Secondary Stroke Prevention with Antithrombotic Drugs: What to Do Next?

1997 ◽  
Vol 7 (6) ◽  
pp. 30-32 ◽  
Author(s):  
J. van Gijn ◽  
A. Algra
Keyword(s):  
Stroke Prevention ◽  
Secondary Stroke Prevention ◽  
Antithrombotic Drugs

Secondary Stroke Prevention with Antithrombotic Drugs

2010 ◽  
Vol 8 (1) ◽  
pp. 129-133 ◽  
Author(s):  
Els Lisette De Schryver ◽  
Ale Algra
Keyword(s):  
Stroke Prevention ◽  
Secondary Stroke Prevention ◽  
Antithrombotic Drugs

PCV42 Antiplatelet Treatment Patterns for Secondary Stroke Prevention in the United Kingdom

2021 ◽  
Vol 24 ◽  
pp. S74
Author(s):  
J. Jiang ◽  
D. Li ◽  
J. Horrow ◽  
H. Tamada ◽  
A. Kahl ◽  
...  
Keyword(s):  
United Kingdom ◽  
Stroke Prevention ◽  
Treatment Patterns ◽  
Secondary Stroke Prevention ◽  
Antiplatelet Treatment ◽  
The United Kingdom

A Program to Improve Secondary Stroke Prevention

2011 ◽  
Vol 43 (4) ◽  
pp. 199-204 ◽  
Author(s):  
Michelle M. Menard ◽  
Don B. Smith ◽  
Cristina Taormina
Keyword(s):  
Stroke Prevention ◽  
Secondary Stroke Prevention

scholarly journals The aptamer BT200 blocks von Willebrand factor and platelet function in blood of stroke patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Katarina D. Kovacevic ◽  
Stefan Greisenegger ◽  
Agnes Langer ◽  
Georg Gelbenegger ◽  
Nina Buchtele ◽  
...  
Keyword(s):  
Platelet Function ◽  
Von Willebrand Factor ◽  
Stroke Prevention ◽  
Adenosine Diphosphate ◽  
Target Range ◽  
Large Artery ◽  
Dependent Manner ◽  
Secondary Stroke Prevention ◽  
Von Willebrand ◽  
Willebrand Factor

AbstractThe effect of conventional anti-platelet agents is limited in secondary stroke prevention, and their effects are blunted under high shear stress in the presence of increased levels of circulating von Willebrand factor (VWF). VWF is critically involved in thrombus formation at sites of stenotic extracranial/intracranial arteries. A third generation anti-VWF aptamer (BT200) has been generated which could be useful for secondary stroke prevention. To characterize the effects of BT200 in blood of patients with large artery atherosclerosis stroke (LAA). Blood samples were obtained from 33 patients with acute stroke or transient ischemic attack to measure inhibition of VWF activity and VWF-dependent platelet function. Patients who received clopidogrel or dual antiplatelet therapy did not differ in VWF dependent platelet function tests from aspirin treated patients. Of 18 patients receiving clopidogrel with or without aspirin, only 3 had a prolonged collagen adenosine diphosphate closure time, and none of the patients had ristocetin induced aggregation in the target range. BT200 concentration-dependently reduced median VWF activity from 178 to < 3%, ristocetin induced platelet aggregation from 40U to < 10U and prolonged collagen adenosine diphosphate closure times from 93 s to > 300 s. Baseline VWF activity correlated (r = 0.86, p < 0.001) with concentrations needed to reduce VWF activity to < 20% of normal, indicating that BT200 acts in a target concentration-dependent manner. Together with a long half-life supporting once weekly administration, the safety and tolerability observed in an ongoing phase I trial, and the existence of a reversal agent, BT200 is an interesting drug candidate.

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