Neuron-Specific Enolase, S-100 Protein, Myelin Basic Protein and Lactate in CSF in Dementia

1997 ◽  
Vol 8 (3) ◽  
pp. 169-173 ◽  
Author(s):  
P.T.G.A. Nooijen ◽  
H.C. Schoonderwaldt ◽  
R.A. Wevers ◽  
O.R. Hommes ◽  
K.J.B. Lamers
Keyword(s):  
Myelin Basic Protein ◽  
Basic Protein ◽  
Neuron Specific Enolase ◽  
S 100

Age-Related Changes of Neuron-Specific Enolase, S-100 Protein, and Myelin Basic Protein Concentrations in Cerebrospinal Fluid

1992 ◽  
Vol 38 (6) ◽  
pp. 813-816 ◽  
Author(s):  
B G van Engelen ◽  
K J Lamers ◽  
F J Gabreels ◽  
R A Wevers ◽  
W J van Geel ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Cell Damage ◽  
Neurological Diseases ◽  
Neuron Specific Enolase ◽  
Quantitative Relation ◽  
Age Related ◽  
S 100 ◽  
Specific Proteins

Abstract Studies on cerebrospinal fluid (CSF) concentrations of neuron-specific enolase (NSE), S-100 protein, and myelin basic protein (MBP) in patients with neurological lesions indicate a quantitative relation between the degree of cell damage in the central nervous system (CNS) and the concentration of these CNS-specific proteins in CSF. Thus NSE, S-100, and MBP could be of use as markers for destructive processes in the CNS. We collected 937 specimens of CSF from children and adults (from newborns to age 91 years) who were undergoing a diagnostic lumbar puncture for several clinical indications. Of these, 79 samples from subjects ranging in age from 0.7 to 66 years could be used retrospectively to construct a reference interval according to our criteria. In these 79 samples no sex dependency existed. The relative increase of NSE, S-100, and MBP with age was similar (1% per year), suggesting a common underlying mechanism. These results emphasize the necessity of using age-matched reference values when the CNS-specific proteins are to be evaluated in neurological diseases. We also present three case histories to discuss the possible clinical relevance of the measurement of NSE, S-100, and MBP in children and adults.

Cerebrospinal neuron-specific enolase, S-100 and myelin basic protein in neurological disorders

2009 ◽  
Vol 92 (3) ◽  
pp. 247-251 ◽  
Author(s):  
K. J. B. Lamers ◽  
B. G. M. Van Engelen ◽  
F. J. M. Gabreëls ◽  
O.R. Hommes ◽  
G. F. Borm ◽  
...  
Keyword(s):  
Myelin Basic Protein ◽  
Neurological Disorders ◽  
Basic Protein ◽  
Neuron Specific Enolase ◽  
S 100

scholarly journals Neuron-Specific Enolase, but Not S100B or Myelin Basic Protein, Increases in Peripheral Blood Corresponding to Lesion Volume after Cortical Impact in Piglets

2012 ◽  
Vol 29 (17) ◽  
pp. 2689-2695 ◽  
Author(s):  
Beth A. Costine ◽  
Patricia B. Quebeda-Clerkin ◽  
Carter P. Dodge ◽  
Brent T. Harris ◽  
Simon C. Hillier ◽  
...  
Keyword(s):  
Myelin Basic Protein ◽  
Peripheral Blood ◽  
Basic Protein ◽  
Neuron Specific Enolase ◽  
Lesion Volume ◽  
Cortical Impact
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