽  
Significant Variation ◽  
Lymphoid Organs ◽  
Immune Responsiveness ◽  
Sharp Decline ◽  
Progressive Muscular Dystrophy ◽  
Camp And Cgmp ◽  
Dystrophic Mice

Concentrations of cAMP and cGMP were measured (per milligram DNA) in the lymphoid (thymus, spleen) and nonlymphoid organs (liver, brain, kidney, lungs, heart, pancreas, skeletal muscle, lens) of normal (+/+) and dystrophic (dy/dy) 129 ReJ mice aged 30, 60, and 90 days. The cAMP concentrations in the thymus did not reveal any significant differences at 30 and 60 days of dystrophy, but were considerably higher (2-fold) at 90 days. cGMP concentrations were decreased in the thymus at 30 days (0.20-fold) and markedly elevated at 60 (2-fold) and 90 days (3-fold) of the disease. The [cAMP]/[cGMP] ratio was increased (1.30-fold) at 30 days of dystrophy, and this was followed by a sharp decline at 60 days (2-fold), with a lesser decrease at 90 days (0.34-fold). In the spleen, the cAMP concentrations were augmented significantly in all stages of dystrophy (1.5- to 2.6-fold). cGMP (per milligram DNA) did not show any significant variation at 30 and 60 days of the disease but was increased (3-fold) at 90 days. The [cAMP]/[cGMP] ratio, which was enhanced in the spleen at 30 (2-fold) and 60 days (1.5-fold), demonstrated no change at 90 days of dystrophy. These results indicated significant differences in the concentration of cyclic nucleotides and their ratios in the thymus and spleen of 129 ReJ dy/dy mice. The modifications were not limited to lymphoid organs alone, having been noted in the nonlymphoid organs as well. These changes could, in turn, influence immune responsiveness and could cause immunodepression in dystrophic mice.

Biochemical changes in progressive muscular dystrophy. XI. Cyclic nucleotides in the skeletal and cardiac muscle of normal and dystrophic mice

1981 ◽  
Vol 59 (4) ◽  
pp. 329-334 ◽  
Author(s):  
Uma Srivastava ◽  
Mikael Sebag ◽  
Manohar Thakur
Keyword(s):  
Skeletal Muscle ◽  
Muscular Dystrophy ◽  
Cardiac Muscle ◽  
Cyclic Nucleotides ◽  
Dystrophic Muscle ◽  
Camp Content ◽  
Progressive Muscular Dystrophy ◽  
Camp And Cgmp ◽  
Dystrophic Mice ◽  
Murine Dystrophy

cAMP and cGMP contents were determined in the skeletal and cardiac muscle of normal and dystrophic mice. cAMP content increased in the dystrophic muscle at every stage of the disease whereas cGMP content decreased in the preliminary stages and increased at the terminal stage of the disease. The content of both nucleotides per heart was not affected in murine dystrophy. Thus, levels of cyclic nucleotides appear to be selectively altered in dystrophic skeletal muscle.

scholarly journals Analysis of Self-Consciousness Using Self-Rating Scales in Children with Duchenne Progressive Muscular Dystrophy and Asthma

1989 ◽  
Vol 27 (3) ◽  
pp. 45-54
Author(s):  
Akihiko OGASAWARA ◽  
Kazumi KOHMURA ◽  
Mitsuhiro MIYAZAKI ◽  
Youichi USHIDA ◽  
Shingo YAMAUCHI
Keyword(s):  
Muscular Dystrophy ◽  
Rating Scales ◽  
Progressive Muscular Dystrophy ◽  
Self Rating

Urinary excretion of carnitine in progressive muscular dystrophy

Nature ◽  
1974 ◽  
Vol 249 (5453) ◽  
pp. 173-174 ◽  
Author(s):  
M. MAEBASHI ◽  
N. KAWAMURA ◽  
K. YOSHINAGA
Keyword(s):  
Muscular Dystrophy ◽  
Urinary Excretion ◽  
Progressive Muscular Dystrophy
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