Pathophysiological Aspects of the Blood Brain Barrier Change in Acute Arterial Hypertension

1971 ◽  
Vol 6 (1-6) ◽  
pp. 24-28 ◽  
Author(s):  
E. Häggendal ◽  
B. Johansson
1983 ◽  
Vol 58 (3) ◽  
pp. 338-344 ◽  
Author(s):  
Eric W. Peterson ◽  
Erico R. Cardoso

✓ In three groups of cats, the authors studied the effect of subarachnoid hemorrhage (SAH) on the permeability of the blood-brain barrier (BBB) to the penetration of Evans blue-protein complex. One group received arterial hypertension alone, one group SAH alone, and one group SAH followed by arterial hypertension. Animals subjected to arterial hypertension alone showed areas of BBB breakdown. However, when cats were rendered hypertensive after SAH, there were no demonstrable BBB lesions. The SAH was produced by intracisternal injection of whole blood and hypertension by the intravenous injection of metaraminol. The preservation of the BBB after SAH is discussed. Vasospasm is considered as a possible hemodynamic variable responsible for the protection of the BBB from hypertensive damage. The need for a new model is proposed to further investigate the state of the BBB after SAH.


Author(s):  
B. Ekström-Jodal ◽  
E. Häggendal ◽  
B. Johansson ◽  
L.-E. Linder ◽  
N. J. Nilsson

1970 ◽  
Vol 16 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Barbro Johansson ◽  
Choh-Luh Li ◽  
Yngve Olsson ◽  
Igor Klatzo

1978 ◽  
Vol 49 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Alain Forster ◽  
Kathleen Van Horn ◽  
Lawrence F. Marshall ◽  
Harvey M. Shapiro

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