Brain Glutamic Acid Decarboxylase Activity in Parkinson’s Disease

U.K. Rinne; H. Laaksonen; P. Riekkinen; V. Sonninen

doi:10.1159/000114599

Brain Glutamic Acid Decarboxylase Activity in Parkinson’s Disease

European Neurology ◽

10.1159/000114599 ◽

1974 ◽

Vol 12 (1) ◽

pp. 13-19 ◽

Cited By ~ 30

Author(s):

U.K. Rinne ◽

H. Laaksonen ◽

P. Riekkinen ◽

V. Sonninen

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Glutamic Acid ◽

Glutamic Acid Decarboxylase ◽

Acid Decarboxylase ◽

Decarboxylase Activity

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Normal glutamic decarboxylase activity in rat striatum and retina following administration of L-DOPA

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y76-013 ◽

1976 ◽

Vol 54 (2) ◽

pp. 79-82 ◽

Cited By ~ 4

Author(s):

G. Tunnicliff ◽

R. F. Butterworth ◽

Y. Tsukada ◽

A. Barbeau

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Glutamic Acid ◽

Glutamic Acid Decarboxylase ◽

Rat Striatum ◽

Acid Decarboxylase ◽

Decarboxylase Activity ◽

Gad Activity

Recent reports of the in vivo action of L-dihydroxyphenylalanine (L-DOPA) on glutamic acid decarboxylase (GAD) activity are contradictory. This investigation was undertaken to clarify the situation. Both acute (100 mg/kg and 1 g/kg) and chronic (1 g/kg) administration of L-DOPA to rats failed to produce any alteration in the activity of striatal or retinal GAD activity. These results are discussed in the light of a report relating L-DOPA therapy to modification of GAD activity in Parkinson's disease.

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Effects of globus pallidus lesions and Parkinson's disease on brain glutamic acid decarboxylase

Brain Research ◽

10.1016/0006-8993(71)90334-9 ◽

1971 ◽

Vol 32 (2) ◽

pp. 425-431 ◽

Cited By ~ 125

Author(s):

P.L. McGeer ◽

E.G. McGeer ◽

J.A. Wada ◽

E. Jung

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Glutamic Acid ◽

Globus Pallidus ◽

Glutamic Acid Decarboxylase ◽

Acid Decarboxylase

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L-Glutamic Acid Decarboxylase in Parkinson's Disease: Effect of L-Dopa Therapy

Nature ◽

10.1038/243521a0 ◽

1973 ◽

Vol 243 (5409) ◽

pp. 521-523 ◽

Cited By ~ 113

Author(s):

K. G. LLOYD ◽

O. HORNYKIEWICZ

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Glutamic Acid ◽

Glutamic Acid Decarboxylase ◽

Acid Decarboxylase ◽

Disease Effect

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Glutamic acid decarboxylase in Parkinson's disease and epilepsy

Neurology ◽

10.1212/wnl.21.10.1000 ◽

1971 ◽

Vol 21 (10) ◽

pp. 1000-1000 ◽

Cited By ~ 66

Author(s):

P. L. McGeer ◽

E. G. McGeer ◽

J. A. Wada

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Glutamic Acid ◽

Glutamic Acid Decarboxylase ◽

Acid Decarboxylase

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Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease

Experimental Neurology ◽

10.1016/j.expneurol.2010.09.001 ◽

2010 ◽

Vol 226 (1) ◽

pp. 207-217 ◽

Cited By ~ 31

Author(s):

Amélie C. Lanoue ◽

Alexandra Dumitriu ◽

Richard H. Myers ◽

Jean-Jacques Soghomonian

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Prefrontal Cortex ◽

Glutamic Acid ◽

Mrna Expression ◽

Glutamic Acid Decarboxylase ◽

Acid Decarboxylase

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GLUTAMIC-ACID DECARBOXYLASE AND CHOLINE ACETYLASE IN HUNTINGTON'S CHOREA AND PARKINSON'S DISEASE

The Lancet ◽

10.1016/s0140-6736(73)92461-6 ◽

1973 ◽

Vol 302 (7829) ◽

pp. 623-624 ◽

Cited By ~ 21

Author(s):

P MCGEER

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Glutamic Acid ◽

Glutamic Acid Decarboxylase ◽

Acid Decarboxylase ◽

Huntington's Chorea ◽

Choline Acetylase

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Glutamic acid decarboxylase in cerebrospinal fluid in infancy and childhood part II. Glutamic acid decarboxylase activity in cerebrospinal fluid of children with neurological diseases

Brain and Development ◽

10.1016/s0387-7604(83)80080-1 ◽

1983 ◽

Vol 5 (5) ◽

pp. 488-493 ◽

Cited By ~ 1

Author(s):

Hideyo Tada

Keyword(s):

Cerebrospinal Fluid ◽

Glutamic Acid ◽

Glutamic Acid Decarboxylase ◽

Neurological Diseases ◽

Acid Decarboxylase ◽

Decarboxylase Activity ◽

Infancy And Childhood

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Hepatic encephalopathy in cirrhotic and portacaval shunted dogs: Lack of changes in brain GABA uptake, brain GABA levels, brain glutamic acid decarboxylase activity and brain postsynaptic GABA receptors

Hepatology ◽

10.1002/hep.1840080424 ◽

1988 ◽

Vol 8 (4) ◽

pp. 845-849 ◽

Cited By ~ 41

Author(s):

Sophie Roy ◽

Gilles Pomier-Layrargues ◽

Roger F. Butterworth ◽

P.-Michel Huet

Keyword(s):

Hepatic Encephalopathy ◽

Glutamic Acid ◽

Glutamic Acid Decarboxylase ◽

Gaba Receptors ◽

Acid Decarboxylase ◽

Gaba Uptake ◽

Decarboxylase Activity ◽

Brain Gaba

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Effect of cyclic analogues of valproic acid on glutamic acid decarboxylase activity as determined by different methods

Phytochemistry ◽

10.1016/s0031-9422(00)82458-9 ◽

1987 ◽

Vol 26 (12) ◽

pp. 3141-3144 ◽

Cited By ~ 2

Author(s):

Manohar L. Sethi ◽

Kenneth R. Scott ◽

Andrew A. Acheampong

Keyword(s):

Valproic Acid ◽

Glutamic Acid ◽

Glutamic Acid Decarboxylase ◽

Acid Decarboxylase ◽

Decarboxylase Activity

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Pharmacological studies on the effects of drugs and the amino acid metabolism (Report 2). Effects of diazepam and pentazocine on the L-glutamic acid decarboxylase activity in isolated rabbit organs

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)58961-2 ◽

1986 ◽

Vol 40 ◽

pp. 69

Author(s):

Toyoo Tanaka ◽

Minoru Makino ◽

Kenji Ishii ◽

Joichi Ando

Keyword(s):

Amino Acid ◽

Glutamic Acid ◽

Glutamic Acid Decarboxylase ◽

Amino Acid Metabolism ◽

Acid Metabolism ◽

Acid Decarboxylase ◽

Decarboxylase Activity ◽

Pharmacological Studies

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