Heat Shock Response, Heat Shock Transcription Factor and Cell Aging

Neurosignals ◽  
1996 ◽  
Vol 5 (3) ◽  
pp. 180-191 ◽  
Author(s):  
Yoon-Kwang Lee ◽  
Dominador Manalo ◽  
Alice Y.-C. Liu
Keyword(s):  
Transcription Factor ◽  
Heat Shock ◽  
Heat Shock Response ◽  
Heat Shock Transcription Factor ◽  
Cell Aging ◽  
Shock Response

scholarly journals The Role of Heat Shock Transcription Factor 1 in the Genome-wide Regulation of the Mammalian Heat Shock Response

2004 ◽  
Vol 15 (3) ◽  
pp. 1254-1261 ◽  
Author(s):  
Nathan D. Trinklein ◽  
John I. Murray ◽  
Sara J. Hartman ◽  
David Botstein ◽  
Richard M. Myers
Keyword(s):  
Transcription Factor ◽  
Heat Shock ◽  
Heat Shock Response ◽  
Mammalian Cells ◽  
Transcriptional Response ◽  
Heat Shock Transcription Factor ◽  
Genome Wide ◽  
Shock Response ◽  
Inducible Genes ◽  
Transcription Factor 1

Previous work has implicated heat shock transcription factor 1 (HSF1) as the primary transcription factor responsible for the transcriptional response to heat stress in mammalian cells. We characterized the heat shock response of mammalian cells by measuring changes in transcript levels and assaying binding of HSF1 to promoter regions for candidate heat shock genes chosen by a combination of genome-wide computational and experimental methods. We found that many heat-inducible genes have HSF1 binding sites (heat shock elements, HSEs) in their promoters that are bound by HSF1. Surprisingly, for 24 heat-inducible genes, we detected no HSEs and no HSF1 binding. Furthermore, of 182 promoters with likely HSE sequences, we detected HSF1 binding at only 94 of these promoters. Also unexpectedly, we found 48 genes with HSEs in their promoters that are bound by HSF1 but that nevertheless did not show induction after heat shock in the cell types we examined. We also studied the transcriptional response to heat shock in fibroblasts from mice lacking the HSF1 gene. We found 36 genes in these cells that are induced by heat as well as they are in wild-type cells. These results provide evidence that HSF1 does not regulate the induction of every transcript that accumulates after heat shock, and our results suggest that an independent posttranscriptional mechanism regulates the accumulation of a significant number of transcripts.

scholarly journals A model for handling cell stress

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Laura Le Breton ◽  
Matthias P Mayer
Keyword(s):  
Transcription Factor ◽  
Heat Shock ◽  
Heat Shock Response ◽  
Cell Stress ◽  
Heat Shock Transcription Factor ◽  
Chaperone Protein ◽  
Shock Response

The heat shock response in yeast is regulated by the interaction between a chaperone protein and a heat shock transcription factor, and fine-tuned by phosphorylation.

scholarly journals The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response

2018 ◽  
Vol 293 (49) ◽  
pp. 18965-18976 ◽  
Author(s):  
S. Mohammad Lellahi ◽  
Ingrid Arctander Rosenlund ◽  
Annica Hedberg ◽  
Liv Torill Kiær ◽  
Ingvild Mikkola ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heat Shock ◽  
Heat Shock Response ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Shock Response

In vivo heat-shock response in the brain: signalling pathway and transcription factor activation

2003 ◽  
Vol 119 (1) ◽  
pp. 90-99 ◽  
Author(s):  
Paola Maroni ◽  
Paola Bendinelli ◽  
Laura Tiberio ◽  
Francesca Rovetta ◽  
Roberta Piccoletti ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heat Shock ◽  
Heat Shock Response ◽  
Signalling Pathway ◽  
Transcription Factor Activation ◽  
Shock Response ◽  
The Brain

HSF Transcription Factor Family, Heat Shock Response, and Protein Intrinsic Disorder

2012 ◽  
Vol 13 (1) ◽  
pp. 86-103 ◽  
Author(s):  
Sandy D. Westerheide ◽  
Rachel Raynes ◽  
Chase Powell ◽  
Bin Xue ◽  
Vladimir N. Uversky
Keyword(s):  
Transcription Factor ◽  
Heat Shock ◽  
Heat Shock Response ◽  
Intrinsic Disorder ◽  
Transcription Factor Family ◽  
Shock Response ◽  
Protein Intrinsic Disorder

scholarly journals New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival

2017 ◽  
Vol 45 (10) ◽  
pp. 5797-5817 ◽  
Author(s):  
Nuria Vilaboa ◽  
Alba Boré ◽  
Francisco Martin-Saavedra ◽  
Melanie Bayford ◽  
Natalie Winfield ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heat Shock ◽  
Tumor Cell ◽  
Cell Survival ◽  
Heat Shock Response ◽  
Shock Response ◽  
Tumor Cell Survival ◽  
Human Transcription Factor

scholarly journals Sis1 delivers the State of the Union

2020 ◽  
Vol 220 (1) ◽  
Author(s):  
Danish Khan ◽  
Onn Brandman
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Heat Shock ◽  
Heat Shock Response ◽  
The State ◽  
Gene Expression Program ◽  
State Of The Union ◽  
Shock Response ◽  
Expression Program

The heat shock response (HSR) is a gene expression program that protects cells from heat and proteotoxic stressors. In this issue, Feder et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202005165) show that subcellular relocalization of the cochaperone Sis1 drives the HSR by de-suppressing the transcription factor Hsf1.

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