Interferon-α Influences Tryptophan Metabolism without Inducing Psychiatric Side Effects

2007 ◽  
Vol 55 (3-4) ◽  
pp. 225-231 ◽  
Author(s):  
Marjolein Bannink ◽  
Durk Fekkes ◽  
Arthur R. Van Gool ◽  
Wim H.J. Kruit ◽  
Stefan Sleijfer ◽  
...  
Keyword(s):  
Side Effects ◽  
Tryptophan Metabolism ◽  
Interferon Α ◽  
Psychiatric Side Effects

Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Azadeh Mesripour ◽  
Shahrzad Shahnooshi ◽  
Valiollah Hajhashemi
Keyword(s):  
Side Effects ◽  
Forced Swimming Test ◽  
Interferon Alfa ◽  
Interferon Α ◽  
High Dose ◽  
Antidepressant Effects ◽  
Immobility Time ◽  
Inflammatory Drugs ◽  
Swimming Test ◽  
Psychiatric Side Effects

AbstractBackgroundInterferon-α (IFNα) therapy causes psychiatric side effects, including depression that may result in poor compliance of therapy. It is important to find alternative therapies for the prevention of IFNα induced depression. Non-steroidal anti-inflammatory drugs (NSAIDs) have been useful in depressive disorder. Therefore the effects of celecoxib, ibuprofen, and indomethacin were evaluated following IFNα-induced depression in mice.MethodsMale albino mice weighing 26 ± 2 g were used. Depression was induced by IFNα (16 × 105 IU/kg, SC) for six consecutive days. Animals were first subject to the locomotor test, then the splash test and finally the forced swimming test (FST) on the 7th day. The NSAIDs were administered (IP) either one single dose before the test, or simultaneously with IFNα.Resultslocomotor activity was only impaired by ibuprofen high dose (75 mg/kg), thus it was not further evaluated. Following IFNα therapy depression-like behaviors were observed; significant changes during the splash test (grooming time 24 ± 7 sec vs. control 63 ± 7 sec), the FST (immobility time 166  ± 15 sec vs. control 128  ± 6 sec), and sucrose preference reduced to 64 ± 0.8%. The NSAIDs noticeably reduced the immobility time in FST, while grooming time was increased. Celecoxib and indomethacin single doses were effective while ibuprofen showed better antidepressant effects when it was administered along with IFNα.ConclusionsThe NSAIDs were able to prevent IFNα induced depression in mice. NSAIDs administration with IFNα does not interfere with clinical benefit effects of IFNα and they could also be useful to prevent IFNα psychiatric side effects, thus further clinical trials are suggested.

Interferon-α in Oncology Patients: Fewer Psychiatric Side Effects Than Anticipated

2008 ◽  
Vol 49 (1) ◽  
pp. 56-63 ◽  
Author(s):  
Marjolein Bannink ◽  
Wim H.J. Kruit ◽  
Arthur R. Van Gool ◽  
Stefan Sleijfer ◽  
Bronno van der Holt ◽  
...  
Keyword(s):  
Side Effects ◽  
Interferon Α ◽  
Oncology Patients ◽  
Psychiatric Side Effects

Burns in a suicide attempt related to psychiatric side effects of interferon

Burns ◽  
1998 ◽  
Vol 24 (6) ◽  
pp. 581-583 ◽  
Author(s):  
K. Fukunishi ◽  
H. Tanaka ◽  
J. Maruyama ◽  
H. Takahashi ◽  
H. Kitagishi ◽  
...  
Keyword(s):  
Side Effects ◽  
Suicide Attempt ◽  
Psychiatric Side Effects

P41 Psychiatric side effects of bilateral deep brain stimulation for movement disorders

Basal Ganglia ◽  
2011 ◽  
Vol 1 (2) ◽  
pp. 120-121
Author(s):  
M.O. Pinsker ◽  
F. Amtage ◽  
M. Berger ◽  
G. Nikkhah ◽  
L. Tebartz van Elst
Keyword(s):  
Deep Brain Stimulation ◽  
Side Effects ◽  
Brain Stimulation ◽  
Movement Disorders ◽  
Psychiatric Side Effects ◽  
Deep Brain

Psychiatric Side Effects

2019 ◽  
pp. 83-87
Author(s):  
Joshua Schimmel ◽  
Evren Burakgazi-Dalkilic ◽  
Hatice Burakgazi-Yilmaz
Keyword(s):  
Side Effects ◽  
Psychiatric Side Effects
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