scholarly journals cDNA Microarray Analysis of Adaptive Changes after Renal Ablation in a Sclerosis-Resistant Mouse Strain

2007 ◽  
Vol 30 (6) ◽  
pp. 377-387 ◽  
Author(s):  
Brigitta Rumberger ◽  
Oliver Vonend ◽  
Clemens Kreutz ◽  
Jochen Wilpert ◽  
Johannes Donauer ◽  
...  
Keyword(s):  
Microarray Analysis ◽  
Cdna Microarray ◽  
Mouse Strain ◽  
Cdna Microarray Analysis ◽  
Resistant Mouse ◽  
Adaptive Changes ◽  
Renal Ablation ◽  
Resistant Mouse Strain

cDNA microarray analysis of developing grape (Vitis vinifera cv. Shiraz) berry skin

2004 ◽  
Vol 5 (1) ◽  
pp. 40-58 ◽  
Author(s):  
Daniel L. E. Waters ◽  
Timothy A. Holton ◽  
Effie M. Ablett ◽  
L. Slade Lee ◽  
Robert J. Henry
Keyword(s):  
Vitis Vinifera ◽  
Microarray Analysis ◽  
Cdna Microarray ◽  
Cdna Microarray Analysis ◽  
Berry Skin

scholarly journals Mouse cDNA microarray analysis uncovers Slug targets in mouse embryonic fibroblasts

Genomics ◽  
2006 ◽  
Vol 87 (1) ◽  
pp. 113-118 ◽  
Author(s):  
Camino Bermejo-Rodríguez ◽  
María Pérez-Caro ◽  
Pedro Antonio Pérez-Mancera ◽  
Margarita Sánchez-Beato ◽  
Miguel A. Piris ◽  
...  
Keyword(s):  
Microarray Analysis ◽  
Cdna Microarray ◽  
Cdna Microarray Analysis ◽  
Mouse Embryonic Fibroblasts ◽  
Embryonic Fibroblasts ◽  
Mouse Cdna

Potential for functional redundancy in EGF and TGFα signaling in desmoid cells: a cDNA microarray analysis

2009 ◽  
Vol 28 (1) ◽  
pp. 10-23 ◽  
Author(s):  
Sylvia H. Trang ◽  
David E. Joyner ◽  
Timothy A. Damron ◽  
Albert J. Aboulafia ◽  
R. Lor Randall
Keyword(s):  
Microarray Analysis ◽  
Cdna Microarray ◽  
Functional Redundancy ◽  
Cdna Microarray Analysis

scholarly journals Tumor-Stroma Crosstalk Enhances REG3A Expressions that Drive the Progression of Hepatocellular Carcinoma

2020 ◽  
Vol 21 (2) ◽  
pp. 472 ◽  
Author(s):  
Yuri Cho ◽  
Min Ji Park ◽  
Koeun Kim ◽  
Jae-Young Park ◽  
Jihye Kim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microarray Analysis ◽  
Cdna Microarray ◽  
Tumor Stroma ◽  
Mrna Levels ◽  
Dependent Manner ◽  
Cdna Microarray Analysis ◽  
Hcc Cells

Abstract: Background: Crosstalk between tumors and their microenvironment plays a crucial role in the progression of hepatocellular carcinoma (HCC). However, there is little existing information about the key signaling molecule that modulates tumor-stroma crosstalk. Methods: Complementary DNA (cDNA) microarray analysis was performed to identify the key molecule in tumor-stroma crosstalk. Subcutaneous xenograft in vivo murine model, immunoblotting, immunofluorescence, and real-time polymerase chain reaction using HCC cells and tissues were performed. Results: The key molecule, regenerating gene protein-3A (REG3A), was most significantly enhanced when coculturing HCC cells and activated human hepatic stellate cells (HSCs) (+8.2 log) compared with monoculturing HCC cells using cDNA microarray analysis. Downregulation of REG3A using small interfering RNA significantly decreased the proliferation of HSC-cocultured HCC cells in vitro and in vivo, and enhanced deoxycholic acid-induced HCC cell apoptosis. Crosstalk-induced REG3A upregulation was modulated by platelet-derived growth factor ββ (PDGF-ββ) in p42/44-dependent manner. REG3A mRNA levels in human HCC tissues were upregulated 1.8-fold compared with non-tumor tissues and positively correlated with PDGF-ββ levels. Conclusions: REG3A/p42/44 pathway/PDGF-ββ signaling plays a significant role in hepatocarcinogenesis via tumor-stroma crosstalk. Targeting REG3A is a potential novel therapeutic target for the management of HCCs by inhibiting crosstalk between HCC cells and HSCs.

scholarly journals cDNA microarray analysis using both gene expression ratios and intensities

10.1038/87032 ◽  
2001 ◽  
Vol 27 (S4) ◽  
pp. 46-47
Author(s):  
Yidong Chen ◽  
Hongen Zhang ◽  
Sujatha Panavally ◽  
Edward Dougherty ◽  
Michael Bittner ◽  
...  
Keyword(s):  
Gene Expression ◽  
Microarray Analysis ◽  
Cdna Microarray ◽  
Cdna Microarray Analysis
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