The Use of MDCT-Based Computer-Aided Pathway Finding for Mediastinal and Perihilar Lymph Node Biopsy: A Randomized Controlled Prospective Trial

Respiration ◽  
2007 ◽  
Vol 74 (4) ◽  
pp. 423-431 ◽  
Author(s):  
Geoffrey McLennan ◽  
J. Scott Ferguson ◽  
Karl Thomas ◽  
Angela S. Delsing ◽  
Janice Cook-Granroth ◽  
...  
Keyword(s):  
Lymph Node ◽  
Prospective Trial ◽  
Lymph Node Biopsy ◽  
Randomized Controlled ◽  
Node Biopsy ◽  
Computer Aided

scholarly journals AXILLARY LYMPH NODE DISSECTION IN BREAST CANCER PATIENTS. THE ROLE OF SENTINEL LYMPH NODE BIOPSY

2015 ◽  
Vol 62 (4) ◽  
pp. 351-356
Author(s):  
Nicolae Bacalbasa ◽  
◽  
Olivia Ionescu ◽  
Irina Balescu ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Early Breast Cancer ◽  
Lymph Node Biopsy ◽  
Controlled Trials ◽  
Axillary Lymph ◽  
Randomized Controlled ◽  
Node Biopsy

Rationale. Since its introduction in the early 1990s, sentinel lymph node biopsy (SLNB) is regarded as the standard treatment for patients with clinically negative axillary lymph nodes (LNs) on initial presentation. Classically, when the SLN biopsy is negative, the axillary LN dissection (ALND) is no further necessary. On the other hand, performing complete ALND in case of a positive SLNB is controversial, recent data from randomized controlled studies suggesting that, in these cases, the tumor biology has a greater impact on the adjuvant treatment decision than the completion of an ALND. Objective. The aim of this review is to ascertain whether axillary LN surgery has survival benefits in women with early breast cancer and SLN involvement, either micro-metastatic or macro-metastatic. Moreover, it tries to assess the value of SLN biopsy before and after primary systemic chemotherapy and its role in the staging of the axilla in locally recurrent breast cancer. Materials and method. We searched Pubmed, Medline, the Cochrane Register of Controlled Trials and G.I.N (Guidelines International Network) databases for English language articles about the need of ALND in women with both positive and negative SLNs using controlled vocabulary (e.g. “breast cancer”) and key words (e.g “sentinel lymph node”, “axilla dissection”). The analysis was restricted to retrospective studies and randomized controlled trials focusing on survival benefits in terms overall (OS) or disease-free survival (DFS). Conclusions. There is increasing evidence which indicates that ALND can be avoided in a specific group of patients with early breast cancer, even though the SLNB is positive. A correlation between the clinico-pathological features of the breast cancer and the probability of residual disease in the axilla, could allow the selection of cases in which ALND can be omitted. In the context of neo-adjuvant chemotherapy, it is not yet established if positive SLNs could be converted to negative SLNs after chemotherapy as the rate of false-negative results is still high.

Morbidity After Sentinel Lymph Node Biopsy in Primary Breast Cancer: Results From a Randomized Controlled Trial

2005 ◽  
Vol 23 (19) ◽  
pp. 4312-4321 ◽  
Author(s):  
Anand David Purushotham ◽  
Sara Upponi ◽  
Manfred Borislav Klevesath ◽  
Lynda Bobrow ◽  
Keith Millar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Randomized Controlled Trial ◽  
Lymph Node ◽  
Controlled Trial ◽  
Lymph Node Biopsy ◽  
Psychological Morbidity ◽  
Study Group ◽  
Node Negative ◽  
Randomized Controlled ◽  
Node Biopsy

Purpose Axillary lymph node dissection (ALND) as part of surgical treatment for patients with breast cancer is associated with significant morbidity. Sentinel lymph node biopsy (SLNB) is a newly developed method of staging the axilla and has the potential to avoid an ALND in lymph node–negative patients, thereby minimizing morbidity. The aim of this study was to investigate physical and psychological morbidity after SLNB in the treatment of early breast cancer in a randomized controlled trial. Patients and Methods Between November 1999 and February 2003, 298 patients with early breast cancer (tumors 3 cm or less on ultrasound examination) who were clinically node negative were randomly allocated to undergo ALND (control group) or SLNB followed by ALND if subsequently found to be lymph node positive (study group). A detailed assessment of physical and psychological morbidity was performed during a 1-year period postoperatively. Results A significant reduction in postoperative arm swelling, rate of seroma formation, numbness, loss of sensitivity to light touch and pinprick was observed in the study group. Although shoulder mobility was less impaired on average in the study group, this was significant only for abduction at 1 month and flexion at 3 months. Scores reflecting quality of life and psychological morbidity were significantly better in the study group in the immediate postoperative period, with fewer long-term differences. Conclusion SLNB in patients undergoing surgery for breast cancer results in a significant reduction in physical and psychological morbidity.

Sentinel lymph node biopsy vs no axillary surgery in early breast cancer clinically and ultrasonographically node negative: A prospective randomized controlled trial—VENUS trial

2020 ◽  
Vol 26 (10) ◽  
pp. 2087-2089
Author(s):  
Danielle Cristina Miyamoto Araújo ◽  
Giuliano Mendes Duarte ◽  
Rodrigo Menezes Jales ◽  
Julia Yoriko Shinzato ◽  
Cassio Cardoso Filho ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Randomized Controlled Trial ◽  
Lymph Node ◽  
Controlled Trial ◽  
Lymph Node Biopsy ◽  
Node Negative ◽  
Axillary Surgery ◽  
Randomized Controlled ◽  
Node Biopsy ◽  
Prospective Randomized Controlled Trial
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