Chronic Kidney Disease as a Risk Factor for Coronary Artery Disease in Chinese with Type 2 Diabetes

2007 ◽  
Vol 28 (2) ◽  
pp. 317-323 ◽  
Author(s):  
Ming-Chia Hsieh ◽  
Jeng-Yueh Hsiao ◽  
Kai-Jen Tien ◽  
Shun-Jen Chang ◽  
Shih-Chieh Hsu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Chronic Kidney Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Artery Disease

418-P: Chronic Kidney Disease Is a Type 2 Diabetes Risk Equivalent in Patients with Established Coronary Artery Disease

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 418-P
Author(s):  
CHRISTOPH H. SAELY ◽  
LUKAS SPRENGER ◽  
ALEXANDER VONBANK ◽  
BARBARA LARCHER ◽  
ARTHUR MADER ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Chronic Kidney Disease ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Diabetes Risk ◽  
Established Coronary Artery Disease ◽  
Artery Disease ◽  
Risk Equivalent

scholarly journals Haptoglobin phenotypes as a risk factor for coronary artery disease in type 2 diabetes mellitus: An Egyptian study

2014 ◽  
Vol 15 (3) ◽  
pp. 257-264 ◽  
Author(s):  
Gehan Hamdy ◽  
Olfat M. Hendy ◽  
Hala Mahmoud ◽  
Azza El-sebaey ◽  
Salwa R. Ali ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Coronary Artery ◽  
Artery Disease

scholarly journals Functional Gly297Ser Variant of the Physiological Dysglycemic Peptide Pancreastatin is a Novel Risk Factor for Cardiometabolic Disorders

2021 ◽  
Author(s):  
Prasanna K. R. Allu ◽  
Malapaka Kiranmayi ◽  
Sromona D. Mukherjee ◽  
Venkat R. Chirasani ◽  
Richa Garg ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Human Populations ◽  
Wild Type ◽  
Cardiometabolic Disorders ◽  
Artery Disease ◽  
Variant Peptide

Pancreastatin (PST), a chromogranin A (CHGA)-derived potent physiological dysglycemic peptide, regulates glucose/insulin homeostasis. We have identified a non-synonymous functional PST variant (p.Gly297Ser; rs9658664) that occurs in a large section of human populations. Association analysis of this single nucleotide polymorphism with cardiovascular/metabolic diseases states in Indian populations (n≈4300 subjects) displays elevated plasma glucose, glycosylated hemoglobin, diastolic blood pressure and catecholamines in Gly/Ser subjects as compared to wild-type individuals (Gly/Gly). Consistently, the 297Ser allele confers an increased risk (~1.3-1.6-fold) for type-2 diabetes/hypertension/coronary artery disease/metabolic syndrome. In corroboration, the variant peptide (PST-297S) displays gain-of-potency in several cellular events relevant for cardiometabolic disorders (<i>e.g.</i>, increased expression of gluconeogenic genes, increased catecholamine secretion, greater inhibition of insulin-stimulated glucose-uptake) than the wild-type peptide (PST-WT). Computational docking analysis and molecular dynamics simulations show higher affinity binding of PST-297S peptide with glucose-regulated protein 78 (GRP78) and insulin receptor (IR) than PST-WT, providing a mechanistic basis for the enhanced activity of the variant peptide. <i>In vitro</i> binding assays validate these <i>in silico</i> predictions of PST peptides binding to GRP78 and IR. In conclusion, the PST 297Ser allele influences cardiovascular/metabolic phenotypes and emerges as a novel risk factor for type-2 diabetes/hypertension/coronary artery disease in human populations.

scholarly journals Migraine as a Risk Factor for Peripheral Artery Occlusive Disease: A Population-Based Cohort Study

2020 ◽  
Vol 17 (22) ◽  
pp. 8549
Author(s):  
Fu-Hsuan Kuo ◽  
Chia-Yi Lee ◽  
Ju-Pi Li ◽  
Jui-Fu Chung ◽  
Yu-Hsun Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Chronic Kidney Disease ◽  
Risk Factor ◽  
Cohort Study ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Hazard Ratio ◽  
Study Group ◽  
Artery Disease

We aim to evaluate the development of peripheral occlusive artery disease (PAOD) in patients with migraine by using the National Health Insurance Research Database in Taiwan. A retrospective cohort study was conducted and individuals with diagnostic codes of migraine were enrolled in the study group after excluding those diagnosed with PAOD before the index date. Each subject with migraine was propensity-score matched to another non-migraine patient and the latter served as the control group. A total of 37,288 patients were finally enrolled in the groups. The primary outcome was set as the development of PAOD between the two groups while multiple possible risk factors, including demographic data and comorbidities, were analyzed via the Cox proportional hazards regression. There were 885 and 530 PAOD events in the study and control groups, and the study group had a significantly higher adjusted hazard ratio (1.65, 95% confidential interval: 1.48–1.84, p < 0.001), and the cumulative incidence also revealed a correlation between migraine and PAOD. Other potential risk factors related to the existence of PAOD include age, hypertension, chronic kidney disease, diabetes mellitus, coronary artery disease, stroke, and asthma. For individuals without certain systemic diseases including hypertension, chronic liver disease, chronic kidney disease, coronary artery disease, stroke, asthma, or heart failure, the hazard ratio of subsequent PAOD was significantly higher in the migraine patients than that in the non-migraine individuals (all p < 0.001). In conclusion, the presence of migraine is a significant risk factor for the development of subsequent PAOD.

scholarly journals Functional Gly297Ser Variant of the Physiological Dysglycemic Peptide Pancreastatin is a Novel Risk Factor for Cardiometabolic Disorders

2021 ◽  
Author(s):  
Prasanna K. R. Allu ◽  
Malapaka Kiranmayi ◽  
Sromona D. Mukherjee ◽  
Venkat R. Chirasani ◽  
Richa Garg ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Human Populations ◽  
Wild Type ◽  
Cardiometabolic Disorders ◽  
Artery Disease ◽  
Variant Peptide

Pancreastatin (PST), a chromogranin A (CHGA)-derived potent physiological dysglycemic peptide, regulates glucose/insulin homeostasis. We have identified a non-synonymous functional PST variant (p.Gly297Ser; rs9658664) that occurs in a large section of human populations. Association analysis of this single nucleotide polymorphism with cardiovascular/metabolic diseases states in Indian populations (n≈4300 subjects) displays elevated plasma glucose, glycosylated hemoglobin, diastolic blood pressure and catecholamines in Gly/Ser subjects as compared to wild-type individuals (Gly/Gly). Consistently, the 297Ser allele confers an increased risk (~1.3-1.6-fold) for type-2 diabetes/hypertension/coronary artery disease/metabolic syndrome. In corroboration, the variant peptide (PST-297S) displays gain-of-potency in several cellular events relevant for cardiometabolic disorders (<i>e.g.</i>, increased expression of gluconeogenic genes, increased catecholamine secretion, greater inhibition of insulin-stimulated glucose-uptake) than the wild-type peptide (PST-WT). Computational docking analysis and molecular dynamics simulations show higher affinity binding of PST-297S peptide with glucose-regulated protein 78 (GRP78) and insulin receptor (IR) than PST-WT, providing a mechanistic basis for the enhanced activity of the variant peptide. <i>In vitro</i> binding assays validate these <i>in silico</i> predictions of PST peptides binding to GRP78 and IR. In conclusion, the PST 297Ser allele influences cardiovascular/metabolic phenotypes and emerges as a novel risk factor for type-2 diabetes/hypertension/coronary artery disease in human populations.

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