Galanthamine Hydrobromide in a Long-Term Treatment of Alzheimer's Disease

1990 ◽  
Vol 1 (1) ◽  
pp. 46-51 ◽  
Author(s):  
T. Thomsen ◽  
U. Bickel ◽  
J.P Fischer ◽  
H. Kewitz
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Term Treatment ◽  
Long Term Treatment ◽  
Galanthamine Hydrobromide

scholarly journals Suppression of AMD-Like Pathology by Mitochondria-Targeted Antioxidant SkQ1 Is Associated with a Decrease in the Accumulation of Amyloid β and in mTOR Activity

Antioxidants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 177 ◽  
Author(s):  
Natalia A. Muraleva ◽  
Oyuna S. Kozhevnikova ◽  
Anzhela Z. Fursova ◽  
Nataliya G. Kolosova
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Developed Countries ◽  
Term Treatment ◽  
Age Related Macular Degeneration ◽  
Eye Health ◽  
Age Related ◽  
Long Term Treatment

Age-related macular degeneration (AMD) is a major cause of irreversible visual impairment and blindness in developed countries, and the molecular pathogenesis of AMD is poorly understood. Recent studies strongly indicate that amyloid β (Aβ) accumulation —found in the brain and a defining feature of Alzheimer’s disease—also forms in the retina in both Alzheimer’s disease and AMD. The reason why highly neurotoxic proteins of consistently aggregate in the aging retina, and to what extent they contribute to AMD, remains to be fully addressed. Nonetheless, the hypothesis that Aβ is a therapeutic target in AMD is debated. Here, we showed that long-term treatment with SkQ1 (250 nmol/[kg body weight] daily from the age of 1.5 to 22 months) suppressed the development of AMD-like pathology in senescence-accelerated OXYS rats by reducing the level of Aβ and suppressing the activity of mTOR in the retina. Inhibition of mTOR signaling activity, which plays key roles in aging and age-related diseases, can be considered a new mechanism of the prophylactic effect of SkQ1. It seems probable that dietary supplementation with mitochondria-targeted antioxidant SkQ1 can be a good prevention strategy to maintain eye health and possibly a treatment of AMD.

P1-354 Long-term treatment with galantamine in patients with Alzheimer's disease and Alzheimer's disease with cerebrovascular disease

2004 ◽  
Vol 25 ◽  
pp. S198-S199
Author(s):  
Howard Feldman ◽  
Bart Van Baelen ◽  
H. Robert Brashear ◽  
Susanne Schwalen ◽  
Shane Kavanagh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrovascular Disease ◽  
Term Treatment ◽  
Long Term Treatment

scholarly journals Long-term treatment with active Aβ immunotherapy with CAD106 in mild Alzheimer’s disease

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Martin R Farlow ◽  
Niels Andreasen ◽  
Marie-Emmanuelle Riviere ◽  
Igor Vostiar ◽  
Alessandra Vitaliti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Term Treatment ◽  
Long Term Treatment

569 Long-term treatment of Alzheimer's disease with idebenone

1996 ◽  
Vol 17 (4) ◽  
pp. S141-S142
Author(s):  
H. Gutzmann ◽  
H. Erzigkeit ◽  
D. Hadler
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Term Treatment ◽  
Long Term Treatment
Sign in / Sign up

Export Citation Format

Share Document