Temporal-Parietal Hypoperfusion with Single-Photon Emission Computerized Tomography in Conditions Other than Alzheimer's Disease

1990 ◽  
Vol 1 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Bruce L. Miller ◽  
Ismael Mena ◽  
James Daly ◽  
Robert J. Giombetti ◽  
Mark A. Goldberg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Computerized Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Single Photon Emission

scholarly journals Brain SPECT in dementia a clinical-scintigraphic correlation

1996 ◽  
Vol 54 (3) ◽  
pp. 375-383 ◽  
Author(s):  
Carlos A. Buchpiguel ◽  
Sandra C. Mathias ◽  
Liliam Y. Itaya ◽  
Nélio G. Barros ◽  
Luis A.P. Portela ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Computerized Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
High Specificity ◽  
Single Photon Emission ◽  
Diagnosis Of Dementia ◽  
Similar Accuracy

The aim of this study was to compare the accuracy of computed tomography (CT) and single photon emission computerized tomography (SPECT) in the diagnosis of dementia. Fifty-two patients with clinical diagnosis of dementia and 11 controls were studied. The scans were interpreted by one experienced neuroradiologist and one nuclear radiologist, both blinded to the clinical data. In the diagnosis of dementia, CT and SPECT showed equal sensitivity (82.7%) and statistically similar specificity (63.8 and 81.8%, respectively). The specificity of SPECT in diagnosing Alzheimer's disease (100%) was statistically superior to CT (69%). However, both methods showed similar sensitivity in detecting Alzheimer's disease. In conclusion, SPECT and CT showed similar accuracy in the diagnosis of dementia. The quite high specificity of SPECT in Alzheimer's disease may be useful for confirming that diagnosis, particularly for patients with presenile onset of the disease.

The pattern of function-related regional cerebral blood flow investigated by single photon emission tomography with99mTc-HMPAO in patients with presenile Alzheimer's disease and Korsakoff's psychosis

1989 ◽  
Vol 19 (4) ◽  
pp. 847-855 ◽  
Author(s):  
R. Hunter ◽  
R. McLuskie ◽  
D. Wyper ◽  
J. Patterson ◽  
J. E. Christie ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Tomography ◽  
Regional Cerebral Blood ◽  
Single Photon Emission ◽  
Cortical Areas ◽  
Photon Emission Tomography

SYNOPSISSingle photon emission tomography (SPET) with the lipophilic blood flow marker99mTc-hexamethyl propyleneamine oxime (99mTc-HMPAO) has been used to determine regional uptake of radiolabel into brain regions of patients with presenile Alzheimer's disease and Korsakoff's psychosis, and age-matched controls. Using occipital cortical uptake as reference area, the pattern of relative regional cerebral blood flow (rCBF) was determined in other cortical areas and basal ganglia. In Alzheimer's disease, reduction in rCBF occurred most strikingly in posterior temporal and parietal areas. By contrast, in Korsakoff's psychosis, posterior temporal rCBF was maintained, although there was a trend to reduced tracer uptake in other cortical areas. These impairments of flow were correlated with impairments of neuropsychological function. In Alzheimer's disease, left posterior temporal and left parietal regions in particular showed rCBF to be strongly correlated with most aspects of cognitive function. In Korsakoff's psychosis, however, impaired flow in frontal regions was correlated with impaired performance on tests of memory and orientation. The findings in Alzheimer's disease show quantitative parallels with those from studies using Positron Emission Tomography (PET), and extend our understanding of the relationship between cognition and regional brain function in dementia. The findings in Korsakoff's psychosis offer the first direct evidence linking frontal lobe dysfunction with the cognitive impairment seen in the disorder.

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