Corticosteroids and Ciclosporin A in Idiopathic Membranous Nephropathy: Higher Remission Rates of Nephrotic Syndrome and Less Adverse Reactions than after Traditional Treatment with Cytotoxic Drugs

2007 ◽  
Vol 27 (3) ◽  
pp. 226-231 ◽  
Author(s):  
Dimitrios S. Goumenos ◽  
Konstantinos P. Katopodis ◽  
Ploumis Passadakis ◽  
Eleftheria Vardaki ◽  
Vasilios Liakopoulos ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Membranous Nephropathy ◽  
Adverse Reactions ◽  
Cytotoxic Drugs ◽  
Idiopathic Membranous Nephropathy ◽  
Traditional Treatment ◽  
Ciclosporin A ◽  
Remission Rates

Effect of Prolonged Tacrolimus Treatment in Idiopathic Membranous Nephropathy with Nephrotic Syndrome

Pharmacology ◽  
2013 ◽  
Vol 91 (5-6) ◽  
pp. 259-266 ◽  
Author(s):  
Hang Yuan ◽  
Nian Liu ◽  
Guang-Dong Sun ◽  
Ye Jia ◽  
Ping Luo ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Membranous Nephropathy ◽  
Idiopathic Membranous Nephropathy

Dysbiosis of gut microbiota in adult idiopathic membranous nephropathy with nephrotic syndrome

2020 ◽  
Vol 147 ◽  
pp. 104359 ◽  
Author(s):  
Jun Zhang ◽  
Dan Luo ◽  
Zhiming Lin ◽  
Wenying Zhou ◽  
Jialing Rao ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Gut Microbiota ◽  
Membranous Nephropathy ◽  
Idiopathic Membranous Nephropathy

scholarly journals Clinical observation and analysis of patients with idiopathic membranous nephropathy combined with low 25(OH)D3 levels

2020 ◽  
Author(s):  
Fan Zou ◽  
Yu Huang ◽  
Zhenhua Yang
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Albumin ◽  
Serum Calcium ◽  
Membranous Nephropathy ◽  
Serum Phosphorus ◽  
Idiopathic Membranous Nephropathy ◽  
Clinical Indicators ◽  
Hs Crp ◽  
Phosphorus Levels

Abstract Background: To investigate correlations between 25-hydroxyvitamin D3 [25(OH)D3] levels and selected clinical indicators and renal pathology at initial onset of idiopathic membranous nephropathy (IMN) and to analyse changes in the main quantifiable indicators in IMN patients with different 25(OH)D3 levels.Methods: A total of 109 patients admitted to the Department of Nephrology of the First Affiliated Hospital of Guangxi Medical University between August 2015 and April 2019 and diagnosed with IMN were reviewed. Comparative analysis of the effects of different 25(OH)D3 levels on clinical and pathological indicators of IMN was performed, and changes in serum albumin, the estimated glomerular filtration rate (eGFR), serum creatinine and other clinical indicators in these patients during the follow-up were analysed.Results: The 109 patients with IMN had 25(OH)D3 deficiency [25(OH)D3<70 nmol/L]. The incidence of nephrotic syndrome, serum phosphorus levels, high-sensitivity C-reactive protein (hs-CRP) levels, and erythrocyte sedimentation rates (ESRs) were higher in the 25(OH)D3<25 nmol/L group than in the 25(OH)D3≥25 nmol/L group. In contrast, total protein (TP), albumin (ALB), serum calcium, and IgG levels were lower in the 25(OH)D3<25 nmol/L group (P<0.05). No pathological parameters differed significantly between the two groups (P>0.05). Bivariate correlation analysis showed that 25(OH)D3 was positively correlated with nephrotic syndrome, TP levels, ALB levels, the eGFR, serum calcium levels and IgG levels (P<0.05) and negatively correlated with age, blood pressure, Scr levels, 24-hour urinary protein (UP) quantitation, serum phosphorus levels, hs-CRP levels and the ESR (P<0.05). In single-factor repeated measures analysis of variance, the ALB levels in the 25(OH)D3<25 nmol/L and 25(OH)D3≥25 nmol/L groups showed an increasing trend but were lower in the 25(OH)D3<25 nmol/L group than in the 25(OH)D3≥25 nmol/L group at each follow-up time point (P<0.001).Conclusion: Reduced 25(OH)D3 levels are prevalent among IMN patients. During the follow-up, serum albumin increased significantly in patients receiving vitamin D supplementation. 25(OH)D3 may play an important role in IMN development.

Sign in / Sign up

Export Citation Format

Share Document