Senile Dementia of Lewy Body Type and Alzheimer Type Are Biochemically Distinct in Terms of Paired Helical Filaments and Hyperphosphorylated Tau Protein (Part 1 of 2)

1994 ◽  
Vol 5 (5) ◽  
pp. 215-221 ◽  
Author(s):  
C.R. Harrington ◽  
R.H. Perry ◽  
E.K. Perry ◽  
J. Hurt ◽  
I.G. McKeith ◽  
...  
Keyword(s):  
Tau Protein ◽  
Lewy Body ◽  
Senile Dementia ◽  
Paired Helical Filaments ◽  
Hyperphosphorylated Tau ◽  
Alzheimer Type ◽  
Body Type ◽  
Hyperphosphorylated Tau Protein ◽  
Protein Part

Abnormally Phosphorylated Tau Protein in Senile Dementia of Lewy Body Type and Alzheimer Disease

1995 ◽  
Vol 9 (4) ◽  
pp. 218-222 ◽  
Author(s):  
C. Strong ◽  
B. H. Anderton ◽  
R. H. Perry ◽  
E. K. Perry ◽  
P. G. Ince ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Tau Protein ◽  
Lewy Body ◽  
Senile Dementia ◽  
Phosphorylated Tau ◽  
Body Type ◽  
Phosphorylated Tau Protein

Abnormally Phosphorylated Tau Protein in Senile Dementia of Lewy Body Type and Alzheimer Disease

1995 ◽  
Vol 9 (4) ◽  
pp. 218-222
Author(s):  
C. Strong ◽  
B. H. Anderton ◽  
R. H. Perry ◽  
E. K. Perry ◽  
P. G. Ince ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Tau Protein ◽  
Lewy Body ◽  
Senile Dementia ◽  
Phosphorylated Tau ◽  
Body Type ◽  
Phosphorylated Tau Protein

scholarly journals Effects of resveratrol and morin on insoluble tau in tau transgenic mice

2018 ◽  
Vol 9 (1) ◽  
pp. 54-60 ◽  
Author(s):  
Kwun Chung Yu ◽  
Ping Kwan ◽  
Stanley K.K. Cheung ◽  
Amy Ho ◽  
Larry Baum
Keyword(s):  
Transgenic Mice ◽  
Motor Function ◽  
Tau Protein ◽  
Late Stage ◽  
Animal Studies ◽  
Paired Helical Filaments ◽  
Hyperphosphorylated Tau ◽  
Total Tau ◽  
Tau Aggregation ◽  
Do So

Abstract Tauopathies are neurodegenerative diseases, including Alzheimer’s disease (AD) and frontotemporal dementia (FTD), in which tau protein aggregates within neurons. An effective treatment is lacking and is urgently needed. We evaluated two structurally similar natural compounds, morin and resveratrol, for treating tauopathy in JNPL3 P301L mutant human tau overexpressing mice. Rotarod tests were performed to determine effects on motor function. After treatment from age 11 to 14 months, brains of 26 mice were collected to quantify aggregated hyperphosphorylated tau by Thioflavin T and immunohistochemistry (IHC) and to quantify total tau (HT7 antibody) and hyperphosphorylated tau (AT8 antibody) in homogenates and a fraction enriched for paired helical filaments. Resveratrol reduced the level of total hyperphosphorylated tau in IHC sections (p=0.036), and morin exhibited a tendency to do so (p=0.29), while the two drugs tended to increase the proportion of solubilizable tau that was hyperphosphorylated, as detected in blots. Neither resveratrol nor morin affected motor function. One explanation of these results is that the drugs might interrupt a late stage in tau aggregation, after small aggregates have formed but before further aggregation has occurred. Further animal studies would be informative to explore the possible efficacy of morin or resveratrol for treating tauopathies.

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