Dietary Modulators of Peroxisome Proliferator-Activated Receptors: Implications for the Prevention and Treatment of Metabolic Syndrome

2008 ◽  
Vol 1 (3) ◽  
pp. 126-135 ◽  
Author(s):  
Amir J. Guri ◽  
Raquel Hontecillas ◽  
Josep Bassaganya-Riera
Keyword(s):  
Metabolic Syndrome ◽  
Peroxisome Proliferator ◽  
Prevention And Treatment ◽  
Peroxisome Proliferator Activated Receptors

scholarly journals Screening of Peroxisome Proliferator-activated Receptors (PPARs) α, γ and δ Gene Polymorphisms for Obesity and Metabolic Syndrome Association in the Multi-ethnic Malaysian Population

2015 ◽  
Vol 25 (4) ◽  
pp. 383 ◽  
Author(s):  
Phee-Phee Chia ◽  
Sook-Ha Fan ◽  
Yee-How Say
Keyword(s):  
Metabolic Syndrome ◽  
Demographic Data ◽  
Plasma Lipid ◽  
Peroxisome Proliferator ◽  
Nucleotide Polymorphisms ◽  
Ethnic Population ◽  
Single Nucleotide ◽  
Peroxisome Proliferator Activated Receptor ◽  
Ethnic Chinese ◽  
Peroxisome Proliferator Activated Receptors

<p class="Pa7"><strong>Objective: </strong>This study aimed to investigate the association of peroxisome proliferator-activated receptor (PPAR) genes <em>PPAR</em>α L162V, <em>PPAR</em><em>γ</em><em>2 </em>C161T and <em>PPAR</em><em>δ </em>T294C single nucleotide polymorphisms (SNPs) with obesity and metabolic syndrome (Met- S) in a multi-ethnic population in Kampar, Malaysia.</p><p class="Pa7"><strong>Methods: </strong>Socio-demographic data, anthropometric and biochemical measure­ments (plasma lipid profile, adiponectin and interleukin-6 [IL-6] levels) were taken from 307 participants (124 males; 180 obese; 249 Met-S; 97 Malays, 85 ethnic Chinese, 55 ethnic Indians).</p><p class="Pa7"><strong>Results: </strong>The overall minor allele frequen­cies were .08, .22 and .30 for <em>PPAR </em>α L162V, γ C161T, δ T294C, respectively. All SNPs were not associated with obesity, Met-S and obesity with/without Met-S by χ2 analysis, ethnicity-stratified and logistic re­gression analyses. Nevertheless, participants with V162 allele of <em>PPAR</em><em>α </em>had significantly higher IL-6, while those with T161 allele of <em>PPAR</em><em>γ</em><em>2 </em>had significantly lower HOMA-IR.</p><p><strong>Conclusions: </strong>All <em>PPAR </em>SNPs were not associated with obesity and Met-S in the suburban population of Kampar, Malay­sia, where only <em>PPAR</em><em>α </em>V162 and <em>PPAR</em><em>γ</em><em>2 </em>T161 alleles were associated with plasma IL-6 and HOMA-IR, respectively. <em>Ethn Dis. </em>2015;25(4):383-390; doi:10.18865/ ed.25.4.383</p>

scholarly journals Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome

2021 ◽  
Vol 22 (16) ◽  
pp. 8939
Author(s):  
Agustina Cano-Martínez ◽  
Rocío Bautista-Pérez ◽  
Vicente Castrejón-Téllez ◽  
Elizabeth Carreón-Torres ◽  
Israel Pérez-Torres ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Liver Damage ◽  
Purinergic Receptor ◽  
Critical Role ◽  
Hepatocyte Proliferation ◽  
Peroxisome Proliferator ◽  
Ppar Alpha ◽  
Nonalcoholic Fatty Liver ◽  
Beneficial Effects ◽  
Peroxisome Proliferator Activated Receptors

Nonalcoholic fatty liver disease (NAFLD) is considered a manifestation of metabolic syndrome (MS) and is characterized by the accumulation of triglycerides and a varying degree of hepatic injury, inflammation, and repair. Moreover, peroxisome-proliferator-activated receptors (PPARs) play a critical role in the pathophysiological processes in the liver. There is extensive evidence of the beneficial effect of polyphenols such as resveratrol (RSV) and quercetin (QRC) on the treatment of liver pathology; however, the mechanisms underlying their beneficial effects have not been fully elucidated. In this work, we show that the mechanisms underlying the beneficial effects of RSV and QRC against inflammation in liver damage in our MS model are due to the activation of novel pathways which have not been previously described such as the downregulation of the expression of toll-like receptor 4 (TLR4), neutrophil elastase (NE) and purinergic receptor P2Y2. This downregulation leads to a decrease in apoptosis and hepatic fibrosis with no changes in hepatocyte proliferation. In addition, PPAR alpha and gamma expression were altered in MS but their expression was not affected by the treatment with the natural compounds. The improvement of liver damage by the administration of polyphenols was reflected in the normalization of serum transaminase activities.

