The c.1-260C>T Promoter Variant of CD14 but Not the c.896A>G (p.D299G) Variant of Toll-Like Receptor 4 (TLR4) Genes Is Associated with Inflammatory Bowel Disease

Digestion ◽  
2007 ◽  
Vol 76 (3-4) ◽  
pp. 196-202 ◽  
Author(s):  
Daniel C. Baumgart ◽  
Carsten Büning ◽  
Lars Geerdts ◽  
Hartmut H. Schmidt ◽  
Janine Genschel ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Inflammatory Bowel

CARD15 and Toll-like receptor 4 mutations in Italian patients with inflammatory bowel disease

2012 ◽  
Vol 44 (9) ◽  
pp. 800-801 ◽  
Author(s):  
Danila Guagnozzi ◽  
Cristiano Pagnini ◽  
Gianfranco Delle Fave ◽  
Vito Domenico Corleto
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Inflammatory Bowel

Lack of association between toll-like receptor 4 haplotype and Asp299gly polymorphism and susceptibility for inflammatory bowel disease

2003 ◽  
Vol 124 (4) ◽  
pp. A372-A373 ◽  
Author(s):  
Liekele E. Oostenbrug ◽  
Dirk De Jong ◽  
Joost P.H. Drenth ◽  
Ilja Nolte ◽  
Hendrik Van Dullemen ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Inflammatory Bowel

scholarly journals The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis

2015 ◽  
Vol 309 (7) ◽  
pp. G517-G527 ◽  
Author(s):  
Gaiyan Ren ◽  
Aning Sun ◽  
Chao Deng ◽  
Jingjing Zhang ◽  
Xiaojun Wu ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Protein Kinase ◽  
Bowel Disease ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Mitogen Activated Protein Kinase ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Mitogen Activated Protein ◽  
Inflammatory Bowel

Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. However, the direct effect of cardamonin on intestinal inflammation remains elusive. In the present study, we found that cardamonin markedly ameliorated dextran sulfate sodium-induced mouse body weight loss, diarrhea, colon shortening, spleen swelling, and histological damage, which correlated with a decline in the activity of myeloperoxidase and the production of nitric oxide, tumor necrosis factor-α and interleukin-6 in the colon. The upregulation of toll-like receptor 4 after dextran sulfate sodium treatment was associated with an increase in the activation of myeloid differentiation factor 88, interleukin-1 receptor-associated kinase-1, nuclear factor-κB (NF-κB) p65, inhibitor κBα, and inhibitor κB kinase-α/β, as well as the mitogen-activated protein kinase molecules of extracellular signal-regulated kinase and c-Jun NH2-terminal kinase, and this upregulation was reversed by cardamonin administration. Moreover, cardamonin blocked the nuclear translocation of NF-κB p65, inhibited NF-κB-luciferase activity, and downregulated NF-κB target genes expression. The present study clearly demonstrates a beneficial effect of cardamonin on experimental inflammatory bowel disease via a mechanism associated with suppression of toll-like receptor 4 expression and inactivation of NF-κB and mitogen-activated protein kinase pathways. This study may give insight into the further evaluation of the therapeutic potential of cardamonin or its derivatives for human inflammatory bowel disease.

Association Between Toll-like Receptor 4 and Inflammatory Bowel Disease

2005 ◽  
Vol 11 (6) ◽  
pp. 567-575 ◽  
Author(s):  
Liekele E Oostenbrug ◽  
Joost P. H. Drenth ◽  
Dirk J de Jong ◽  
Ilja M Nolte ◽  
Elvira Oosterom ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Inflammatory Bowel
Sign in / Sign up

Export Citation Format

Share Document