Selection of Patients for Clinical Trials

1987 ◽  
Vol 6 (1-2) ◽  
pp. 34-39
Author(s):  
Alastair Compston
Keyword(s):  
Clinical Trials ◽  
Selection Of Patients ◽  
Selection Of

Selection of Patients for the Initial Clinical Trials of Kidney Xenotransplantation

2020 ◽  
pp. 209-220
Author(s):  
David K. C. Cooper ◽  
Abhijit Jagdale ◽  
Roslynn B. Mannon ◽  
Vineeta Kumar ◽  
Robert Gaston ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Selection Of Patients ◽  
Selection Of

scholarly journals Management of Brain and Leptomeningeal Metastases from Breast Cancer

2020 ◽  
Vol 21 (22) ◽  
pp. 8534
Author(s):  
Alessia Pellerino ◽  
Valeria Internò ◽  
Francesca Mo ◽  
Federica Franchino ◽  
Riccardo Soffietti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
Systemic Therapy ◽  
Chemotherapeutic Agents ◽  
Leptomeningeal Metastases ◽  
Targeted Agents ◽  
Molecular Subgroups ◽  
Extracranial Disease ◽  
Selection Of Patients ◽  
Selection Of

The management of breast cancer (BC) has rapidly evolved in the last 20 years. The improvement of systemic therapy allows a remarkable control of extracranial disease. However, brain (BM) and leptomeningeal metastases (LM) are frequent complications of advanced BC and represent a challenging issue for clinicians. Some prognostic scales designed for metastatic BC have been employed to select fit patients for adequate therapy and enrollment in clinical trials. Different systemic drugs, such as targeted therapies with either monoclonal antibodies or small tyrosine kinase molecules, or modified chemotherapeutic agents are under investigation. Major aims are to improve the penetration of active drugs through the blood–brain barrier (BBB) or brain–tumor barrier (BTB), and establish the best sequence and timing of radiotherapy and systemic therapy to avoid neurocognitive impairment. Moreover, pharmacologic prevention is a new concept driven by the efficacy of targeted agents on macrometastases from specific molecular subgroups. This review aims to provide an overview of the clinical and molecular factors involved in the selection of patients for local and/or systemic therapy, as well as the results of clinical trials on advanced BC. Moreover, insight on promising therapeutic options and potential directions of future therapeutic targets against BBB and microenvironment are discussed.

Pragmatic Versus Explanatory Trials

1989 ◽  
Vol 5 (3) ◽  
pp. 333-339 ◽  
Author(s):  
Kenneth D. MacRae
Keyword(s):  
Clinical Trials ◽  
Alternative Treatment ◽  
Treatment Comparison ◽  
Explanatory Trials ◽  
Treatment Policies ◽  
Selection Of Patients ◽  
Selection Of

This article considers the distinction between “explanatory” and “pragmatic” aims in clinical trials—the distinction between testing a biological hypothesis and providing evidence to permit a choice between alternative treatment policies. The choice of treatments to compare, the selection of patients for the trial, the study size, and how the treatment comparison should be made are among the matters discussed. In general, where explanatory and pragmatic aims conflict, the pragmatic aim will often take priority.

scholarly journals An Inflammation Based Score Can Optimize the Selection of Patients with Advanced Cancer Considered for Early Phase Clinical Trials

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e83279 ◽  
Author(s):  
David J. Pinato ◽  
Chara Stavraka ◽  
Michael J. Flynn ◽  
Martin D. Forster ◽  
Séan M. O'Cathail ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Advanced Cancer ◽  
Early Phase ◽  
Early Phase Clinical Trials ◽  
Selection Of Patients ◽  
Selection Of

Selection of Patients in Ongoing Clinical Trials on Lung Cancer

Lung ◽  
2016 ◽  
Vol 194 (6) ◽  
pp. 967-974 ◽  
Author(s):  
Karlijn J.G. Schulkes ◽  
Cindy Nguyen ◽  
Frederiek van den Bos ◽  
Leontine J.R. van Elden ◽  
Marije E. Hamaker
Keyword(s):  
Lung Cancer ◽  
Clinical Trials ◽  
Selection Of Patients ◽  
Selection Of

Selection of Patients for Clinical Trials

BMJ ◽  
1973 ◽  
Vol 4 (5888) ◽  
pp. 358-358
Author(s):  
P. Tyrer
Keyword(s):  
Clinical Trials ◽  
Selection Of Patients ◽  
Selection Of

scholarly journals Selection of Patients for Initial Clinical Trials of Solid Organ Xenotransplantation

2017 ◽  
Vol 101 (7) ◽  
pp. 1551-1558 ◽  
Author(s):  
David K.C. Cooper ◽  
Martin Wijkstrom ◽  
Sundaram Hariharan ◽  
Joshua L. Chan ◽  
Avneesh Singh ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Solid Organ ◽  
Selection Of Patients ◽  
Selection Of
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