Amyotrophic Lateral Sclerosis in South-East England: A Population-Based Study

2007 ◽  
Vol 29 (1-2) ◽  
pp. 44-48 ◽  
Author(s):  
K. Abhinav ◽  
B. Stanton ◽  
C. Johnston ◽  
J. Hardstaff ◽  
R.W. Orrell ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Population Based ◽  
Population Based Study ◽  
South East England ◽  
Lateral Sclerosis

scholarly journals Amyotrophic lateral sclerosis: a comparison of two staging systems in a population-based study

2016 ◽  
Vol 23 (9) ◽  
pp. 1426-1432 ◽  
Author(s):  
D. Ferraro ◽  
D. Consonni ◽  
N. Fini ◽  
A. Fasano ◽  
C. Del Giovane ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Population Based ◽  
Population Based Study ◽  
Staging Systems ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis is not linked to multiple sclerosis in a population based study

2013 ◽  
Vol 84 (8) ◽  
pp. 940-941 ◽  
Author(s):  
P. T. C. van Doormaal ◽  
A. Gallo ◽  
W. van Rheenen ◽  
J. H. Veldink ◽  
M. A. van Es ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Amyotrophic Lateral Sclerosis ◽  
Population Based ◽  
Population Based Study ◽  
Lateral Sclerosis

Prognostic value of weight loss in patients with amyotrophic lateral sclerosis: a population-based study

2020 ◽  
Vol 91 (8) ◽  
pp. 867-875 ◽  
Author(s):  
Mark R Janse van Mantgem ◽  
Ruben P A van Eijk ◽  
Hannelore K van der Burgh ◽  
Harold H G Tan ◽  
Henk-Jan Westeneng ◽  
...  
Keyword(s):  
Weight Loss ◽  
Amyotrophic Lateral Sclerosis ◽  
Body Weight ◽  
Prognostic Value ◽  
Population Based ◽  
Data Set ◽  
Population Based Study ◽  
Risk Of Death ◽  
Lateral Sclerosis

ObjectiveTo determine the prevalence and prognostic value of weight loss (WL) prior to diagnosis in patients with amyotrophic lateral sclerosis (ALS).MethodsWe enrolled patients diagnosed with ALS between 2010 and 2018 in a population-based setting. At diagnosis, detailed information was obtained regarding the patient’s disease characteristics, anthropological changes, ALS-related genotypes and cognitive functioning. Complete survival data were obtained. Cox proportional hazard models were used to assess the association between WL and the risk of death during follow-up.ResultsThe data set comprised 2420 patients of whom 67.5% reported WL at diagnosis. WL occurred in 71.8% of the bulbar-onset and in 64.2% of the spinal-onset patients; the mean loss of body weight was 6.9% (95% CI 6.8 to 6.9) and 5.5% (95% CI 5.5 to 5.6), respectively (p<0.001). WL occurred in 35.1% of the patients without any symptom of dysphagia. WL is a strong independent predictor of survival, with a dose response relationship between the amount of WL and the risk of death: the risk of death during follow-up increased by 23% for every 10% increase in WL relative to body weight (HR 1.23, 95% CI 1.13 to 1.51, p<0.001).ConclusionsThis population-based study shows that two-thirds of the patients with ALS have WL at diagnosis, which also occurs independent of dysphagia, and is related to survival. Our results suggest that WL is a multifactorial process that may differ from patient to patient. Gaining further insight in its underlying factors could prove essential for future therapeutic measures.

scholarly journals Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark

2019 ◽  
pp. oemed-2018-105469 ◽  
Author(s):  
Aisha S Dickerson ◽  
Johnni Hansen ◽  
Aaron J Specht ◽  
Ole Gredal ◽  
Marc G Weisskopf
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Conditional Logistic Regression ◽  
Population Based ◽  
Population Based Study ◽  
Employment History ◽  
National Patient Registry ◽  
Increased Risk ◽  
National Patient ◽  
Pb Exposure ◽  
Lateral Sclerosis

ObjectivesPrevious research has indicated links between lead (Pb) exposure and increased risk of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In this study, we evaluated the association between occupational Pb exposures and ALS.MethodsALS cases were ascertained through the Danish National Patient Registry from 1982 to 2013 and age and sex-matched to 100 controls. Using complete employment history since 1964 from the Danish Pension Fund, cumulative Pb exposure was estimated for each subject via a Danish job exposure matrix. Associations were evaluated using conditional logistic regression analyses and stratified by sex.ResultsFor men with >50% probability of exposure, there was an increase in odds of ALS for exposures in the 60th percentile or higher during any time 5 years prior to diagnosis (aOR: 1.35; 95% CI 1.04 to 1.76) and 10 years prior to diagnosis (aOR: 1.33; 95% CI 1.03 to 1.72). No significant associations were observed in women, and there were no linear trends seen for Pb exposures for either sex.ConclusionsOur study indicates an association between consistently higher occupational Pb exposures and ALS. These findings support those of previously reported associations between ALS and specific occupations that commonly experience Pb exposure.

Incidence and Prevalence of Amyotrophic Lateral Sclerosis in Uruguay: A Population-Based Study

2008 ◽  
Vol 30 (2) ◽  
pp. 105-111 ◽  
Author(s):  
M.C. V&aacute;zquez ◽  
C. Ketzoi&aacute;n ◽  
C. Legnani ◽  
I. Rega ◽  
N. S&aacute;nchez ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Population Based ◽  
Population Based Study ◽  
Lateral Sclerosis

scholarly journals Common polymorphisms of chemokine (C-X3-C motif) receptor 1 gene modify amyotrophic lateral sclerosis outcome: A population-based study

2017 ◽  
Vol 57 (2) ◽  
pp. 212-216 ◽  
Author(s):  
Andrea Calvo ◽  
Cristina Moglia ◽  
Antonio Canosa ◽  
Stefania Cammarosano ◽  
Antonio Ilardi ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Population Based ◽  
Population Based Study ◽  
Lateral Sclerosis

Epidemiology of amyotrophic lateral sclerosis in Emilia Romagna Region (Italy): A population based study

2014 ◽  
Vol 15 (3-4) ◽  
pp. 262-268 ◽  
Author(s):  
Jessica Mandrioli ◽  
Sara Biguzzi ◽  
Carlo Guidi ◽  
Elisabetta Venturini ◽  
Elisabetta Sette ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Population Based ◽  
Population Based Study ◽  
Emilia Romagna Region ◽  
Lateral Sclerosis

Tracheostomy in amyotrophic lateral sclerosis: a 10-year population-based study in Italy

2010 ◽  
Vol 81 (10) ◽  
pp. 1141-1143 ◽  
Author(s):  
A. Chio ◽  
A. Calvo ◽  
P. Ghiglione ◽  
L. Mazzini ◽  
R. Mutani ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Population Based ◽  
Population Based Study ◽  
Lateral Sclerosis
Sign in / Sign up

Export Citation Format

Share Document