scholarly journals Role of Aberrant Glycosylation of IgA1 Molecules in the Pathogenesis of IgA Nephropathy

2008 ◽  
Vol 31 (1) ◽  
pp. 29-37 ◽  
Author(s):  
J. Mestecky ◽  
M. Tomana ◽  
Z. Moldoveanu ◽  
B.A. Julian ◽  
H. Suzuki ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Aberrant Glycosylation

scholarly journals Role of the intestinal MALT in pathogenesis of the IgA-nephropathy

2021 ◽  
Vol 93 (6) ◽  
pp. 724-728
Author(s):  
Sergei V. Guliaev ◽  
Leonid A. Strizhakov ◽  
Natalia V. Chebotareva ◽  
Sergei V. Moiseev
Keyword(s):  
Iga Nephropathy ◽  
Intestinal Permeability ◽  
Treatment Modalities ◽  
Intestinal Diseases ◽  
System Activity ◽  
Aberrant Glycosylation ◽  
Future Treatment ◽  
Modern View

Modern view on pathogenesis of immunoglobulin (Ig)A-nephropathy and possible relation to intestinal MALT-system activity is presented in the article. Aberrant glycosylation of IgA and increased association of IgA-nephropathy with intestinal diseases or abnormal intestinal permeability are discussed in details. Based on supposed entero-renal pathogenesis of the disease future treatment modalities are considered. Relevant worlds literature is cited.

scholarly journals Experimental evidence of pathogenic role of IgG autoantibodies in IgA nephropathy

2021 ◽  
Vol 118 ◽  
pp. 102593
Author(s):  
Zina Moldoveanu ◽  
Hitoshi Suzuki ◽  
Colin Reily ◽  
Kenji Satake ◽  
Lea Novak ◽  
...  
Keyword(s):  
Experimental Evidence ◽  
Iga Nephropathy ◽  
Pathogenic Role

Enumerating the role of properdin in the pathogenesis of IgA nephropathy and its possible therapies

2021 ◽  
Vol 93 ◽  
pp. 107429
Author(s):  
Srijit Ghosh ◽  
Srijita Das ◽  
Joy Mukherjee ◽  
Salik Abdullah ◽  
Rupsa Mondal ◽  
...  
Keyword(s):  
Iga Nephropathy

The role of tonsillectomy in IgA nephropathy

2015 ◽  
Vol 29 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Sandro Feriozzi ◽  
Rosaria Polci
Keyword(s):  
Iga Nephropathy

Questionable Role of Soy Protein in Childhood IgA Nephropathy

Nephron ◽  
1993 ◽  
Vol 64 (3) ◽  
pp. 395-398 ◽  
Author(s):  
T. Murakami ◽  
H. Kawakami
Keyword(s):  
Iga Nephropathy ◽  
Soy Protein ◽  
Childhood Iga Nephropathy

scholarly journals Reduced fecal short-chain fatty acids levels and the relationship with gut microbiota in IgA nephropathy

2021 ◽  
Author(s):  
Lingxiong Chai ◽  
Qun Luo ◽  
Kedan Cai ◽  
Kaiyue Wang ◽  
Binbin Xu
Keyword(s):  
Gut Microbiota ◽  
Iga Nephropathy ◽  
Butyric Acid ◽  
Intestinal Flora ◽  
Short Chain Fatty Acids ◽  
Caproic Acid ◽  
Isobutyric Acid ◽  
Control Group ◽  
Β Diversity

Abstract Background: IgA nephropathy(IgAN)) is the common pathological type of glomerular diseases. The role of gut microbiota in mediating "gut-IgA nephropathy" has not received sufficient attention in the previous studies. The purpose of this study was to investigate the changes of fecal short-chain fatty acids(SCFAs), a metabolite of the intestinal microbiota, in patients with IgAN and its correlation with intestinal flora and clinical indicators, and to further investigate the role of the gut-renal axis in IgAN.Methods: There were 29 patients with IgAN and 29 normal control subjects recruited from January 2018 to May 2018. The fresh feces were collected. The fecal SCFAs were measured by gas chromatography/mass spectrometry and gut microbiota was analysed by16S rDNA sequences, followed by estimation of α- and β-diversity. Correlation analysis was performed using the spearman’s correlation test between SCFAs and gut microbiota. Results:The levels of acetic acid, propionic acid, butyric acid, isobutyric acid and caproic acid in the IgAN patients were significantly reduced compared with control group(P<0.05). Butyric acid(r=-0.336, P=0.010) and isobutyric acid(r=-0.298, P=0.022) were negatively correlated with urea acid; butyric acid(r=-0.316, P=0.016) was negatively correlated with urea nitrogen; caproic acid(r=-0.415,P=0.025) showed negative correlation with 24-h urine protein level.Exemplified by the results of α-diversity and β-diversity, the intestinal flora of IgAN patients was significantly different from that of the control group. Acetic acid was positively associated with c_Clostridia(r=0.357, P=0.008), o_Clostridiales(r=0.357, P=0.008) and g_Eubacterium_coprostanoligenes_group(r=0.283, P=0.036). Butyric acid was positively associated with g_Alistipes (r=0.278, P=0.040). The relative abundance of those were significantly decreased in IgAN group compared to control group.Conclusion: The levels of fecal SCFAs in the IgAN patients were reduced, and correlated with clinical parameters and gut microbiota, which may be involved in the pathogenesis of IgAN, and this finding may provide a new therapeutic approach.

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