Antioxidant Effect of Alpha-Lipoic Acid against Ethanol-Induced Gastric Mucosal Erosion in Rats

Pharmacology ◽  
2007 ◽  
Vol 81 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Özer Şehirli ◽  
Elif Tatlıdede ◽  
Meral Yüksel ◽  
Can Erzik ◽  
Sule Çetinel ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Antioxidant Effect ◽  
Alpha Lipoic Acid ◽  
Mucosal Erosion

scholarly journals Alpha-Lipoic Acid Alleviates High-Glucose Suppressed Osteogenic Differentiation of MC3T3-E1 Cells via Antioxidant Effect and PI3K/Akt Signaling Pathway

2017 ◽  
Vol 42 (5) ◽  
pp. 1897-1906 ◽  
Author(s):  
Kai Dong ◽  
Pengjie Hao ◽  
Sheng Xu ◽  
Shutai Liu ◽  
Wenjuan Zhou ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Osteogenic Differentiation ◽  
Lipoic Acid ◽  
High Glucose ◽  
Osteoblastic Differentiation ◽  
Antioxidant Effect ◽  
Akt Pathway ◽  
Alpha Lipoic Acid ◽  
Western Blots ◽  
Alizarin Red

Background/Aims: Patients with diabetes mellitus have a higher risk of dental implant failure. One major cause is high-glucose induced oxidative stress. Alpha-lipoic acid (ALA), a naturally occurring compound and dietary supplement, has been established as a potent antioxidant that is a strong scavenger of free radicals. However, few studies have yet investigated the effect of ALA on osteogenic differentiation of osteoblasts cultured with high glucose medium. The aim of this study is to investigate the effects of ALA on the osteoblastic differentiation in MC3T3-E1 cells under high glucose condition. Methods: MC3T3-E1 cells were divided into 4 groups including normal glucose (5.5 mM) group (control), high glucose (25.5 mM) group, high glucose + 0.1 mM ALA group, and high glucose + 0.2 mM ALA group. The proliferation, osteogenic differentiation and mineralization of cells were evaluated by MTT assay, alkaline phosphatase (ALP) activity assay, alizarin red staining and real time-polymerase chain reaction. High-glucose induced oxidative damage was also assessed by the production of reactive oxygen species (ROS) and superoxide dismutase (SOD). Western blots were performed to examine the role of PI3K/Akt pathway. Results: The proliferation, osteogenic differentiation and mineralization of MC3T3-E1 cells were significantly decreased by the ROS induced by high-glucose. All observed oxidative damage and osteogenic dysfunction induced were inhibited by ALA. Moreover, the PI3K/Akt pathway was activated by ALA. Conclusions: We demonstrate that ALA may attenuate high-glucose mediated MC3T3-E1 cells dysfunction through antioxidant effect and modulation of PI3K/Akt pathway.

Effect of alpha-lipoic acid on boar spermatozoa quality during freezing–thawing

Zygote ◽  
2015 ◽  
Vol 24 (2) ◽  
pp. 259-265 ◽  
Author(s):  
Tao Shen ◽  
Zhong-Liang Jiang ◽  
Cong-Jun Li ◽  
Xiao-Chen Hu ◽  
Qing-Wang Li
Keyword(s):  
Lipoic Acid ◽  
Artificial Insemination ◽  
Antioxidant Effect ◽  
Control Group ◽  
Antioxidant Enzyme Activities ◽  
Alpha Lipoic Acid ◽  
Glutamic Oxaloacetic Transaminase ◽  
Boar Semen ◽  
Endogenous Antioxidant ◽  
Boar Spermatozoa

SummaryAlpha-lipoic acid (ALA) is known to be a natural antioxidant. The aim of the present study was to evaluate the cryoprotective effect of ALA on the motility of boar spermatozoa and its antioxidant effect on boar spermatozoa during freezing–thawing. Different concentrations (2.0, 4.0, 6.0, 8.0 or 10.0 mg/ml) of ALA were added to the extender used to freeze boar semen, and the effects on the quality and endogenous antioxidant enzyme activities of frozen–thawed spermatozoa were assessed. The results indicated that the addition of ALA to the extender resulted in a higher percentage of motile spermatozoa post-thaw (P < 0.05). The activities of superoxide dismutase, lactate dehydrogenase, glutamic-oxaloacetic transaminase and catalase improved after adding ALA to the extender (P < 0.05). Artificial insemination results showed that pregnancy rate and litter size were significantly higher at 6.0 mg/ml in the ALA group than in the control group (P < 0.05). In conclusion, ALA conferred a cryoprotective capacity to the extender used for boar semen during the process of freezing–thawing, and the optimal concentration of ALA for the frozen extender was 6.0 mg/ml.

Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone

2017 ◽  
Vol 219 ◽  
pp. 49-57 ◽  
Author(s):  
Tatiana de Queiroz Oliveira ◽  
Caren Nádia Soares de Sousa ◽  
Germana Silva Vasconcelos ◽  
Luciene Costa de Sousa ◽  
Anneheydi Araújo de Oliveira ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Antioxidant Effect ◽  
Alpha Lipoic Acid

Effect of the alpha-lipoic acid on apoptosis in HIT-T15 cells induced by high glucose

2010 ◽  
Vol 34 (8) ◽  
pp. S14-S14
Author(s):  
Yi Yang ◽  
Wei‑Ping Wang ◽  
Yi‑Nan Liu ◽  
Ting Guo ◽  
Ping Chen ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
High Glucose ◽  
Alpha Lipoic Acid

Evaluation of dissolution profiles of alpha lipoic acid soft gelatin capsules and tablets

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
A Uzunovic ◽  
S Hadzidedic ◽  
A Elezovic ◽  
S Pilipovic ◽  
A Sapcanin
Keyword(s):  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Gelatin Capsules ◽  
Soft Gelatin Capsules

Secunder prevention with alpha-lipoic acid and vitamin E in porphyria cutanea tarda patients

2008 ◽  
Vol 46 (05) ◽  
Author(s):  
E Székely ◽  
K Szentmihályi ◽  
M Bor ◽  
Á Pusztai ◽  
T Kurucz ◽  
...  
Keyword(s):  
Vitamin E ◽  
Lipoic Acid ◽  
Porphyria Cutanea Tarda ◽  
Alpha Lipoic Acid

Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells

Diabetes ◽  
1997 ◽  
Vol 46 (9) ◽  
pp. 1481-1490 ◽  
Author(s):  
A. Bierhaus ◽  
S. Chevion ◽  
M. Chevion ◽  
M. Hofmann ◽  
P. Quehenberger ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Cultured Endothelial Cells ◽  
Nf Kappab
Sign in / Sign up

Export Citation Format

Share Document