Viral Vector-Mediated 12/15-Lipoxygenase Overexpression in Vascular Smooth Muscle Cells Enhances Inflammatory Gene Expression and Migration

2007 ◽  
Vol 45 (2) ◽  
pp. 132-142 ◽  
Author(s):  
Roopashree S. Dwarakanath ◽  
Saurabh Sahar ◽  
Linda Lanting ◽  
Nanping Wang ◽  
Michael B. Stemerman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Viral Vector ◽  
Muscle Cells ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene ◽  
And Migration

scholarly journals Effect of PGC-1αon Proliferation, Migration, and Transdifferentiation of Rat Vascular Smooth Muscle Cells Induced by High Glucose

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Xiaoqiang Qi ◽  
Yujing Zhang ◽  
Jing Li ◽  
Dongxia Hou ◽  
Yang Xiang
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
High Glucose ◽  
Muscle Cells ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene

We assessed the role of PGC-1α (PPARγ coactivator-1 alpha) in glucose-induced proliferation, migration, and inflammatory gene expression of vascular smooth muscle cells (VSMCs). We carried out phagocytosis studies to assess the role of PGC-1α in transdifferentiation of VSMCs by flow cytometry. We found that high glucose stimulated proliferation, migration and inflammatory gene expression of VSMCs, but overexpression of PGC-1α attenuated the effects of glucose. In addition, overexpression of PGC-1α decreased mRNA and protein level of VSMCs-related genes, and induced macrophage-related gene expression, as well as phagocytosis of VSMCs. Therefore, PGC-1α inhibited glucose-induced proliferation, migration and inflammatory gene expression of VSMCs, which are key features in the pathology of atherosclerosis. More importantly, PGC-1α transdifferentiated VSMCs to a macrophage-like state. Such transdifferentiation possibly increased the portion of VSMCs-derived foam cells in the plaque and favored plaque stability.

Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells

10.1038/77521 ◽  
2000 ◽  
Vol 6 (7) ◽  
pp. 790-796 ◽  
Author(s):  
Friedemann J. Schaub ◽  
David K.M. Han ◽  
W. Conrad Liles ◽  
Lawrence D. Adams ◽  
Scott A. Coats ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene ◽  
Specific Program

scholarly journals Angiotensin II Enhances Interleukin-18 Mediated Inflammatory Gene Expression in Vascular Smooth Muscle Cells

2005 ◽  
Vol 96 (10) ◽  
pp. 1064-1071 ◽  
Author(s):  
Saurabh Sahar ◽  
Roopashree S. Dwarakanath ◽  
Marpadga A. Reddy ◽  
Linda Lanting ◽  
Ivan Todorov ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Interleukin 18 ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene
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