Neutrophil Chemotaxis, Phagocytosis, and Generation of Reactive Oxygen Species Show a Hierarchy of Responsiveness to Increasing Concentrations of N-Formyl-Met-Leu-Phe

Neurosignals ◽  
1995 ◽  
Vol 4 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Osamu Iizawa ◽  
Hirohiko Akamatsu ◽  
Yukie Niwa
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Neutrophil Chemotaxis

scholarly journals Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis

2010 ◽  
Vol 107 (8) ◽  
pp. 3546-3551 ◽  
Author(s):  
Hidenori Hattori ◽  
Kulandayan K. Subramanian ◽  
Jiro Sakai ◽  
Yonghui Jia ◽  
Yitang Li ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Small Molecule ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Neutrophil Chemotaxis ◽  
Small Molecule Screen

Inhibitory Effect of Gabexate Mesilate on Human Neutrophil Function

1994 ◽  
Vol 22 (5) ◽  
pp. 245-254 ◽  
Author(s):  
K Mikawa ◽  
H Akamatsu ◽  
N Maekawa ◽  
K Nishina ◽  
H Obara ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Reactive Oxygen ◽  
Neutrophil Function ◽  
Oxygen Species ◽  
Neutrophil Chemotaxis ◽  
Gabexate Mesilate

Neutrophils accumulated in the lung are thought to play a key role in the pathogenesis of adult respiratory distress syndrome and interstitial pneumonia following bone-marrow transplantation. The effects of gabexate mesilate on several aspects of human neutrophil function have been investigated. Gabexate mesilate significantly decreased both the generation of reactive oxygen species (O2−, H202, OH·) by neutrophils and neutrophil chemotaxis. In contrast, the drug did not affect the levels of reactive oxygen species generated by a cell-free reactive-oxygen-species generating system. Intracellular calcium concentrations in neutrophils stimulated by f-Met-Leu-Phe were decreased in the presence of gabexate mesilate. These data suggest that the reduction in reactive-oxygen-species production and neutrophil chemotaxis by gabexate mesilate may contribute to the effectiveness of the drug in adult respiratory distress syndrome and interstitial pneumonia after bone-marrow transplantation. The suppression of the increase in intracellular calcium concentration may at least be responsible for the inhibition of these neutrophil functions by gabexate mesilate.

scholarly journals Exopolysaccharides fromBurkholderia cenocepaciaInhibit Neutrophil Chemotaxis and Scavenge Reactive Oxygen Species

2005 ◽  
Vol 281 (5) ◽  
pp. 2526-2532 ◽  
Author(s):  
Johan Bylund ◽  
Lee-Anna Burgess ◽  
Paola Cescutti ◽  
Robert K. Ernst ◽  
David P. Speert
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Neutrophil Chemotaxis

scholarly journals Reactive oxygen species as signaling molecules in neutrophil chemotaxis

2010 ◽  
Vol 3 (3) ◽  
pp. 278-281 ◽  
Author(s):  
Hidenori Hattori ◽  
Kulandayan K. Subramanian ◽  
Jiro Sakai ◽  
Hongbo R. Luo
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Signaling Molecules ◽  
Oxygen Species ◽  
Neutrophil Chemotaxis
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