The Startle Reflex in Alcohol-Dependent Patients: Changes after Cognitive-Behavioral Therapy and Predictive Validity for Drinking Behavior

2007 ◽  
Vol 76 (6) ◽  
pp. 385-390 ◽  
Author(s):  
Sabine Loeber ◽  
Bernhard Croissant ◽  
Helmut Nakovics ◽  
Anke Zimmer ◽  
Alexander Georgi ◽  
...  
2004 ◽  
Vol 65 (10) ◽  
pp. 1406-1413 ◽  
Author(s):  
Hermann Wetzel ◽  
Armin Szegedi ◽  
Armin Scheurich ◽  
Bernd Lörch ◽  
Peter Singer ◽  
...  

2015 ◽  
Vol 21 (4) ◽  
pp. 195-203 ◽  
Author(s):  
Rosa Jurado-Barba ◽  
Gabriel Rubio Valladolid ◽  
Isabel Martínez-Gras ◽  
María José Alvarez-Alonso ◽  
Guillermo Ponce Alfaro ◽  
...  

Aims: Little is known about changes in the modulation of the startle reflex when patients go through an alcohol-dependence treatment in an outpatient facility. In the current study, the affective modulation of the cue-related startle reflex has been used to evaluate changes in the emotional processing of alcohol-related stimuli that occurred after a standard cognitive-behavioral intervention, and to assess the outcome of this intervention. We hypothesized a ‘normalization' of the startle inhibition for the alcohol-related cues during the period of treatment. We also assumed that higher startle inhibition at baseline elicited by alcohol cues would predict the relapse on alcohol consumption during treatment. Participants: A total of 98 alcohol-dependent subjects were included who fulfilled DSM-IV criteria for alcohol dependence. A control group of 72 subjects was selected to match demographic characteristics. Measurements: All patients received a standard cognitive-behavioral therapy once a week throughout the study period. Findings: Results show that the startle response differed significantly after 12 weeks of treatment for alcohol-related, neutral and aversive stimuli between alcohol-dependent patients and controls. Low startle responses at baseline to alcohol cues predicted relapse. Conclusions: These results may indicate that the startle reflex is referred to enduring and permanent processes of cue reactivity, and that the emotional processing of alcohol-associated cues assessed with the affect-modulated startle reflex is less altered by interventions attempting to influence explicit cognitions. Furthermore, lower values of the baseline startle reflex elicited by alcohol-associated stimuli were associated with higher probability of relapse on alcohol use.


2016 ◽  
Vol 30 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Fred Arne Thorberg ◽  
Ross McD. Young ◽  
Karen A. Sullivan ◽  
Michael Lyvers ◽  
Cameron P. Hurst ◽  
...  

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