scholarly journals Lymphocyte Subsets and the Role of Th1/Th2 Balance in Stressed Chronic Pain Patients

2007 ◽  
Vol 14 (5) ◽  
pp. 272-280 ◽  
Author(s):  
Ines Kaufmann ◽  
Christoph Eisner ◽  
Peter Richter ◽  
Volker Huge ◽  
Antje Beyer ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Lymphocyte Subsets ◽  
Chronic Pain Patients ◽  
Pain Patients

scholarly journals Response of Chronic Pain Patients to Terrorism: The Role of Underlying Depression

Pain Medicine ◽  
2007 ◽  
Vol 8 (5) ◽  
pp. 425-432 ◽  
Author(s):  
Mario Moric ◽  
Asokumar Buvanendran ◽  
Timothy R. Lubenow ◽  
Amit Mehta ◽  
Jeffrey S. Kroin ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Chronic Pain Patients ◽  
Pain Patients

scholarly journals Central Nervous System Targets: Inhibitory Interneurons in the Spinal Cord

2020 ◽  
Vol 17 (3) ◽  
pp. 874-885 ◽  
Author(s):  
David I Hughes ◽  
Andrew J Todd
Keyword(s):  
Chronic Pain ◽  
Sensory Information ◽  
Protective Role ◽  
Inhibitory Interneurons ◽  
Pathological Conditions ◽  
Pain Pathways ◽  
Chronic Pain Patients ◽  
Cortical Regions ◽  
Pain Patients

Abstract Pain is a percept of critical importance to our daily survival. In most cases, it serves both an adaptive function by helping us respond appropriately in a potentially hostile environment and also a protective role by alerting us to tissue damage. Normally, it is evoked by the activation of peripheral nociceptive nerve endings and the subsequent relay of information to distinct cortical and sub-cortical regions, but under pathological conditions that result in chronic pain, it can become spontaneous. Given that one in three chronic pain patients do not respond to the treatments currently available, the need for more effective analgesics is evident. Two principal obstacles to the development of novel analgesic therapies are our limited understanding of how neuronal circuits that comprise these pain pathways transmit and modulate sensory information under normal circumstances and how these circuits change under pathological conditions leading to chronic pain states. In this review, we focus on the role of inhibitory interneurons in setting pain thresholds and, in particular, how disinhibition in the spinal dorsal horn can lead to aberrant sensory processing associated with chronic pain states.

scholarly journals God Image and Happiness in Chronic Pain Patients: The Mediating Role of Disease Interpretation

Pain Medicine ◽  
2010 ◽  
Vol 11 (5) ◽  
pp. 765-773 ◽  
Author(s):  
Jessie Dezutter ◽  
Koen Luyckx ◽  
Hanneke Schaap-Jonker ◽  
Arndt Büssing ◽  
Jozef Corveleyn ◽  
...  
Keyword(s):  
Chronic Pain ◽  
God Image ◽  
Mediating Role ◽  
Chronic Pain Patients ◽  
Pain Patients
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