Transport Barriers in Transscleral Drug Delivery for Retinal Diseases

2007 ◽  
Vol 39 (5) ◽  
pp. 244-254 ◽  
Author(s):  
Stephanie H. Kim ◽  
Robert J. Lutz ◽  
Nam Sun Wang ◽  
Michael R. Robinson
Keyword(s):  
Drug Delivery ◽  
Retinal Diseases ◽  
Transscleral Drug Delivery ◽  
Transport Barriers

scholarly journals Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications

2010 ◽  
Vol 51 (11) ◽  
pp. 5403 ◽  
Author(s):  
Henry F. Edelhauser ◽  
Cheryl L. Rowe-Rendleman ◽  
Michael R. Robinson ◽  
Daniel G. Dawson ◽  
Gerald J. Chader ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Basic Research ◽  
Delivery Systems ◽  
Clinical Applications ◽  
Retinal Diseases ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

Effect of Benzalkonium Chloride on Transscleral Drug Delivery

2005 ◽  
Vol 46 (2) ◽  
pp. 703 ◽  
Author(s):  
Komei Okabe ◽  
Hideya Kimura ◽  
Junko Okabe ◽  
Aki Kato ◽  
Hideo Shimizu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Benzalkonium Chloride ◽  
Transscleral Drug Delivery

scholarly journals Topical Drug Delivery to the Posterior Segment of the Eye

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 134
Author(s):  
Marina Löscher ◽  
Chiara Seiz ◽  
José Hurst ◽  
Sven Schnichels
Keyword(s):  
Drug Delivery ◽  
Animal Models ◽  
Treatment Option ◽  
Topical Treatment ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
Posterior Segment ◽  
Retinal Diseases ◽  
Topical Drug Delivery ◽  
Ocular Pharmacokinetics

Topical drug delivery to the posterior segment of the eye is a very complex challenge. However, topical delivery is highly desired, to achieve an easy-to-use treatment option for retinal diseases. In this review, we focus on the drug characteristics that are relevant to succeed in this challenge. An overview on the ocular barriers that need to be overcome and some relevant animal models to study ocular pharmacokinetics are given. Furthermore, a summary of substances that were able to reach the posterior segment after eye drop application is provided, as well as an outline of investigated delivery systems to improve ocular drug delivery. Some promising results of substances delivered to the retina suggest that topical treatment of retinal diseases might be possible in the future, which warrants further research.

Evaluation of Clearance Mechanisms with Transscleral Drug Delivery

2010 ◽  
Vol 51 (10) ◽  
pp. 5205 ◽  
Author(s):  
Sung Jin Lee ◽  
Weiling He ◽  
Shaun B. Robinson ◽  
Michael R. Robinson ◽  
Karl G. Csaky ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transscleral Drug Delivery

In VitroSustained Human Transscleral Drug Delivery of Fluorescein-Labeled Dexamethasone and Methotrexate with Fibrin Sealant

2005 ◽  
Vol 30 (8) ◽  
pp. 653-660 ◽  
Author(s):  
Lars P. J. Cruysberg ◽  
Rudy M. M. A. Nuijts ◽  
Jake A. Gilbert ◽  
Dayle H. Geroski ◽  
Fred Hendrikse ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fibrin Sealant ◽  
Transscleral Drug Delivery
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