scholarly journals Peroxisome Proliferator-Activated Receptors - Alpha in Chronic Inflammation - Mini-Review

2019 ◽  
Vol 12 ◽  
pp. 1-11
Author(s):  
Elena Popa ◽  
Florin Zugun-Eloae ◽  
Mihaela Zlei ◽  
Maria Traian ◽  
Agnes Bacusca ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Transcription Factors ◽  
Lipid Metabolism ◽  
Visceral Obesity ◽  
Peroxisome Proliferator ◽  
Proinflammatory Response ◽  
The Metabolic Syndrome ◽  
Metabolic Complication ◽  
Peroxisome Proliferator Activated Receptors ◽  
Proinflammatory Factors

The pathogeny of the metabolic syndrome (MetS ) is not fully elucidated, but a link between visceral obesity and the increase of the proinflammatory response was proven. Atherosclerosis, perceived as a metabolic complication, draws attention to the peroxisome proliferator-activated receptors- alpha (PPARα). PPARα receptors are transcription factors involved in lipid metabolism, inflammation and atheromatosis. Hence, it interferes in the pathogeny of cardiovascular diseases and other chronic diseases too (neurological, psychical, neoplasical). The study of the expression of PPARα and its modulation on different level may be beneficial in the treatment of metabolic syndrome, intervening in the modulation of another proinflammatory factors.

scholarly journals Trace Elements, PPARs, and Metabolic Syndrome

2020 ◽  
Vol 21 (7) ◽  
pp. 2612 ◽  
Author(s):  
Yujie Shi ◽  
Yixin Zou ◽  
Ziyue Shen ◽  
Yonghong Xiong ◽  
Wenxiang Zhang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Trace Elements ◽  
Mrna Expression ◽  
High Fat Diet ◽  
Binding Activity ◽  
Peroxisome Proliferator ◽  
Dna Binding Activity ◽  
Ppar Γ ◽  
Peroxisome Proliferator Activated Receptors ◽  
Structure Of Proteins

Metabolic syndrome (MetS) is a constellation of metabolic derangements, including central obesity, insulin resistance, hypertension, glucose intolerance, and dyslipidemia. The pathogenesis of MetS has been intensively studied, and now many factors are recognized to contribute to the development of MetS. Among these, trace elements influence the structure of proteins, enzymes, and complex carbohydrates, and thus an imbalance in trace elements is an independent risk factor for MetS. The molecular link between trace elements and metabolic homeostasis has been established, and peroxisome proliferator-activated receptors (PPARs) have appeared as key regulators bridging these two elements. This is because on one hand, PPARs are actively involved in various metabolic processes, such as abdominal adiposity and insulin sensitivity, and on the other hand, PPARs sensitively respond to changes in trace elements. For example, an iron overload attenuates hepatic mRNA expression of Ppar-α; zinc supplementation is considered to recover the DNA-binding activity of PPAR-α, which is impaired in steatotic mouse liver; selenium administration downregulates mRNA expression of Ppar-γ, thereby improving lipid metabolism and oxidative status in the liver of high-fat diet (HFD)-fed mice. More importantly, PPARs’ expression and activity are under the control of the circadian clock and show a robust 24 h rhythmicity, which might be the reasons for the side effects and the clinical limitations of trace elements targeting PPARs. Taken together, understanding the casual relationships among trace elements, PPARs’ actions, and the pathogenesis of MetS is of great importance. Further studies are required to explore the chronopharmacological effects of trace elements on the diurnal oscillation of PPARs and the consequent development of MetS.

scholarly journals Cardiometabolic syndrome: How important is PPARy receptor activation for clinical practice?

2008 ◽  
Vol 14 (2) ◽  
pp. 116-124 ◽  
Author(s):  
A. Barsukov
Keyword(s):  
Metabolic Syndrome ◽  
Total Mortality ◽  
Receptor Activation ◽  
Cardiovascular Complications ◽  
Peroxisome Proliferator ◽  
Metabolic Risk ◽  
Risk Patients ◽  
Peroxisome Proliferator Activated Receptors ◽  
Genetic And Environmental Factors ◽  
Cardio Vascular

Resume Interaction of genetic and environmental factors, metabolic and vascular disturbances increases the risk of total mortality, renal dysfunction, cardiovascular complications. Insulin resistance plays the key role in metabolic syndrome development. Connection of renin-angiotensin-aldosterone system (RAAS) and metabolic risk factors has been carefully studied. Peroxisome proliferator-activated receptors г (PPARг) role in fatty and carbohydrate metabolism is being studied intensively nowadays. Thiazolidinediones impact on cardio-vascular prognosis is controversial, and needs subsequent research. Pleiotropic effects of RAAS-blockers play important role in treatment of high risk patients. Telmisartan, being a partial PPARг-agonist, extends perspective rational pharmacotherapy of hypertension in patients with metabolic syndrome.

Sign in / Sign up

Export Citation Format

Share Document