Improving Culture Conditions for Temporomandibular Joint Disc Tissue Engineering

2007 ◽  
Vol 185 (4) ◽  
pp. 246-257 ◽  
Author(s):  
D.E. Johns ◽  
K.A. Athanasiou
Keyword(s):  
Tissue Engineering ◽  
Temporomandibular Joint ◽  
Culture Conditions ◽  
Temporomandibular Joint Disc ◽  
Disc Tissue

scholarly journals Tissue engineering toward temporomandibular joint disc regeneration

2018 ◽  
Vol 10 (446) ◽  
pp. eaaq1802 ◽  
Author(s):  
Natalia Vapniarsky ◽  
Le W. Huwe ◽  
Boaz Arzi ◽  
Meghan K. Houghton ◽  
Mark E. Wong ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Temporomandibular Joint ◽  
Treated Group ◽  
Defect Closure ◽  
Repair Tissue ◽  
Temporomandibular Joint Disc ◽  
Disc Regeneration ◽  
Tmj Disc ◽  
Engineering Strategy

Treatments for temporomandibular joint (TMJ) disc thinning and perforation, conditions prevalent in TMJ pathologies, are palliative but not reparative. To address this, scaffold-free tissue-engineered implants were created using allogeneic, passaged costal chondrocytes. A combination of compressive and bioactive stimulation regimens produced implants with mechanical properties akin to those of the native disc. Efficacy in repairing disc thinning was examined in minipigs. Compared to empty controls, treatment with tissue-engineered implants restored disc integrity by inducing 4.4 times more complete defect closure, formed 3.4-fold stiffer repair tissue, and promoted 3.2-fold stiffer intralaminar fusion. The osteoarthritis score (indicative of degenerative changes) of the untreated group was 3.0-fold of the implant-treated group. This tissue engineering strategy paves the way for developing tissue-engineered implants as clinical treatments for TMJ disc thinning.

scholarly journals Remaining Hurdles for Tissue-Engineering the Temporomandibular Joint Disc

2019 ◽  
Vol 25 (3) ◽  
pp. 241-256 ◽  
Author(s):  
Ryan P. Donahue ◽  
Jerry C. Hu ◽  
Kyriacos A. Athanasiou
Keyword(s):  
Tissue Engineering ◽  
Temporomandibular Joint ◽  
Temporomandibular Joint Disc

scholarly journals Biological Treatments for Temporomandibular Joint Disc Disorders: Strategies in Tissue Engineering

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 933
Author(s):  
Daniela Trindade ◽  
Rachel Cordeiro ◽  
Henrique Cardoso José ◽  
David Faustino Ângelo ◽  
Nuno Alves ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Temporomandibular Joint ◽  
Total Disc Replacement ◽  
Special Focus ◽  
Temporomandibular Joint Disc ◽  
Complete Knowledge ◽  
Masticatory System ◽  
Materials Used ◽  
Important Structure

The temporomandibular joint (TMJ) is an important structure for the masticatory system and the pathologies associated with it affect a large part of the population and impair people’s lifestyle. It comprises an articular disc, that presents low regeneration capacities and the existing clinical options for repairing it are not effective. This way, it is imperative to achieve a permanent solution to guarantee a good quality of life for people who suffer from these pathologies. Complete knowledge of the unique characteristics of the disc will make it easier to achieve a successful tissue engineering (TE) construct. Thus, the search for an effective, safe and lasting solution has already started, including materials that replace the disc, is currently growing. The search for a solution based on TE approaches, which involve regenerating the disc. The present work revises the TMJ disc characteristics and its associated diseases. The different materials used for a total disc replacement are presented, highlighting the TE area. A special focus on future trends in the field and part of the solution for the TMJ problems described in this review will involve the development of a promising engineered disc approach through the use of decellularized extracellular matrices.

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