Regional Cerebral Perfusion Differences between Periventricular Grey, Thalamic and Dual Target Deep Brain Stimulation for Chronic Neuropathic Pain

2007 ◽  
Vol 85 (4) ◽  
pp. 175-183 ◽  
Author(s):  
Erlick A.C. Pereira ◽  
Alexander L. Green ◽  
Kevin M. Bradley ◽  
Nigel Soper ◽  
Liz Moir ◽  
...  
2015 ◽  
Vol 38 (6) ◽  
pp. E11 ◽  
Author(s):  
Jennifer F. Russo ◽  
Sameer A. Sheth

Chronic neuropathic pain is estimated to affect 3%-4.5% of the worldwide population. It is associated with significant loss of productive time, withdrawal from the workforce, development of mood disorders such as depression and anxiety, and disruption of family and social life. Current medical therapeutics often fail to adequately treat chronic neuropathic pain. Deep brain stimulation (DBS) targeting subcortical structures such as the periaqueductal gray, the ventral posterior lateral and medial thalamic nuclei, and the internal capsule has been investigated for the relief of refractory neuropathic pain over the past 3 decades. Recent work has identified the dorsal anterior cingulate cortex (dACC) as a new potential neuromodulation target given its central role in cognitive and affective processing. In this review, the authors briefly discuss the history of DBS for chronic neuropathic pain in the United States and present evidence supporting dACC DBS for this indication. They review existent literature on dACC DBS and summarize important findings from imaging and neurophysiological studies supporting a central role for the dACC in the processing of chronic neuropathic pain. The available neurophysiological and empirical clinical evidence suggests that dACC DBS is a viable therapeutic option for the treatment of chronic neuropathic pain and warrants further investigation.


Pain ◽  
2006 ◽  
Vol 125 (1) ◽  
pp. 188-196 ◽  
Author(s):  
Clement Hamani ◽  
Jason M. Schwalb ◽  
Ali R. Rezai ◽  
Jonathan O. Dostrovsky ◽  
Karen D. Davis ◽  
...  

2015 ◽  
Vol 8 (2) ◽  
pp. 420
Author(s):  
A. Gisik ◽  
H. Brown ◽  
R. Boyle ◽  
S. Olson ◽  
B. Hall

2014 ◽  
Vol 15 (3) ◽  
pp. 283-292 ◽  
Author(s):  
Alan M. Gray ◽  
Elizabeth Pounds-Cornish ◽  
Fiona J.R. Eccles ◽  
Tipu Z. Aziz ◽  
Alexander L. Green ◽  
...  

2009 ◽  
Vol 13 (S1) ◽  
Author(s):  
M. Carneiro ◽  
M. Sousa ◽  
Ví. Rebelo ◽  
R. Vaz

2017 ◽  
Vol 20 (5) ◽  
pp. 504-513 ◽  
Author(s):  
Vasco Abreu ◽  
Rui Vaz ◽  
Virgínia Rebelo ◽  
Maria José Rosas ◽  
Clara Chamadoira ◽  
...  

2000 ◽  
Vol 5 (1) ◽  
pp. 101-106
Author(s):  
Jung Y Park ◽  
Andres M Lozano

Neurosurgery can play a role in the management of patients with refractory chronic neuropathic pain. However, selecting patients as candidates for surgery and choosing the most appropriate surgical procedure is challenging, and surgical interventions often have limited efficacy. When considering surgery, neuroaugmentative or neuromodulative procedures (eg, peripheral, spinal, motor cortex or deep brain stimulation) are generally preferred over ablative procedures as initial modalities. With better understanding of specific pain mechanisms, surgery will have more to offer patients with chronic neuropathic pain.


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