Properties of the Lymphatic Cerebrospinal Fluid Transport System in the Rat: Impact of Elevated Intracranial Pressure

2007 ◽  
Vol 44 (5) ◽  
pp. 423-432 ◽  
Author(s):  
Lena Koh ◽  
Gurjit Nagra ◽  
Miles Johnston
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Transport System ◽  
Fluid Transport ◽  
Elevated Intracranial Pressure

Markedly Elevated Intracranial Pressure Treated With Cranial Vault Expansion, Instead of CSF Shunting, in a Child With Hurler-Scheie Syndrome and Multiple Suture Craniosynostosis

2018 ◽  
Vol 56 (3) ◽  
pp. 395-399
Author(s):  
Jessica A. Ching ◽  
Jared S. Troy ◽  
Ernesto J. Ruas ◽  
Joshua M. Beckman ◽  
Gerald F. Tuite
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Cranial Vault ◽  
Elevated Intracranial Pressure ◽  
Treatment Alternative ◽  
Unique Case ◽  
Shunt Placement ◽  
Scheie Syndrome ◽  
Csf Shunting ◽  
Viable Treatment

Despite a known association of mucopolysaccharidoses (MPS) and craniosynostosis, treatment of elevated intracranial pressure (ICP) in these patients is primarily cerebrospinal fluid (CSF) shunting. We present a unique case of Hurler-Scheie syndrome with multisuture craniosynostosis and elevated ICP, without ventriculomegaly, where elevated ICP was successfully treated with extensive cranial vault expansion and shunt placement was avoided. Patients with MPS should be evaluated for craniosynostosis, and calvarial vault expansion may be considered as a viable treatment alternative to CSF shunting for elevated ICP in select patients.

Intervention for elevated intracranial pressure improves success rate after repair of spontaneous cerebrospinal fluid leaks

2017 ◽  
Vol 127 (9) ◽  
pp. 2011-2016 ◽  
Author(s):  
William Teachey ◽  
Jessica Grayson ◽  
Do-Yeon Cho ◽  
Kristen O. Riley ◽  
Bradford A. Woodworth
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Success Rate ◽  
Elevated Intracranial Pressure ◽  
Cerebrospinal Fluid Leaks

In reference to intervention for elevated intracranial pressure improves success rate after repair of spontaneous cerebrospinal fluid leaks

2017 ◽  
Vol 128 (8) ◽  
pp. E271-E271 ◽  
Author(s):  
João Mangussi‐Gomes ◽  
Leonardo L. Balsalobre ◽  
Marcos Q. T. Gomes ◽  
Eduardo A. S. Vellutini ◽  
Aldo E. C. Stamm ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Success Rate ◽  
Elevated Intracranial Pressure ◽  
Cerebrospinal Fluid Leaks

scholarly journals Uptake of the antisecretory factor peptide AF-16 in rat blood and cerebrospinal fluid and effects on elevated intracranial pressure

2014 ◽  
Vol 157 (1) ◽  
pp. 129-137 ◽  
Author(s):  
Mohamed Al-Olama ◽  
Stefan Lange ◽  
Ivar Lönnroth ◽  
Kliment Gatzinsky ◽  
Eva Jennische
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Elevated Intracranial Pressure ◽  
Rat Blood ◽  
Antisecretory Factor

Management of spontaneous cerebrospinal fluid leaks of the sphenoid sinus: our experience

2014 ◽  
Vol 128 (9) ◽  
pp. 797-802 ◽  
Author(s):  
G Fyrmpas ◽  
I Konstantinidis ◽  
P Selviaridis ◽  
J Constantinidis
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Sphenoid Sinus ◽  
Successful Outcome ◽  
Dietary Advice ◽  
Elevated Intracranial Pressure ◽  
Endoscopic Closure ◽  
Cerebrospinal Fluid Leaks ◽  
Stable Reconstruction

AbstractBackground:Closure of spontaneous sphenoid sinus cerebrospinal fluid leaks can be challenging because of the relative inaccessibility of the lateral recess and the presence of intracranial hypertension. We present our experience of such cases and highlight factors associated with a successful outcome.Methods:Eleven patients with spontaneous, laboratory confirmed, sphenoid sinus cerebrospinal fluid leaks were included. All patients underwent endoscopic closure by either a three-layer technique or fat obliteration.Results:In all but one patient, the leak was successfully sealed (success rate, 90.9 per cent; mean follow up, 37.1 months). Elevated intracranial pressure was measured in eight patients, two of whom did not exhibit relevant clinical or radiological characteristics. Five patients received diuretics and dietary advice for weight reduction. In one patient with recurrence two weeks after repair, successful revision was performed by additional placement of a ventriculoperitoneal shunt (follow up, 67 months).Conclusion:Long-lasting cerebrospinal fluid fistula sealing in the sphenoid sinus requires stable reconstruction of the defect in three layers or fat obliteration if the anatomy is unfavourable. All patients should be intra- and post-operatively screened for elevated intracranial pressure to identify those who need additional intracranial pressure reduction measures.

scholarly journals Low meningitis-incidence in primary spontaneous compared to secondary cerebrospinal fluid rhinorrhoea

2012 ◽  
Vol 50 (1) ◽  
pp. 73-79
Author(s):  
Sophia C. Poletti-Muringaseril ◽  
Kaspar Rufibach ◽  
Christian Ruef ◽  
David Holzmann ◽  
Michael B. Soyka
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Lower Incidence ◽  
Tertiary Care ◽  
Csf Leak ◽  
Clinical Impression ◽  
Pathophysiological Mechanism ◽  
Elevated Intracranial Pressure ◽  
Tertiary Care Medical Center ◽  
Csf Rhinorrhoea

Objective: Spontaneous cerebrospinal fluid (CSF) rhinorrhoea is a separate clinical entity with elevated intracranial pressure as its most probable pathophysiological mechanism. Having the clinical impression of distinct courses of diseases in primary spontaneous (PS) compared to secondary CSF rhinorrhoea, our objective was to identify whether the two forms differ in the duration of CSF rhinorrhoea and the incidence of meningitis. Methods: Chart review performed on all patients referred with a CSF leak to our tertiary-care medical center over a 20-year period from 1990 to 2010. Results: In total, 58 cases suffering from CSF rhinorrhoea could be included. The aetiology was primary spontaneous in 23 (40%) and secondary in 35 (60%) patients. The duration of CSF rhinorrhoea was notably longer in patients with PS CSF rhinorrhoea. Moreover, we could show a significantly lower incidence of meningitis with PS CSF rhinorrhoea compared to the secondary group (annual incidence of 0.12 vs. 1.22 episodes). Conclusion: A significantly lower incidence and delayed onset of meningitis in patients suffering from PS CSF rhinorrhoea could be explained by an elevated intracranial pressure that hinders the ascension of bacteria. The closure of a leak in secondary CSF fistula seems more urgent than in PS CSF fistulas.

In response to in reference to intervention for elevated intracranial pressure improves success rate after repair of spontaneous cerebrospinal fluid leaks

2018 ◽  
Vol 128 (8) ◽  
pp. E272-E272 ◽  
Author(s):  
William Teachey ◽  
Jessica Grayson ◽  
Do‐Yeon Cho ◽  
Bradford A. Woodworth ◽  
Kristen O. Riley
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Success Rate ◽  
Elevated Intracranial Pressure ◽  
Cerebrospinal Fluid Leaks
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